三島国際貿易 List of Products and Services

We provide chromatography media based on precision manufacturing technology, including various substrates such as silica, polymers, and agarose, with properties such as affinity, ion exchange, hydrophobicity, normal phase, reverse phase, molecular sieves, or multimode, which assist in the purification of tagged proteins, antibodies, genes, vaccines, recombinant proteins, and plasma proteins.

• Separation device

Reversed-phase chromatography packing materials are part of a series of products designed for biological applications, based on monodisperse porous spherical silica with advanced surface modification and end-capping technologies. These reversed-phase chromatography packing materials feature high-density modification, good end-capping, uniform particle size, and high mechanical strength, and they are chemically stable (resistant to alkali), easy to pack, long-lasting, and exhibit excellent column performance, high resolution, and low back pressure. They are used for chromatographic analysis and large-scale separation and purification of organic compounds, natural products, and biomacromolecules. They offer advantages such as solvent savings through centralized cleaning, significantly reducing the costs of large-scale purification and contributing to improved cost performance and competitiveness of products.

• Chemicals

Normal-phase silica packing materials are manufactured using a unique patented technology and are designed for use in monodisperse, highly porous, high-purity silica chromatography columns. They can meet various needs such as high-efficiency liquid chromatography (HPLC) analysis and industrial production. They have high uniformity in particle size, are spherical in shape, possess excellent mechanical strength, and come in various specifications. Additionally, they are easy to pack into columns, offer high column efficiency, high resolution, and low pressure loss, making them widely used in chromatography analysis and industrial production of organic compounds, natural substances, and biopolymers. We offer four types of normal-phase silica chromatography packing materials: unmodified silica hydroxyl packing material, and three modified packing materials with bonded diol, aminopropyl, and cyano-propyl groups. These are used for the separation and purification of different polar compounds, making the separation of polar compounds particularly easy.

• Chemicals

The in vitro diagnostic microparticle products include the following: 1. Time-delayed fluorescent microparticles: By delaying the measurement time, it avoids interference from nonspecific fluorescence and improves detection sensitivity. 2. Fluorescent polystyrene microparticles: Monodisperse polystyrene microparticles containing high-brightness fluorescent dyes. 3. Particle size standard microparticles: A rich lineup ranging from 0.10μm to 200μm. 4. Non-magnetic fluorescent coding microparticles: Internally dyed fluorescent microparticles with red fluorescent coding. 5. White polystyrene microparticles: Particle size range from 0.05 to 50μm, with uniform particle size. 6. Colored polystyrene microparticles: The color of the microparticles is rich and stable due to internal coloring technology. 7. Magnetic polymer microparticles: The surface of the microparticles has very low nonspecific adsorption, suitable for developing highly sensitive biological detection methods. 8. Absolute count microparticles: Helps measure the absolute number of cells in a sample. 9. Magnetic silicon oxide microparticles: All are submicron size, and the hydrophilicity of the silicon oxide surface ensures good dispersion in water. 10. Chitosan microparticles: Internally structured with cross-linking, with a wide particle size distribution of 40 to 80μm. 11. Non-magnetic fluorescent coding microparticles: Internally dyed fluorescent non-magnetic microparticles.

• Other polymer materials

Polystyrene material, carboxyl group surface modification, particle size 4μm, red color in the APC fluorescence channel, with 8 types of fluorescent coding products ranging from intensity A to H available.

• Chemicals

Polystyrene material, carboxyl group surface modification, particle size 4μm, red color of the APC fluorescence channel, and a lineup of seven types of fluorescent coding products with intensities ranging from A to G.

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The interior of chitosan microparticles has a cross-linked structure, and the particle size distribution is broad, ranging from 40 to 80 μm. On the surface of the magnetic chitosan microparticles, Protein A or Ni-NTA affinity ligands are bound, and they are used in scenarios such as small-scale antibody/protein purification, immunoprecipitation, and pull-down experiments. Other functional groups and unmodified magnetic chitosan microparticles can also be offered as custom products.

• Chemicals

Magnetic polymer microparticles have a layered structure, with a porous polymer core inside and a polymer of different materials on the outside. The magnetic material is filled in the gaps between the layered structures. The particle size ranges from 1.0 to 20 μm and is very uniform, with a CV usually less than 3.0%. They are applied in various scenarios. The surface of the microparticles has very low nonspecific adsorption, making them particularly suitable for the development of highly sensitive biological detection methods, such as the development of magnetic microparticle chemiluminescent reagents. They can also be used in various fields such as immunoprecipitation, co-precipitation, cell magnetic separation, and nucleic acid specificity capture, among others in biomagnetic separation.

• Other polymer materials

Magnetic silica microparticles are all submicron in size, and the hydrophilicity of the silica surface ensures good dispersion of the microparticles in water. They are typically used for the extraction and purification of nucleic acids. The surface of the unmodified products has silica hydroxyl groups, allowing for the extraction of DNA and RNA from blood, cell culture media, animal and plant tissues, and forensic samples. Carboxyl group-modified products are suitable for applications such as the purification of PCR products and the selection of NGS fragments. Magnetic silica products modified with other functional groups (such as thiol groups, epoxy groups, etc.) are also available for custom orders.

• Chemicals

The silica microparticles in this series are non-porous spherical microparticles with a large specific surface area, a hydrophilic surface, and good dispersibility. Additionally, due to their excellent optical and mechanical properties, they are used in research areas such as the application of inorganic microparticles. Silica microparticles can be divided into two types: those that are unmodified and those that are modified with functional groups such as carboxyl, amino, and streptavidin affinity ligands. These are widely used in the separation of nucleic acids, cell separation, immunoassays, and other research fields.

• Chemicals

The standard particles for particle size are NIST traceable polystyrene microparticles with a highly uniform particle size. They are provided as a suspension with a solid content of 1.0% in a 10 mL titration bottle. Particles smaller than 1μm are measured by a centrifugal disk photometer (CPS), while particles larger than 1μm are measured by an electrical sensing zone (ESZ) method, calibrated with NIST traceable standard particles. Products in this series cover a particle size range from 0.10μm to 200μm and can accommodate various applications with a rich selection of size specifications.

• Chemicals

The flow absolute counting microparticle products are fluorescently stained microparticles or unstained microparticles with a particle size, provided as a suspension containing 1×10^6 microparticles per 1 mL. The microparticles are accurately counted using an electrical resistance particle counter and have a highly uniform particle size distribution and fluorescence intensity distribution (CV < 5%). Unstained absolute counting microparticles determine the absolute number of cells in the sample through scattered light signals. Internally stained fluorescent microparticles generate signals in common fluorescent channels such as FITC, PE, Cy5, APC, and Cy7, distinguishing them from the population of detected cells, and evaluating the ratio of detected fluorescent counting microparticles to cells to calculate the cell count. The product specifications for rainbow fluorescent microparticles with RB generate signals in all fluorescent channels and are suitable for cell counting in multicolor flow assays.

• Other polymer materials

Colored polystyrene microparticles based on white polystyrene microparticles are produced using a unique internal coloring technology. This internal coloring technology ensures that the color of the microparticles is rich and stable, and since the dye does not leak to the surface, it improves the efficiency of covalent bonding and detection sensitivity on the surface of the microparticles. Colored polystyrene microparticles modified with carboxyl groups bind to antigens, antibodies, and other substances through covalent bonds, and are widely used in lateral flow immunochromatography and emulsion agglutination tests. We offer a series of microparticle specifications that cover all colors of the rainbow, catering to various experimental needs in industrial and research fields.

• Chemicals

White polystyrene microparticle products are manufactured from polystyrene using emulsion polymerization and come in various sizes, with a particle size range from 0.05 to 50 μm, and have a uniform particle size. Polystyrene microparticle products without functional groups on their surface are suitable for binding with antigens and antibodies through physical adsorption. Polystyrene microparticle products modified with carboxyl groups can bind to ligands such as antigens/semi-antigens, antibodies, peptides, and nucleic acid probes through covalent bonds, making them ideal materials for immunodiagnosis and biological separation. Custom manufacturing with various particle sizes and functional groups is also possible, catering to diverse needs.

• Chemicals

Fluorescent polystyrene microparticles have fluorescent dyes embedded within the particles, effectively preventing the quenching of fluorescence and reducing the impact of environmental factors on fluorescence intensity. At the same time, the original functional groups are retained on the surface, which does not affect immunoassays, inspections, and other applications. The emission wavelength of this series of microparticles covers the entire visible light spectrum (from 460 nm to 750 nm), with the excitation wavelength being 30-40 nm lower than the emission wavelength. Fluorescent polystyrene microparticles are widely used in research fields such as side-flow chromatography, phagocytosis studies, pore size measurement, biochips, and microfluidic control. The emission spectrum of fluorescent microparticles is named based on the wavelength range of the fluorescence peak wavelength.

• Other polymer materials

Time-delayed fluorescent microparticles have a long fluorescence lifetime and exhibit a longer Stokes shift, which helps avoid interference from nonspecific fluorescence by delaying the measurement time, thereby improving detection sensitivity. The particle sizes of time-delayed fluorescent microparticles are available in three types: 0.1μm, 0.2μm, and 0.3μm, making them suitable for the development of immunochromatography products.

• Chemicals

Composite black microparticles of polymer and silicon dioxide stand out in blackness compared to products from other companies. There is no concern about fading, and they can meet special customer requirements. Currently, mainstream sizes such as 4.0µm and 6.0µm are being mass-produced, and products of other sizes can also be provided as custom orders with a delivery time of about two weeks. Product characteristics: * The particle size is very uniform, with a coefficient of variation (CV) of less than 3.5%. * Excellent monodispersity, with no overlap or aggregation. * High purity, with no contaminants. * High mechanical strength. * Excellent heat resistance, cold resistance, and chemical resistance.

• Composite Materials

Silicon microparticle products are very uniform in size regardless of particle diameter, and the coefficient of variation (CV) is controlled to be below 2.5%. They have a rich lineup and are widely used. Product characteristics: * The particle size is very uniform, with a coefficient of variation (CV) of less than 2.5%. * Excellent monodispersity, with no overlap or aggregation. * High purity with no contaminants. * High mechanical strength, K > 4500. * Excellent heat resistance, cold resistance, and chemical resistance.

• LCD display

These are monodisperse microparticles made from highly cross-linked polymers, available in a rich variety of specifications with fine size increments, and are widely used in fields such as LCD and PDLC. They are measured using certified measuring instruments (Beckman Coulter Counter Multisizer) and certified methods, and to ensure measurement accuracy, they are calibrated with traceable standard particles from NIST before each measurement. Since the ion content of microparticle products can directly affect the quality of liquid crystals, deionized water is used in the manufacturing and cleaning processes, and products are regularly sampled and inspected. The manufacturing process does not use substances prohibited by the European Union RoHS directive, and does not contain organic compounds or heavy metals banned by RoHS. Product characteristics: * The particle size is very uniform, with a coefficient of variation (CV) of less than 3.5%. * It has excellent monodispersity, with no overlap or aggregation. * It has high purity and contains no contaminants. * It has high mechanical strength. * It possesses excellent heat resistance, cold resistance, and chemical resistance.

• Other polymer materials

Nickel-coated conductive microparticles are designed for connections between fine electrodes and are used, for example, for vertical conduction between glass plates in liquid crystal display panels. They are also used to create anisotropic conductive films (ACF) dispersed in adhesives or as anisotropic conductive adhesives (ACP) in the assembly of liquid crystal displays. Product characteristics: ★ Core made of polymer microbeads with a nickel layer as the shell. ★ A wide range of particle size options: a rich lineup of specifications in increments of 0.25 µm within the range of 3.0 to 11.0 µm. ★ Uniform particle size with a coefficient of variation (CV) of less than 3.5%. ★ Excellent dispersibility with no overlap or aggregation. ★ Possesses appropriate hardness, stable conductivity, and reliability. ★ Low impedance and high stability even in high-temperature and high-humidity environments.

• Other polymer materials

It is used for vertical conduction between glass plates of liquid crystal display panels, and is also used to create anisotropic conductive films (ACF) dispersed in adhesives, or as anisotropic conductive adhesives (ACP) for the assembly of liquid crystal displays. Product characteristics: ★ Core made of polymer microbeads, with a gold film as the outer shell. ★ A wide range of particle size options: a rich lineup with specifications in increments of 0.25 µm within the range of 3.0 to 11.0 µm. ★ Uniform particle size, with a coefficient of variation (CV) of less than 3.5%. ★ Excellent dispersibility, with no overlap or aggregation. ★ Has appropriate hardness, stable conductivity, and reliability. ★ Low impedance and high stability even in high temperature and humidity environments.

• Other polymer materials

We offer a lineup of light-diffusing particulate products made from monodisperse organic polymer particles such as PMMA, PS, and P(MMA/S), as well as organic silicon. Product characteristics: * Uniform particle size; * Narrow particle size distribution; * Good dispersibility with no overlap or aggregation; * High light diffusion efficiency; * High purity with no contamination; * Excellent heat resistance; * Good compatibility, allowing for efficient dispersion in substrates; * High mechanical strength and height; * Good chemical stability; * Insoluble in organic solvents; * High transmittance with adjustable refractive index. Product technical specifications: Appearance: Pure white Shape: Spherical Water content: < 2% Refractive index: Organic polymer particles: 1.49 - 1.59 Organic silicon particles: 1.43 Density (25°C): Organic polymer particles: 1.05 - 1.20 g/ml Organic silicon particles: 1.32 - 1.43 g/ml Heat resistance: Organic polymer particles: 250 - 270 °C Organic silicon particles: 350 °C (weight loss 2-3%)

• Other polymer materials

We offer a lineup of microparticles with the following characteristics, and we can also accommodate custom orders as needed. 1. Monodisperse microparticles made of organic, inorganic, and composite materials in any size within the range of 1.5 nm to 1000 μm. 2. Microparticles in various forms such as hollow, porous, core-filled, and solid. (Pore size and specific surface area can be controlled as needed within the range of 3-800 nm.) 3. Microparticles with functional groups of different types and densities bonded to their surfaces, enhancing dispersibility and improving the adsorption selectivity and affinity of the microsphere surface. 4. Microparticles whose photoelectromagnetic properties and mechanical strength are controlled by varying material compositions. 5. Mass production technology for microparticles: This leads to shorter delivery times and cost reductions through mass production techniques. They are widely used in the following fields: Liquid crystal spacers, ACF, optical films, surface finishing agents, lithium batteries, heavy metal absorption, water treatment, LEDs, solar panels, standard microparticles, HPLC analysis columns, solid-phase extraction, fluorescent microparticles, and magnetic beads. For more details, please download the catalog, view related links, or contact us.

• Other polymer materials

Mishima International Trading Co., Ltd. is collaborating with leading manufacturers in China to procure the following products. We can produce large cast aluminum housings sized approximately 1926x670x536 for high-pressure transport electrical systems. We are fully equipped with machining facilities and inspection equipment, ensuring you can trust our machining and quality assurance. *For more details, please download the PDF materials or feel free to contact us.

• Processing Contract

Mishima International Trading Co., Ltd. is collaborating with leading manufacturers in China to handle the procurement of the following products. We can manufacture cast aluminum products used in high-pressure transmission systems. We are fully equipped with machining facilities and inspection equipment, ensuring you can trust our machining and quality assurance. *For more details, please download the PDF materials or feel free to contact us.

• Control Panel

Mishima International Trading Co., Ltd. is collaborating with leading manufacturers in China to handle the procurement of the following products. We can produce large and complex aluminum products, such as flow meter parts, weighing up to 500 kg. We are fully equipped with machining facilities and inspection equipment, ensuring you can trust our machining and quality assurance. *For more details, please download the PDF document or feel free to contact us.

• Contract manufacturing

Mishima International Trading Co., Ltd. is collaborating with leading manufacturers in China to handle the procurement of the following products. We can manufacture large and complex aluminum products weighing approximately 44.4 kg. We are fully equipped with machining facilities and inspection equipment, ensuring you can trust our machining and quality assurance. *For more details, please download the PDF document or feel free to contact us.

• Other industrial robots

Mishima International Trading Co., Ltd. is collaborating with leading manufacturers in China to handle the procurement of the following products. We can manufacture large and complex aluminum products approximately 1500 mm in size. We are fully equipped with machining facilities and inspection equipment, ensuring you can trust our machining and quality assurance. *For more details, please download the PDF materials or feel free to contact us.

• Switching Power Supply

Mishima International Trading Co., Ltd. is collaborating with leading manufacturers in China to handle the procurement of the following products. We have high-pressure equipment ranging from 400 tons to 3500 tons and manufacture die-cast products. In addition to die-cast products like the gear housing shown in the image, we also accept orders for other items. We are fully equipped with machining facilities and inspection equipment, ensuring you can trust our machining and quality assurance. *For more details, please download the PDF document or feel free to contact us.

• Transmission parts

Aluminum casting is a process used to manufacture aluminum products with complex shapes by employing various casting methods such as sand casting, metal mold casting, and low-pressure casting, depending on the product's shape and size. We are currently offering a free collection of case studies that detail examples of available products along with product photos! 【Table of Contents】 ■ Passenger car parts (gravity casting) ■ Commercial vehicle parts (gravity casting) ■ Low-pressure aluminum casting parts ■ Die-cast products ■ Sample production ■ Gravity and low-pressure aluminum casting equipment ■ High-pressure aluminum casting (die-casting) equipment ■ Inspection equipment *For more details, please download the PDF materials or feel free to contact us.

• Contract manufacturing

Mishima International Trading Co., Ltd. is supported by the China Foundry Association and collaborates with appropriate foundry manufacturers in various regions of China to maximize the range of products that can be manufactured and ensure quality assurance. We accept orders for the production of Chinese castings for Japanese manufacturers of machinery and equipment. We handle not only cast iron products but also cast steel products, aluminum castings, die-cast products, etc., based on customer drawings, from mold making to casting and machining, and we aim to assist Japanese manufacturers in their material procurement. Please feel free to contact us with your requests. 【Product Examples】 ■ Parts for air separation equipment ■ Weight: 40 tons ■ Material: FC-250 *For more details, please refer to the related links or feel free to contact us.

• Contract manufacturing

Maintaining oral hygiene primarily focused on teeth is not easy. We propose a convenient oral irrigator that can be used at home or while out. * Most products come with a water tank, but if the tank is large, it can cause issues with placement and mobility. If the tank is small, refilling can be difficult, and since it is integrated, it can feel heavy. This product can use any cup as a water tank, allowing for easy refilling and convenient storage and movement! * Compact storage and portable, so you can take care of your oral hygiene without worry, not just at home but also when you are out. * Charging is as simple as placing it on the stand, and it is USB compatible.

• Other cleaning machines

We accept consignment processing of FKM material O-rings. Please feel free to contact us for other FKM products as well.

• Sealing

The era has come where the properties of engineering plastics (such as insulation, corrosion resistance, heat resistance, non-magnetism, and lightweight) can be utilized in fields such as chemical engineering, medical and pharmaceutical, food machinery, and mechanical equipment. Available materials include PEEK, PPS, PVDF, PP, RENY, PVC, NYLON, PTFE, PEI, TPI, PPGF, and PEEK+GF. We also have standardized products such as fasteners like screws, nuts, and washers, engineering plastic bearings, composite boards, and threads. In addition, we offer custom products through pressing and machining based on drawings. We deliver from Taiwan, which boasts globally high quality in engineering plastics. For more details, please download and view the catalog.

• Other semiconductor manufacturing equipment

We will accept orders for the following Chinese-made high-strength bolts. Stock sales are also possible based on demand planning. High-strength hex bolts for friction joints (JIS B1186 F10T) have obtained TUV certification. The bolts come in lengths of M16, M20, M22, M24, M27, and M30, each set includes 1 bolt, 1 nut, and 2 washers. We also accept custom orders for any tightening bolts and screw products based on customer drawings.

• bolt