Enhancing molecular bonds to protect health!
Life (Saitama University Research Seed Collection 2025-25 p.132)
Keywords: glycan, antibody, molecular recognition, multivalent effect, detection reagent
The proverb "When three people gather, the wisdom of Monju" is often heard in our daily lives. Did you know that the power of groups exists even at the molecular level? Glycans facilitate intercellular communication by binding to glycan receptors, but individual glycans have only weak binding strength. However, when multiple glycans come together, their effect far exceeds simple addition, sometimes exhibiting astonishing powers that can be hundreds to hundreds of thousands of times greater. This is called the "multivalency effect." The characteristic of our research is to artificially replicate and further enhance this clever mechanism found in nature. We design artificial molecules that accumulate various molecules, such as glycans and next-generation antibodies, and investigate their interactions in detail. By effectively utilizing the power of molecular cooperation, we hope to contribute to the future of medicine.
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Takahiko Matsushita, Assistant Professor Graduate School of Science and Engineering, Department of Material Science, Material Function Area 【Recent Research Topics】 ● Prodrug development of anti-influenza virus drugs ● Development of bispecific antibodies and phototherapy drugs using next-generation antibodies ● Research on lipid membrane adhesion molecules
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【Appeal Points to the Industry】 ● We have a platform for multivalency of biomolecules. ● We have a track record of patent applications. 【Examples of Practical Applications, Use Cases, and Utilization】 ● Enhanced interaction with glycan recognition proteins through multivalency of glycan molecules. ● Increased sensitivity of enzyme immunoassays through multivalency of next-generation antibodies.
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Antigen recognition of multivalent VHH antibodies.
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The Saitama University Open Innovation Center is a center that functions as a liaison office for industry-academia-government collaboration. It consists of three departments: the Industry-Academia-Government Collaboration Department, the Intellectual Property Department, and the Startup Support Department, each staffed with coordinators well-versed in various fields. The center's activities include solving technical challenges in companies, supporting the implementation of joint research, and conducting technology transfer aimed at introducing and utilizing Saitama University's intellectual property.