Measurement of nitrite in hypromellose [Ion Chromatography Technical Document]
Ion chromatography
Measurement of nitrite in hydroxypropyl methylcellulose by ion chromatography.
The presence of carcinogenic nitrosamines in pharmaceuticals poses a threat to patient safety. By controlling the concentration of nitrites in drugs and processes, the formation of nitrosamines can be prevented, making it essential to have a highly sensitive method for analyzing nitrites in pharmaceuticals and their raw materials. In many cases, dimethylamine is used in the synthesis of various drugs. Under acidic conditions, it reacts with nitrites to form nitrosamines. This also applies to the production of hydroxypropyl methylcellulose (HPMC), a common excipient. This technical document introduces the quantification of nitrites in hydroxypropyl methylcellulose using ion chromatography (IC) with direct UV/VIS detection.
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This describes the quantification of nitrites in hydroxypropyl methylcellulose using ion chromatography (IC) with Metrosep A Supp 10 columns and direct UV/VIS detection at 215 nm. The sample pretreatment employs the Metrohm Intelligent Pre-Concentration Technique with Matrix Elimination (MiPCT-ME).
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Metrom AG, based in Herisau, Switzerland, is a leading company specializing in ion analysis with over 70 years of history. It provides products and services in more than 140 countries worldwide. Based on Swiss technology developed over many years, the equipment comes with a 3-year warranty.
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