常磐植物化学研究所 List of Products and Services

The Tokiwa Botanical Research Institute's TW series of traditional Japanese and Chinese herbal complex extracts is an original extract developed based on traditional Chinese medicine formulations for application in food. It features a total of five extracts that align with the "Theory of Qi, Blood, and Water," established in the Edo period, which emphasizes maintaining the balance of Qi, water, and blood to support overall health. To maximize the effectiveness of the herbal ingredients, we adhere to traditional methods of Chinese medicine. These extracts can be incorporated into supplements as well as general food products such as soups and candies. ◆Properties Extract powder ◆Applicable Categories Food ◆Certification Manufactured in our own factory, which has obtained JIHFS health food raw material GMP and Codex standard HACCP certification. ◆Product Lineup TW-KK, TW-TU, TW-SE1, TW-SS, TW-D1 *Details are provided in the "Basic Information" section below.

• Organic Natural Materials

Laresh is an extract powder made from laurel leaves. It is a tokiwa original material aimed at oral care and is currently attracting attention. ◆ Source Plant Laurel (Laurus nobilis L.) Family: Lauraceae ◆ Standard Components Deacetyl laurenobiolide ◆ Properties Extract powder ◆ Applicable Categories Food, Cosmetics ◆ Abundant Evidence Antiplaque action, anticaries action, suppression of anaerobic bacteria proliferation in the oral cavity, breath odor suppression action ◆ Certification Manufactured in our own factory, which has obtained JIHFS health food raw material GMP and Codex standard HACCP certification.

• Organic Natural Materials

Tiacalon is an extract and refined powder of green tea, standardized for catechins. It is a functional food ingredient that claims to "reduce abdominal fat," has a record of acceptance, and is currently attracting attention. ◆ Source Plant Green tea (Camellia sinensis L.) Family: Theaceae ◆ Standard Components Catechins ◆ Form Extract powder ◆ Corresponding Category Food (functional food ingredient) ◆ Example of Functional Food Notification It has been reported that tea catechins (as gallate-type catechins) have the function of reducing abdominal fat (visceral fat and subcutaneous fat) in individuals who are prone to obesity. ◆ Expected Effects Reduction of abdominal fat ◆ Certification Manufactured at our own factory, which has obtained JIHFS health food raw material GMP and Codex standard HACCP certification.

• Organic Natural Materials

IsoMax is an extract powder made from soybeans, standardized for isoflavone glycosides. It is a material suitable for functional food labeling that promotes "maintaining bone components," and it has a track record of acceptance, currently attracting attention. ◆ Source Plant Soybean (Glycine max L.) Family: Leguminosae ◆ Standard Components Isoflavone glycosides ◆ Properties Extract powder ◆ Corresponding Category Food (suitable for functional food labeling) ◆ Example of Functional Food Labeling It has been reported that soybean isoflavones have a function that helps maintain bone components. This product is suitable for those who want to maintain strong bones. ◆ Expected Effects Maintenance of bone components ◆ Certification Manufactured in our own factory, which has obtained JIHFS health food raw material GMP and Codex standard HACCP certification.

• Organic Natural Materials

Corosolic acid is an extract and refined powder derived from the leaves of the Banaba plant. It is a functional food ingredient that claims to "lower fasting blood sugar levels," has a history of acceptance, and is currently attracting attention. ◆ Source Plant Banaba (Lagerstroemia speciosa Pers) Family: Lythraceae ◆ Standard Components Corosolic acid ◆ Properties Extract powder ◆ Corresponding Category Food (functional food ingredient) ◆ Example of Functional Food Notification Corosolic acid derived from Banaba leaves has been reported to lower elevated fasting blood sugar levels in healthy individuals. It is suitable for those with higher fasting blood sugar levels. ◆ Expected Effects Improvement of fasting blood sugar levels ◆ Certification Information Manufactured in our own factory, which has obtained JIHFS Health Food Raw Material GMP and Codex standard HACCP certification.

• Organic Natural Materials

Ginger warmer is an extract powder made from ginger. It is a functional food ingredient that claims to maintain peripheral body temperature in low-temperature environments, and it has a record of acceptance, currently attracting attention. The unique spicy flavor of ginger adds an accent. It features high sensory perception and dispersibility, making it suitable not only for supplements but also for soups and drinks. ◆ Source Plant Ginger (Zingiber officinale) Family: Zingiberaceae Genus: Zingiber ◆ Standard Components Ginger-derived polyphenols (6-gingerol, 6-shogaol) ◆ Properties Extract powder ◆ Corresponding Category Food (functional food ingredient) ◆ Example of Functional Food Notification It has been reported that ginger-derived polyphenols (6-gingerol, 6-shogaol) have the function of maintaining peripheral body temperature in low-temperature environments. ◆ Expected Effects Maintaining peripheral body temperature in low-temperature environments ◆ Certification Manufactured at our own factory, which has obtained JIHFS health food raw material GMP and Codex standard HACCP certification.

• Organic Natural Materials

Sartomax is an extract and refined powder of black turmeric. It is a recommended ingredient by Tokiwa, having obtained various evidence, including blood sugar improvement, through our unique clinical trials and in vitro tests. ◆ Source Plant Black Turmeric (Kaempferia parviflora) Family: Zingiberaceae Genus: Kaempferia ◆ Standard Components 3,5,7,3’,4’-Pentamethoxyflavone (PURESIRTMAX), total polymethoxyflavonoids ◆ Properties Extract powder ◆ Corresponding Category Food (compliant with functional food labeling) ◆ Abundant Evidence Blood sugar improvement, eye moisture support, skin quality improvement, activation of sirtuin genes (longevity genes), anti-glycation effects ◆ Intellectual Property Sirtuin activator (domestic patent: Patent No. 6417630, US patent: Patent No. 9,745,279 B2) ◆ Certification Manufactured at our own factory, which has obtained JIHFS health food raw material GMP and Codex standard HACCP certification.

• Organic Natural Materials

Ginkoron is an extract powder made from ginkgo leaves. Tokiwa is the company that "developed ginkgo leaf extract for the first time in Japan" and "provided bulk supply for the first time in the world." The ginkgo leaves used in Ginkoron are sourced from both domestic and New Zealand origins, and it has a strong track record as a functional food product, attracting attention. ◆ Source Plant Ginkgo (Ginkgo biloba L.) Family: Ginkgoaceae ◆ Standard Components Total flavonoid glycosides, total terpene lactones ◆ Characteristics Extract powder ◆ Corresponding Category Food (compatible with functional food labeling) ◆ Example of Functional Food Labeling Notification Flavonoid glycosides derived from ginkgo leaves and terpene lactones derived from ginkgo leaves have been reported to improve blood flow to the brain, which decreases with age, and to maintain memory (the ability to remember and recall words and shapes encountered in daily life), which is part of cognitive function. ◆ Certification Information It is manufactured at our own factory, which has obtained JIHFS health food raw material GMP and Codex standard HACCP certification.

• Organic Natural Materials

Bilberon is an extract powder derived from bilberry fruit, and we have obtained various evidence, including eye care claims, through our unique clinical trials. It has also gained attention for its numerous acceptance records as a functional food product. ◆ Source Plant Bilberry (Vaccinium myrtillus L.) Family: Ericaceae ◆ Standard Components Anthocyanins ◆ Properties Extract powder ◆ Corresponding Category Food (compatible with functional food labeling) ◆ Examples of Functional Food Labeling Notifications (1) Bilberry-derived anthocyanins have been reported to support focusing ability, alleviate eye fatigue, and reduce temporary neck and shoulder strain caused by eye use. (2) Bilberry-derived anthocyanins have been reported to support focusing ability and provide moisture to the eyes, which is often lacking during VDT work (monitor work such as computers and smartphones), alleviating eye fatigue. ◆ Certification Manufactured in our own factory, which has obtained JIHFS health food raw material GMP and Codex standard HACCP certification.

• Organic Natural Materials

Benetron is an extract powder made from the leaves of Apocynum venetum, which has obtained various evidence, including sleep improvement, through our unique clinical trials and animal studies. It is an original ingredient from Tokiwa that is currently attracting attention as a plant-derived sleep improvement material, with many acceptance records as a functional food. ◆ Source Plant Apocynum venetum L. Family: Apocynaceae ◆ Standard Components Hyperoside, Isoquercitrin ◆ Form Extract powder ◆ Corresponding Category Food (compatible with functional food labeling) ◆ Example of Functional Food Notification Label This product contains hyperoside and isoquercitrin derived from Apocynum. It has been reported that hyperoside and isoquercitrin derived from Apocynum can help improve sleep quality (depth of sleep and satisfaction with sleep upon waking). ◆ Abundant Evidence Effects on sleep improvement, attention support, stress relief, improvement of depressive symptoms, improvement of PMS and menopausal symptoms, etc. ◆ Certification Manufactured at our factory, which has obtained JIHFS health food raw material GMP and Codex standard HACCP certification.

• Organic Natural Materials

We have equipped ourselves with various devices to meet the diverse requests for component purification from materials received from our customers. Even for the purification of components that are present in only trace amounts within the materials, our factory's extraction equipment allows for extraction from large quantities of raw materials. By combining precise purification through high-speed liquid chromatography and medium-pressure liquid chromatography, we carry out the purification of trace components. We can accommodate purification on a scale of a few milligrams to grams, tailored to our customers' objectives. ◆ Are you facing any of these issues? ◆ - I want high-purity compounds for analysis that are not commercially available. - I need high-purity plant components in gram quantities for animal experiments. - I want to isolate and purify extremely small amounts of plant components. - I want to perform extraction and purification on a scale that is challenging for my lab. We respond to customer requests with well-equipped facilities, advanced technology, and extensive experience. Please feel free to consult with us.

• Organic Natural Materials