I will examine by observing and looking around! Discovery, visualization, diagnosis, treatment.
Life (Saitama University Research Seed Collection 2025-25 p.128)
Keywords: biosensor, live imaging, drug delivery, nanocapsule, theranostics, luminescence
We aim to non-invasively visualize the functions and dysfunctions of biological entities for disease diagnosis, toxicity testing, and active ingredient screening. Utilizing live cell imaging and flow cytometry for high-speed analysis, we are developing an analytical system comparable to animal experiments. We create non-invasive sensor molecules that detect chemical reactions and physical interactions occurring in vivo, introduce them into cells, expose them to harmful or effective substances, and detect the sensor's response using light (fluorescence). We are establishing testing methods for the toxicity of anticancer drugs, air pollutants, and the efficacy of quasi-drugs. On the other hand, we are also advancing the production of nanocapsules composed of disease-targeting sensor molecules. All production is conducted under physiological conditions, aiming for a cocktail delivery system that combines conventional synthetic pharmaceuticals and biopharmaceuticals. The sensor molecules are used to monitor the delivery situation. Furthermore, we are also working on constructing an external discharge system for harmful substances accumulated in the body due to metabolic disorders and a discharge system.
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Miho Suzuki, Associate Professor Graduate School of Science and Technology, Department of Materials Science, Field of Material Functions [Recent Research Themes] ● Development of a macrophage polarization detection system ● Development of a chemical reaction visualization system in microchannels
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【Appeal Points to the Industry】 ● Highly compatible sensor molecules can monitor multiple in vivo reactions simultaneously. ● Sensor molecules with excellent quantitativeness enable standardization and statistical analysis of evaluations. ● Simple-structured sensor molecules and nanocapsules allow for easy modification of production and target detection. ● Drug cocktail delivery systems are rare. ● Cost reduction through the use of fluorescent proteins produced by microorganisms. 【Examples of Practical Use, Applications, and Utilization】 ● Animal experiment alternative system for testing the efficacy of anticancer drugs. ● Animal experiment alternative system for verifying the effects of quasi-drugs. ● Harmful substance discharge system. ● Simultaneous pathological diagnosis chip for multiple items. ● Synthetic pharmaceuticals and biopharmaceuticals cocktail delivery system.
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Optical properties of nanocapsules
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The Saitama University Open Innovation Center is a center that functions as a liaison office for industry-academia-government collaboration. It consists of three departments: the Industry-Academia-Government Collaboration Department, the Intellectual Property Department, and the Startup Support Department, each staffed with coordinators well-versed in various fields. The center's activities include solving technical challenges in companies, supporting the implementation of joint research, and conducting technology transfer aimed at introducing and utilizing Saitama University's intellectual property.