Unlocking the future with mysterious sugar chains!
Life (Saitama University Research Seed Collection 2025-25 p.130)
Keywords: complex carbohydrates, glycan, organic synthesis, bioorganic chemistry, fluorescence, polymer science, bioactive substances, structure-activity relationship, next-generation antibodies.
The structure formed by sugars like glucose linked together in a chain is called a glycan, and a glycan made up of a few sugars is referred to as an oligosaccharide. The structure of these glycans determines blood types such as type A and type B! Additionally, glycans are involved in infections caused by viruses like influenza. Various glycans are actively functioning in our daily lives. Although there is no medical department, we conduct research and development in drug discovery related to detection, diagnosis, and treatment from an engineering and science perspective. When considering each cell in our body as a giant molecule, it appears that many functional substances (glycans and proteins) are presented on its surface. Therefore, we have discovered that by artificially gathering functional substances to create multivalent (cluster-type) compounds, we can produce substances with enhanced activity. Currently, we are conducting research and development aimed at creating functional substances and inducing multivalent compounds, leading to new drug discovery.
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Koji Matsuoka, Professor Graduate School of Science and Technology, Department of Materials Science, Materials Function Area 【Recent Research Themes】 ● Development of detection and diagnostic drugs using next-generation antibodies ● Development of high-performance materials induced to a multivalent (cluster) type of glycan ● Development of new luminescent materials utilizing fluorescence ● Development of cluster-type bioprobes using bioactive substances ● Synthesis research of liquid crystal glycan derivatives
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【Appeal Points to the Industry】 ● Pioneering the creation of cluster-type toxin neutralizers worldwide! ● First in the world to synthesize a polymer-type substrate utilizing two types of fluorescence! ※ Precision organic synthesis allows for the induction of various target cluster-type compounds, with expected sensitivity improvements of hundreds to thousands of times. ● Numerous patents have been filed!!! 【Examples of Practical Application, Use Cases, and Utilization】 ● Development of technology utilizing sialic acid derivatives. (Tetrahedron Lett. 2024) ● Construction of a protein evaluation system using fluorescent polymer substrates. (Biomacromolecules 2024) ● Development of recycling separation methods in liquid chromatography (Patent No. 7408230) ● Utilization of peptides for cancer diagnosis (Patent No. 6653504) ● Development of new cancer detection and treatment drugs using light. (ACS Omega 2023)
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The Saitama University Open Innovation Center is a center that functions as a liaison office for industry-academia-government collaboration. It consists of three departments: the Industry-Academia-Government Collaboration Department, the Intellectual Property Department, and the Startup Support Department, each staffed with coordinators well-versed in various fields. The center's activities include solving technical challenges in companies, supporting the implementation of joint research, and conducting technology transfer aimed at introducing and utilizing Saitama University's intellectual property.
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