ハイペップ研究所 List of Products and Services

AGP and related compounds = Applications in regenerative medicine and biomaterials Elucidation of angiogenesis mechanisms → Understanding of cancer proliferation and metastasis → Inhibition and antagonists

• Pharmaceutical Intermediates
• Human cells
• Peptide synthesis

We have developed a polyamide that specifically stains the telomeres of chromosomes, and it has now been commercialized as a kit. The repetitive region of simple base sequences located at the ends of chromosomes is referred to as telomeres, which in vertebrates consists of the repeat sequence (TTAGGG). It has been hypothesized that the length of telomeres is related to cancer and aging (progeria) in individuals, increasing their importance as targets for molecular imaging. A method for detecting telomere DNA on chromosomes using fluorescently labeled peptide nucleic acid (PNA) probes with fluorescence in situ hybridization (FISH) is known; however, PNA is difficult to transfer into cells. A tandem polyamide that specifically binds to the repeat sequence (TTAGGG) of vertebrate telomeres has been reported (2001). By using the fluorescently labeled HPTH59, it is possible to fluorescently stain telomere DNA much more simply and quickly than with PNA FISH or Southern blotting techniques.

• DNA labeling kit
• Staining Reagents

Experienced peptide science professionals will reliably synthesize peptides with pyrrole and imidazole frameworks (PIPA) that have been amino acid-derivatized, utilizing their unique know-how and technology. We have also developed HPLC columns for the analysis and purification of these compounds.

• Other Nucleic Acid/DNA Research

The protein detection system "PepTenChip" is a next-generation biochip that arrays labeled peptides as capture molecules. By building a database, it enables the identification of proteins using the protein fingerprinting method. It also supports tailor-made manufacturing according to the sample. Custom sizes other than slide glass are available. 【Features】 - High mechanical strength - Chemically stable - No autofluorescence - Excellent processability (easy to form microchannels) - Easy to regenerate and reuse For more details, please contact us or download the catalog.

• Microarrays and DNA chips

The Enantiomer Labeling Method (ELAB) allows for the quantification of the absolute amounts of contained amino acids. The analysis is conducted twice, with the second analysis performed alongside standard amino acids. The provided data represents the DL analysis values after hydrolysis. However, the values also include a small amount of racemization that occurs during hydrolysis. The Enantiomer Labeling Method (ELAB) is a method that can accurately quantify amino acids such as Ser, Thr, Trp, and Tyr in peptides and proteins. The notes in the price list indicate the ideal conditions for obtaining more accurate values.

• Other contract services
• Ingredient analysis