Next-generation gene cell therapy purification technology Nanofiber AstreAdept
Astrea Bioseparations
Next-generation purification nanofibers optimal for the purification of plasmid and viral particles.
In the world of bioprocessing, traditional porous methods used for antibody purification have been mainstream for decades, but they are unsuitable for the purification of large molecules such as lentiviruses, plasmids, and exosomes used in gene cell therapy, making purification difficult. Astrea Bioseparations has developed a next-generation bioprocessing device utilizing cutting-edge nanofiber technology called "AstreAdept." The upcoming nanofibers will be created by electrospinning a blend of two types of polymers, combining cellulose-based and non-cellulose-based materials. Due to their nanoscale size, they have a high surface area-to-volume ratio, making them very attractive. AstreAdept achieves the following: Efficiency: AstreAdept compresses processes, reducing time and costs. Innovative technology: It utilizes nanofibers and convection to enable fast and highly efficient washing. Wide applicability: A scalable solution that can accommodate everything from research to manufacturing. Optimization of exosome purification, bacteriophage, plasmid purification, and the purification of single-stranded pDNA and mRNA before and after IVT.
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basic information
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Applications/Examples of results
pDNAHERO Plasmid purification/polishing Single-stranded plasmid purification Removal of dsRNA LentiHERO Purification of lentivirus, retrovirus, bacteriophage, etc. ExoHERO Exosome purification
Detailed information
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This shows how the composite nanofiber structure is created. Figure 1 illustrates how this composite nanofiber structure is made. Two types of polymer solutions are supplied through a metal needle under applied voltage.
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The scanning electron microscope (SEM) images of the composite nanofiber membrane show a high surface area to volume ratio and improved permeability of the nanofibers. These characteristics result in an increased accessible bonding surface area and a high flow rate.
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Company information
Biotage Japan Co., Ltd. is a wholly-owned subsidiary of Biotage AB, which is headquartered in Uppsala, Sweden (BIOT: NASDAQ/OMX Stockholm). Biotage AB has its roots in several venture companies that originated from Uppsala University, a leading science and engineering university in the Nordic region. After undergoing international acquisitions and restructuring throughout the 2000s, it has recently achieved remarkable growth as a global company.