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Freeze-drying technology, which has many advantages such as long-term preservation, is becoming increasingly important in the manufacturing of pharmaceuticals and food products. Freeze-drying requires expensive equipment and long processing times, so to improve the efficiency of the freeze-drying process, it is considered effective to raise the temperature of the frozen product to shorten the sublimation time. However, exceeding the critical temperature can lead to the collapse of the physical structure, resulting in incomplete drying and degradation of the product, such as a decrease in solubility. Therefore, it is necessary to determine the collapse temperature (Tc) and eutectic melting temperature (Teu) to establish the maximum allowable product temperature (critical temperature). The freeze-drying microscopy system is a device that can quickly determine the collapse temperature (Tc) and eutectic melting temperature (Teu) using small samples.

• Analytical Equipment and Devices
• Other microscopes
• Other physicochemical equipment

When evaluating the moisture adsorption process of a substance, the relationship between the equilibrium moisture content of the substance and relative humidity, represented by the water vapor adsorption isotherm, is important, and it is necessary to measure this. The Japanese Pharmacopoeia also describes the adsorption-desorption isotherm measurement method. The water vapor adsorption measurement device of the E series automatically sets relative humidity and temperature, measuring the weight change due to the sample's water vapor adsorption and desorption with extremely high precision, automating the adsorption isotherm measurement. At the same time, it can record changes in the appearance characteristics of the sample using the built-in camera that is standard equipment. Additionally, by connecting FTIR or RAMAN probes, it is also possible to analyze the water vapor adsorption and desorption characteristics simultaneously with weight changes and spectral analysis.

• Analytical Equipment and Devices
• Other powder equipment
• Temperature and humidity measuring instruments

The diversifying powder technology, particularly solid pharmaceutical raw materials, is pressing the need for a wide range of high-precision chemical property measurement techniques regarding components and structures. The IGC inverse gas chromatography has been developed as a surface property measurement technique using gas for the study of surface properties of fine particles, thin films, and fiber materials. SEA measures the physicochemical properties of pharmaceutical materials, specifically the surface free energy of powders and acidic/basic parameters, which are crucial factors affecting many substances' products and manufacturing processes, with high sensitivity that was previously impossible with conventional methods. SEA has been developed as a practical device through collaborative research with pharmaceutical research institutions and companies, based on techniques that some researchers have traditionally spent time and effort on, and it performs sample measurements in a set humidity environment completely automatically from sample injection to data processing.

• Other measurement, recording and measuring instruments

Observation and measurement using microscopes are essential in a wide range of fields such as pharmaceuticals, food, chemistry, and industry. Although micro-samples placed on a microscope stage are significantly affected by environmental factors such as temperature and humidity, it was not possible to control the relative humidity under constant conditions for observation. The humidity control microscope stage is a new microscope stage that solves this problem. It reproduces the humidity environment within the microscopic sample stage under set conditions, enabling continuous observation and measurement of changes in sample properties. Additionally, by connecting with FT-IR and Raman spectroscopic measurement devices, it opens up new fields of spectroscopic measurement. The temperature and humidity control RH generator achieves precise temperature and humidity control through the mixing of nitrogen gas and saturated water vapor.

• Other microscopes

It is a cylindrical cup made from a special stainless steel alloy with excellent chemical resistance, which is an essential auxiliary material for creating barrier circles.

• Analytical Equipment and Devices