Trans Chromosomics List of Products and Services

The TC-huMDR1TM mouse is a trans-chromosomic (Tc: chromosomal insertion) mouse (B6 strain) that introduces the human MDR1 gene into a mouse that has knocked out the intrinsic mdr1a/1b genes (mMDR1-KOTM) using an "artificial chromosome vector," making it the world's first 'human-type P-gp model mouse' that expresses functional P-glycoprotein (P-gp). Features and Benefits: * Functional human P-gp protein is expressed. * The AUC of TC-huMDR1TM mice and mMDR1-KOTM mice can be used to evaluate human brain permeability and P-gp-mediated drug-drug interactions. * Using TC-huMDR1TM mice and physiological pharmacokinetic (PBPK) modeling, quantitative predictions of human nonlinear absorption mediated by P-gp can be made. * This allows for the selection of compounds with ideal pharmacokinetic profiles in drug discovery, facilitating more appropriate management of P-gp-mediated drug-drug interactions in clinical settings. *For more details, please refer to the PDF materials or feel free to contact us.*

• Other experimental equipment and supplies
• Other experimental consumables
• Other animal and plant experimental equipment and instruments

Antibodies recognize foreign substances from the outside, activating the immune system and producing B cells. If you want to create human antibodies against a specific protein, due to ethical issues, it is not possible to administer the protein to humans to obtain antibody-producing cells. Traditionally, to produce antibodies against humans, the target protein was administered to animals like mice, whose immune systems would respond, allowing for the collection of antibody-producing cells. Then, the antigen recognition site would be analyzed, and the human antibody region would be substituted in a process called "humanization." When constructing human antibody-producing cells, the human antibody-producing gene is introduced into rat cells via a plasmid. The plasmid integrates into the host's chromosomes, which poses a problem as it can disrupt the function of other genes. Our company has successfully introduced a large human antibody-producing artificial chromosome vector into rat cells using chromosome engineering technology, allowing it to be stably maintained independently. 【Features】 ■ Rapid acquisition of human antibody-producing cells is possible ■ Increased potential to obtain antibody drug candidates *For more details, please refer to the catalog or feel free to contact us.

• Other Nucleic Acid/DNA Research

We have created human-like drug metabolism model mice and rats equipped with artificial chromosome vectors carrying human drug metabolism-related genes. By administering new drugs, we can predict safety for humans, leading to accelerated pharmaceutical development and reduced costs. 【Features】 ■ Improved prediction of safety for humans ■ Accelerated pharmaceutical development and increased success rates ■ Lower costs for new drug development and reduced national healthcare burden *For more details, please refer to the catalog or feel free to contact us.

• Other experimental equipment

TransChromosomics Co., Ltd. is a bio-venture originating from Tottori University, established with the aim of developing drug discovery and drug discovery support tools, based on the know-how of chromosome engineering technology acquired by CEO Mitsuo Oshimura during his 30 years of research. Using cutting-edge chromosome engineering technology, we conduct chromosome modifications, iPS/ES cell production, genetically modified mouse and rat production, animal testing, antibody production, and more. 【Business Activities】 ■ Development of fully human antibody-producing rats ■ Development of genetic rare disease model animals and cell transplantation therapy ■ Development of human-like drug metabolism model animals ■ Contract testing For contract testing inquiries or questions, please use the contact form. You can also reach us through our official website. http://trans-chromo.wix.com/trans-chromosomics *For more details, please refer to our catalog or feel free to contact us.

• Other Testing Contract