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  3. トランスジェニック
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Pharmaceuticals and Biotechnology
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トランスジェニック

addressTokyo/Chiyoda-ku/4th Floor, South Building, Yurakucho Denki Building, 1-7-1 Yurakucho
phone078-306-0590
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last updated:Oct 17, 2024
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トランスジェニック List of Products and Services

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CRO "Pharmacological Efficacy Testing"

Pharmacological tests can evaluate memory learning ability, cerebral infarction, brain tumors, and more!

This is one of the pharmacological tests related to the central nervous system, evaluating the effects of pharmaceuticals and health foods on brain function using small animals. [Test Types] ■ Evaluation of memory and learning ability - Scopolamine model ■ Evaluation of memory and learning ability - Amyloid β model ■ Evaluation of memory and learning ability - Accelerated aging mice (SAMP8) ■ Evaluation of cerebral infarction and brain tumors, etc. *For more details, please refer to the catalog or feel free to contact us.

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『GeneChipTranscriptomeArray2.0』

The definitive version of next-generation microarrays! Visual and easy-to-understand analysis will be possible!

The GeneChip Transcriptome Array 2.0 analysis covers over 285,000 full-length transcripts and allows for visually clear analysis using the Transcriptome Analysis Console (TAC) Software. Probes are designed not only for exon regions but also for junction areas. 【For customers like these】 ■ Want to perform gene expression analysis using microarrays ■ Want to analyze the expression of non-coding transcripts as well as coding transcripts ■ Want to try it as a pre-test before next-generation sequencing analysis, etc. *For more details, please refer to the catalog or feel free to contact us.

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Contracted Mouse Services: "Conditional Knockout Mouse Production"

It is a very effective method for analyzing gene functions!

This service will create mice that have a gene locus flanked by the Cre recombinase target sequence loxP, targeting specific gene regions. By crossing these mice with mice that express Cre recombinase in a tissue- and time-specific manner, it is possible to induce the destruction of the target gene only in specific tissues and at specific times. 【Features】 ■ Contains loxP sequences, allowing gene destruction through the expression of Cre recombinase ■ Enables lethal gene analysis ■ Allows tissue-specific gene destruction ■ Allows time-specific gene destruction *For more details, please refer to the catalog or feel free to contact us.

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Antibody Production: "GANP Monoclonal Antibody Production"

For those seeking antibodies with high affinity and high specificity! Leave it to us!

The GANP mouse technology is a method for producing antibodies using "GANP mice," which have a genetic background that allows for a high frequency of mutations in the variable regions of antibodies. Antibodies obtained from GANP mice are characterized by a higher affinity and specificity due to the increased mutations compared to those produced using wild-type mice. This technology enables the production of antibodies that recognize amino acid modifications, as well as the development of diagnostic reagents and antibody drugs. 【For customers like this】 ■ Want to establish recognition antibodies at the amino acid level ■ Want to detect small molecules ■ Want to detect only one molecule belonging to a protein superfamily ■ Want to obtain antibodies with higher affinity than existing antibodies, etc. *For more details, please refer to the catalog or feel free to contact us. *Our company is a group company of Transgenic Inc. and is engaged in contract research for this service.

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Assessment of treatment effects and prognosis prediction after drug administration: "CTC measurement"

Count the number of cancer cells flowing in the bloodstream! Monitoring is possible!

It is possible to count the number of cancer cells circulating in peripheral blood and monitor cancer prognosis using a minimally invasive method. 【For customers like this】 ■ Want to assess the necessity of aggressive treatment before therapy ■ Want to evaluate treatment effectiveness after starting chemotherapy ■ Want to assess markers from cells that have infiltrated into the bloodstream from primary tumor tissue or metastatic tumor tissue, etc. *For more details, please refer to the catalog or feel free to contact us.

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Pharmacological Efficacy Testing Individual 'Pharmacological Tests on Cardiovascular/Metabolic Diseases'

Analysis of anti-obesity effects is possible using a mouse model of dietary obesity!

We will evaluate pharmaceuticals and health foods related to circulatory and metabolic diseases using systems involving small and large animals. 【Main Items】 ■ Myocardial Infarction Model ■ Diabetes Model ■ Anti-Obesity Effects ■ Atherosclerosis Model *For more details, please refer to the PDF document or feel free to contact us.

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Pharmacological efficacy test Individual 'Pharmacological test related to immunity'

It is possible to study the effects of food ingredients on the immune balance in the body using mice, focusing on acquired and innate immunity as well as intestinal immunity!

We will evaluate the effects of pharmaceuticals and health foods on immunity, atopic dermatitis, and skin photoaging using a small animal model. 【Main Items】 ■ Evaluation of immune balance and intestinal immunity ■ In vivo evaluation using mice ■ Evaluation using atopic dermatitis mice *For more details, please refer to the PDF document or feel free to contact us.

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Pharmaceutical Clinical Trials Individual 'Pharmaceutical Clinical Trials'

We will conduct this in accordance with the guidelines for biological equivalence for generic drugs of locally applied dermatological formulations!

We will introduce pharmacological tests in the approval applications for the development of generic drugs, changes in prescriptions, and the addition of dosage forms. 【Features】 ■ Bioequivalence tests for topical dermatological formulations ■ Dermatokinetics tests (DPK tests) ■ Pharmacological tests (measurement of stratum corneum moisture content) *For more details, please refer to the PDF materials or feel free to contact us.

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Technical Data: Pharmacokinetic Studies Using Monkeys

Published on pharmacological efficacy testing! Methods and application examples are detailed with the use of illustrations.

This document provides an overview of the methods and applications in "pharmacokinetic studies using monkeys." Key topics include "administration methods, sample collection," "gastrointestinal absorption and metabolism evaluation tests," and "blood-brain barrier permeability tests." Additionally, our company offers consulting services for the construction of test systems tailored to customer needs, based on our extensive experience. Please feel free to contact us. [Contents] ■ Key Topics ■ For Customers Like These ■ Administration Methods and Sample Collection Methods ■ Gastrointestinal Absorption and Metabolism Evaluation Tests ■ Blood-Brain Barrier Permeability Tests *For more details, please refer to the PDF document or feel free to contact us.

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[Technical Document] Drug Testing Using Monkeys - 1 (Urology, Periodontal Disease)

It includes evaluations of bladder function and results of studies on the effects against periodontal disease.

This document introduces the "Evaluation of Pharmaceuticals and Health Foods Related to Urology or Periodontal Disease." Our company provides consulting for the construction of testing systems tailored to customer needs, based on our extensive experience. Please feel free to contact us. 【Contents】 ■ Main Items ■ For Customers Like This ■ Evaluation of Bladder Function in Monkeys ■ Evaluation Using a Low-Activity Bladder Model in Monkeys ■ Evaluation Using a Periodontal Disease Model in Monkeys *For more details, please refer to the PDF document or feel free to contact us.

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Technical Document: Drug Testing Using Monkeys - 2 (Microdialysis)

Numerous achievements in various parts of the brain! Introducing the continuous collection method that has been implemented for a long time.

This document introduces "Evaluation of Brain Penetration Using Microdialysis Method." The microdialysis method has been implemented for a long time using small animals such as mice and rats, primarily in the field of neurophysiology, as a continuous recovery method for neurotransmitters such as acetylcholine and dopamine. To respond to the diversification of recent drug discovery seeds, it is often desired to use primates, which are closer to humans and possess higher brain functions, for early evaluation of pharmacokinetics extrapolated to humans and the dynamics of neurotransmitters induced by drugs. [Contents] ■ Main Items ■ For Customers Like This ■ Evaluation of Brain Penetration Using Microdialysis Method ■ MRI Imaging ■ Cerebrospinal Fluid Collection (CSF) ■ Others *For more details, please refer to the PDF document or feel free to contact us.

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[Data] List of Safety Tests and Contract Tests

We will provide a detailed introduction to contract testing using mice, rats, guinea pigs, monkeys, and other animals.

This document is a list of "Safety Tests and Contract Tests" conducted by Shin-Yaku Research Center Co., Ltd. We offer various tests including "Single Dose Toxicity Test" and "Repeated Dose Toxicity Test" using mice and rats, as well as medical device safety tests and safety pharmacology tests. [Contents] ■ Pharmaceutical Safety Tests ■ Medical Device Safety Tests ■ Chemical Substance Safety Tests ■ Food Safety Tests ■ Safety Pharmacology Tests ■ GLP Compliance Status *For more details, please refer to the PDF document or feel free to contact us.

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Technical Document: Pharmaceutical Clinical Trial 1

Publication on bioequivalence testing in approval applications for the development of generic drugs and additional dosage forms.

This document introduces "Bioequivalence Testing (Comparison of Pharmacokinetics)." Our company provides comprehensive support for bioequivalence (BE) testing conducted by healthy adults in the development of generic pharmaceuticals, from clinical trials to pharmacokinetic measurements and the preparation of summary reports. We conduct bioequivalence (BE) testing not only for oral formulations but also for topical formulations. For topical products, we can also perform pharmacological tests such as skin pharmacokinetic studies, blanching tests, residual amount tests, and patch tests. [Contents] ■ Main Items ■ For Customers Like This ■ 1) Bioequivalence Testing (Comparison of Pharmacokinetics) *For more details, please refer to the PDF document or feel free to contact us.

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Technical Document: Pharmaceutical Clinical Trial 3

Leave the skin safety tests, herbal formulations, OTC products, quasi-drugs, and cosmetics testing to us.

This document introduces skin safety tests and various clinical trials related to the approval applications for the development of generic topical pharmaceuticals, changes in formulations, and the addition of dosage forms. Our company provides comprehensive support for the development of generic pharmaceuticals, including bioequivalence (BE) studies conducted with healthy adults, from clinical trials to pharmacokinetic measurements and the preparation of summary reports. We conduct bioequivalence (BE) studies not only for oral medications but also for topical preparations. For topical formulations, we can perform pharmacological tests such as skin pharmacokinetic studies and blanching tests, as well as residual quantity tests and patch tests. [Contents] - Features - For customers like this - 3) Skin safety tests (patch tests) - Testing for herbal preparations, OTC products, quasi-drugs, and cosmetics - Other clinical trials targeting healthy adults *For more details, please refer to the PDF document or feel free to contact us.

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[Information] List of Contracted Clinical Trials and Services in Pharmaceuticals

We provide detailed information about the clinical trial and services conducted by our company.

This document introduces the list of contract clinical trials and services conducted by Shin-Yaku Research Center Co., Ltd. In the "Support for the Business of Bioequivalence Testing for Topical Dermatological Preparations," we also offer skin pharmacokinetic tests (DPK tests), pharmacological tests (measurement of skin blanching), and pharmacological tests (measurement of skin stratum corneum moisture content). [Contract Business Contents] ■1) Support for Bioequivalence Testing ■2) Support for Bioequivalence Testing for Topical Dermatological Preparations - Skin Pharmacokinetic Tests (DPK Tests) - Pharmacological Tests (Measurement of Skin Blanching) - Pharmacological Tests (Measurement of Skin Stratum Corneum Moisture Content) ■3) Support for Skin Safety Testing (Patch Tests) ■4) Support for Testing of Herbal Preparations, OTC Products, Quasi-drugs, and Cosmetics ■5) Support for Other Clinical Trials Targeting Healthy Adults *For more details, please refer to the PDF document or feel free to contact us.

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Technical Data: General Toxicity Test

We will evaluate the general toxicity of pharmaceuticals and health foods using a small animal model.

This document introduces "general toxicity testing." Our company evaluates the general toxicity of pharmaceuticals and health foods using small animal models. We conduct "single-dose toxicity tests" and "repeated-dose toxicity tests" to identify toxic doses based on testing items. [Contents] ■ Main items ■ Single-dose toxicity test ■ Repeated-dose toxicity test *For more details, please refer to the PDF document or feel free to contact us.

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Technical Data: Rabbit Eye Wear Test (Contact Lens Wear Test)

Please leave the rabbit eye implant tests and the rabbit eye implant eye drop administration tests to us.

This document introduces the "Ocular Wear Test for Rabbits (Contact Lens Wear Test)." Our company evaluates the safety of contact lenses and protective products for contact lenses on the eyes. We also evaluate the eye drop administration test during contact lens wear. [Contents] ■ Main Items ■ For Customers Like This ■ Ocular Wear Test for Rabbits ■ Ocular Wear Eye Drop Administration Test *For more details, please refer to the PDF document or feel free to contact us.

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Technical Data: Sensitization, Phototoxicity, Antigenicity Tests

Evaluation using small animals. Leave the testing of pharmaceuticals and health foods to us.

This document introduces "sensitization, phototoxicity, and antigenicity testing." Our company evaluates the sensitization, phototoxicity, and antigenicity of pharmaceuticals and health foods using small animal models. We also conduct various safety tests for chemical substances and prepare research papers. [Contents] ■ Main Items ■ For Customers Like This ■ Skin Sensitization Test, Skin Phototoxicity Test ■ Phototoxicity Test ■ Antigenicity Test *For more details, please refer to the PDF document or feel free to contact us.

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[Technical Data] Pharmacological Tests on Acute and Chronic Inflammation

We will evaluate using a small animal model regarding assessments related to rheumatism and arthritis.

This document introduces "Pharmacological Studies on Acute and Chronic Inflammation." Our company evaluates inflammation, rheumatism, and arthritis related to pharmaceuticals and health foods using small animal models. In addition to the created disease model animals and naturally occurring disease model animals, it is also possible to obtain congenic animals for testing. [Contents] ■ Main Items ■ For Customers Like This ■ Acute and Chronic Inflammation Models ■ Collagen-Induced Arthritis Models (Rats, Mice, Monkeys) ■ Rabbit Osteoarthritis (OA) Model ■ Rat Monoiodoacetate (MIA) Induced Osteoarthritis (OA) Model *For more details, please refer to the PDF document or feel free to contact us.

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Technical Data: Local Irritation Test

We will evaluate the irritancy of pharmaceuticals using a rabbit model.

This document introduces the "Local Irritation Test." Our company primarily evaluates the irritancy of pharmaceuticals using a rabbit model. We also conduct various safety tests for chemical substances and prepare research papers. For more details, please contact us. 【Contents】 ■ Main Items ■ For Customers Like This ■ Primary Skin Irritation and Cumulative Skin Irritation Tests ■ Eye Mucosa, Oral Mucosa, and Rectal Mucosa Irritation Tests ■ Muscle Irritation and Vascular Irritation Tests *For more details, please refer to the PDF document or feel free to contact us.

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[Technical Data] Human Trials on Blood Sugar and Intestinal Health

We conduct various clinical trials for food products in response to promotional materials for health foods.

This document introduces human studies related to blood sugar and intestinal regulation for the application of health foods and specific health use foods. Our company conducts various clinical trials (human clinical trials) in response to health claims for the development application of Tokuhou (specific health use foods) and promotional materials for health foods. Experienced clinical trial managers carry out various tasks in the implementation of food clinical trials (human clinical trials) and provide high-quality data. [Contents] ■ Main Items ■ For Customers Like This ■ Blood Sugar Elevation Suppression Effect ■ Blood Sugar and Insulin Resistance Improvement Effect ■ Intestinal Regulation Effect *For more details, please refer to the PDF document or feel free to contact us.

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[Technical Data] Pharmacological Tests on Anti-Fatigue Effects

It is also possible to obtain congenic animals and conduct tests.

This document introduces "Pharmacological Tests on Anti-Fatigue Effects." Our company evaluates the anti-fatigue effects of pharmaceuticals and health foods using small animal models. In addition to the created disease model animals and naturally occurring disease model animals, it is also possible to obtain congenic animals for testing. [Contents] ■ Main Items ■ For Customers Like This ■ Forced Swim Test, Forced Running Test ■ Exercise Load Model Application Test for Obesity Models ■ Exercise Load Model Application Test for Summer Fatigue Models *For more details, please refer to the PDF document or feel free to contact us.

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[Technical Data] Human Trials on Lipids and Blood Pressure

We conduct various tasks in the implementation of food clinical trials and provide high-quality data.

This document introduces human trials related to lipids or blood pressure for the application of health foods and specific health use foods. Our company conducts various clinical trials (human clinical trials) in response to health claims for the development application of Tokuhou (specific health use foods) and promotional materials for health foods. Experienced clinical trial coordinators carry out various tasks in the implementation of food clinical trials (human clinical trials) and provide high-quality data. [Contents] ■ Main Items ■ For Customers Like This ■ Suppression of Triglyceride Increase ■ Cholesterol Lowering Effect ■ Blood Pressure Lowering Effect *For more details, please refer to the PDF document or feel free to contact us.

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[Information] List of Contracted Clinical Trials for Food Products

We accept contracts for various types of tests, starting from small-scale (small group) tests.

This document is a list of "Food Clinical Trial Contract Tests" conducted by Shin-Yaku Research Center Co., Ltd. Our company accepts various tests tailored to different purposes, from promotional tests to applications for Foods for Specified Health Uses (FOSHU). We accept contracts for various tests, starting from small-scale (limited number of participants) trials. Additionally, we welcome inquiries regarding various food clinical trials and consultations related to FOSHU applications, so please feel free to contact us. 【Test Contents (Partial)】 ■ Body fat reduction effect ■ Promotion of lipid excretion in feces ■ Suppression of postprandial triglyceride increase ■ Cholesterol reduction effect ■ Suppression of postprandial blood sugar increase, etc. *For more details, please refer to the PDF document or feel free to contact us.

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Technical Data: Pharmacological Tests on Wound Healing

We are evaluating the wound healing properties of pharmaceuticals and health foods using a small animal model.

This document introduces "Pharmacological Studies on Wound Healing." We will evaluate the wound healing properties of pharmaceuticals and health foods using small animal models. The models used include burn models, burn ulcer models, pressure ulcer models, incision models, damaged skin models, and abrasion models. [Contents] ■ Main Items ■ For Customers Like These ■ Rat Abrasion Model ■ Rat Pressure Ulcer Model *For more details, please refer to the PDF document or feel free to contact us.

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[Technical Data] Human Study on Body Fat Reduction

We accept contracts for various types of examinations, starting from small-scale (small group) tests.

This document introduces human trials related to body fat reduction for health food and specific health food applications. Our company employs experienced clinical trial coordinators who carry out various tasks in the implementation of food clinical trials (human clinical trials) and provide high-quality data. We accept contracts for various types of trials, ranging from small-scale (limited number of participants) studies. [Contents] ■ Main Items ■ For Customers Like This ■ Body Fat Reduction Effects ■ Promotion of Lipid Excretion in Feces *For more details, please refer to the PDF document or feel free to contact us.

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Technical Data: Pharmacological Tests on the Central Nervous System

We have achievements in step-through tests, Morris water maze tests, and brain gene analysis.

This document introduces "Pharmacological Tests Related to the Central Nervous System." Our company evaluates the effects of pharmaceuticals and health foods on brain function using both small and large animal models. We have extensive experience and a proven track record in evaluating various drug efficacies. For more details, please feel free to contact us. 【Contents】 ■ Main Items ■ For Customers Like This ■ Evaluation of Memory and Learning Ability in Aging-Accelerated Mice (SAMP8) ■ Analysis Using Microdialysis Method ■ Middle Cerebral Artery Occlusion (MCAO) Model in Mice and Monkeys ■ Chronic Pain Models in Rats and Monkeys ■ Evaluation Using MPTP-Induced Parkinson's Model *For more details, please refer to the PDF document or feel free to contact us.

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[Technical Data] Pharmacological Testing of Eye Drops

Leave the evaluation of pharmaceuticals and health foods related to eye health to us.

This document introduces "Pharmacological Testing of Eye Drops." Our company evaluates pharmaceuticals and health foods related to the eyes using small animal models. We have extensive experience and achievements in evaluating various pharmaceutical effects. Please feel free to contact us for more details. 【Contents】 ■ Main Items ■ For Customers Like This ■ Evaluation Using Ocular Inflammation Models ■ Evaluation Using Allergic Eye Disease Models ■ Effects on Intraocular Pressure ■ Evaluation Using Dry Eye-Induced Corneal Damage Models *For more details, please refer to the PDF document or feel free to contact us.

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Technical Data: Human Trials on Safety

We conduct various tasks in the implementation of food clinical trials and provide high-quality data.

This document introduces human trials related to safety for health foods and applications for specific health foods. Our company employs experienced clinical trial coordinators who carry out various tasks in the implementation of food clinical trials (human clinical trials) and provide high-quality data. We accept contracts for various types of trials, ranging from small-scale (few participants) studies. [Contents] ■ Main Items ■ For Customers Like This ■ Long-term Intake Safety Trials ■ Overconsumption Safety Trials *For more details, please refer to the PDF document or feel free to contact us.

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[Technical Document] Human Study II on QOL

We accept contracts for various types of examinations, starting from small-scale (small group) tests.

This document introduces human studies on the QOL improvement effects of health foods. Our company employs experienced clinical trial coordinators who carry out various tasks in the implementation of food clinical trials (human clinical trials) and provide high-quality data. We accept contracts for various types of studies, ranging from small-scale (few participants) trials. 【Contents】 ■ Main items ■ For customers like this ■ Bone metabolism improvement effects ■ Calcium absorption promotion effects ■ Improvement effects on cold sensitivity ■ Effects on exercise function *For more details, please refer to the PDF document or feel free to contact us.

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[Technical Document] Human Trial I on QOL

We conduct various tasks in the implementation of food clinical trials and provide high-quality data.

This document introduces human trials regarding the QOL improvement effects of health foods. Our company has experienced clinical trial coordinators who carry out various tasks in the implementation of food clinical trials (human clinical trials) and provide high-quality data. We accept contracts for various types of trials, ranging from small-scale (few participants) studies. [Contents] ■ Main items ■ For customers like this ■ Knee joint pain relief effects ■ Relief effects for menopausal disorder symptoms ■ Improvement effects for eye strain ■ Improvement effects for skin condition *For more details, please refer to the PDF document or feel free to contact us.

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Easy search from keywords - Disease-specific model list - [Free gift]

Reverse lookup from keywords possible! We offer a free NDRC disease model list that clearly shows animal models and keywords corresponding to disease names!

"I want to experiment on XX, but I don't know the disease name." "I want to research XX, but I don't know the corresponding animal model." "If only I could reverse lookup from keywords..." Are you facing such difficulties? With the 'NDRC Disease Model List,' we can solve these problems in one go. This book was created based on feedback from pharmaceutical companies. Please take a look. 【Contents (partial)】 <Disease Name> <Animal Model> <Keywords> Obesity Naturally occurring obese monkeys Dietary obesity Wound Rat incision model Incision Nephropathy Rat 5/6 nephrectomy model Chronic nephropathy etc. *For more details, please download the PDF or contact us. *For more details, please refer to the PDF document or feel free to contact us.

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[Data] Pharmaceutical Report

Publication on pharmacological tests of the central nervous system, including microdialysis.

This document is the Pharmaceutical Report published by the New Drug Research Center. It includes pharmacological tests on the central nervous system, as well as pharmacokinetic analyses using monkeys. [Contents] ■ Pharmacological tests on the central nervous system ■ Microdialysis ■ Chronic pain models (arthritis) ■ Rat pressure ulcer models ■ Evaluation of bladder function in monkeys ■ Pharmacokinetic analyses using monkeys ■ Efficacy evaluation using transgenic mice *For more details, please refer to the PDF document or feel free to contact us.

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[Data] Clinical trials targeting food products

Publication of examination results and features of NDRC/food clinical trials.

This document presents clinical trials focused on food conducted by the New Drug Research Center. It includes an overview of trial results, as well as explanations regarding NDRC and animal-to-human studies. Our company can provide proposals that include obtaining safety information necessary for clinical trials and examining the mechanisms of action of the involved ingredients. [Contents] ■Trial Results (Clinical Trials Focused on Food) ■NDRC / Features of Food Clinical Trials ■NDRC / Animal-to-Human Studies *For more details, please refer to the PDF document or feel free to contact us.

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[Data] List of Contracted Safety Tests

Publication of a list of contract tests for safety testing, such as reproductive and developmental toxicity tests.

This document lists the contracted safety tests published by the New Drug Research Center. Our company conducts general toxicity tests, reproductive and developmental toxicity tests, skin sensitization tests, phototoxicity tests, and antigenicity tests in compliance with pharmaceutical GLP. We also accept various safety tests for chemical substances and provide assistance in writing papers. [Contents] ■ Safety Tests ■ Testing services for mice/rats (blood, tissue tests) ■ Blood biochemistry tests ■ Pathological histological tests (sample preparation, observation, photography, electron microscopy) ■ Observation using electron microscopy ■ Compliance status with GLP, etc. *For more details, please refer to the PDF document or feel free to contact us.

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[Information] List of Contracted Clinical Trials for Food Products

Listing of contract tests for food clinical trials, including efficacy tests for health foods.

This document lists the contracted clinical trials for food conducted by the New Drug Research Center. Our company conducts various clinical trials (human clinical trials) related to health claims in applications for specific health foods (Tokubetsu Hokenyō Shokuhin) and promotional materials for health foods. [Contents] ■ Clinical Trials for Food ■ Introduction of Partner Medical Institutions (example) *For more details, please refer to the PDF document or feel free to contact us.

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Clinical trials related to clothing, food, and housing are possible! Contract research organizations that are not just for pharmaceuticals!

Support for pharmaceutical and food development, as well as clinical trials related to clothing, food, and housing, is possible! Safety and pharmacological tests using a wide range of animal species from small animals to large animals!

The New Drug Research Center is a contract research organization that supports the development of pharmaceuticals and food products. We conduct safety and pharmacological tests using a wide range of animal species, from small animals to large animals, at our two locations: the Central Research Institute and the Kobe Research Institute. Additionally, we carry out clinical trials in collaboration with multiple medical institutions. We provide comprehensive support from non-clinical trials to clinical trials, contributing to the development of a healthy and prosperous society. 【Business Activities (Partial)】 ■ Contracted pharmaceutical development ■ Contracted testing and analysis ■ Contracted medical device development ■ Clinical trials related to food, clothing, and housing, etc. *For more details, please download the PDF or contact us.

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Disease-specific model list for the pharmaceutical and food industries [Free gift]

Animal models and keywords corresponding to disease names are easily identifiable at a glance! Even if you don't know the specific disease name, you can uncover animal models and disease names from the keywords!

"I want to conduct experiments on XX, but I don't know the disease name." "I want to research XX, but I don't know the corresponding animal model." "If only I could reverse-search from keywords..." Are you facing such issues? With the 'NDRC Disease Model List', we can solve these problems in one go. This document was created based on feedback from pharmaceutical companies. Please take a look. [Contents (partial)] <Disease Name> <Animal Model> <Keyword> Obesity Naturally occurring obese monkeys Dietary obesity Wound Rat incision model Incision Nephropathy Rat 5/6 nephrectomy failure model Chronic nephropathy and so on *For more details, please download the PDF or contact us.

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Ames test using bacteria for revertant mutation testing

Test for detecting genetic mutations

Our company conducts tests to detect the mutagenicity of chemical substances using bacteria. We expose histidine-requiring Salmonella typhimurium and tryptophan-requiring Escherichia coli to several dose levels (usually more than five). Typically, experiments are conducted under two conditions: in the presence and absence of an exogenous metabolic activation system (S9 mix). A positive result is determined when the number of revertant mutation colonies increases by more than twice compared to the negative control group, and a dose-dependent response is observed. 【Features】 ■ Detection of mutations caused by base substitution or frameshift through the use of several types of bacteria ■ Can be conducted inexpensively and within a short period ■ Required for various application documents *For more details, please download the PDF or feel free to contact us.

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[Contracted Testing] Pathological Diagnosis and Cytodiagnosis

We conduct "molecular pathology diagnosis" using an automated image analysis device to provide data with excellent objectivity and reproducibility!

This is an introduction to the contracted tests for "Pathological Diagnosis and Cytology" that our company conducts. In "Molecular Pathological Diagnosis," it can be used for determining treatment eligibility, allowing for accurate tissue and cytological diagnoses, as well as testing for the expression of specific proteins using immunohistochemistry. In addition, we also offer high-quality and speedy diagnostics such as "Cytological Examination" and "Pathological Tissue Examination." 【Features】 <Molecular Pathological Diagnosis> ■ Usable for determining treatment eligibility ■ Identification of proteins and genes on pathological tissue sections ■ In addition to accurate tissue and cytological diagnoses, testing for the expression of specific proteins using immunohistochemistry is possible ■ Provides objective and reproducible analysis results by counting dozens to thousands of cells using an automatic image analysis system *For more details, please refer to the PDF materials or feel free to contact us.

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Pathological research outsourcing

We accept various pathological research contracts, such as "preparation of pathological specimens" and "cancer immunology-related analyses" for clinical samples and experimental animals!

This is an introduction to our "Pathology Research Contract Services." We offer services such as "Pathology Specimen Preparation," where we create various pathology specimens using samples you provide, including tissues, cells, and FFPE, as well as "Tissue Microarray Preparation," which involves embedding multiple tissues into a single block. In addition, we also conduct analyses related to "Cancer Immunology." Please feel free to contact us if you have any inquiries. 【Features】 <Pathology Specimen Preparation> ■ We create various pathology specimens using samples you provide, including tissues, cells, and FFPE. ■ Fluorescent single immunostaining and multiplex fluorescent staining are also possible. ■ Evaluation of immunostaining and other analyses can be performed using digital image analysis equipment. ■ Experienced clinical laboratory technicians carry out the work under the guidance of a full-time pathologist. *For more details, please refer to the PDF document or feel free to contact us.

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[Contract Testing] Glycan-related

We deliver complex structures such as glycan chains and glycopeptides from monosaccharide derivatives in high quality and high purity grades!

This is an introduction to our contract testing related to "glycans." "Glycan contract analysis" is a technology that significantly accelerates the comprehensive and quantitative profiling of glycans derived from biological samples based on chemically selective glycan capture reactions. With this technology, it is possible to extract and quantitatively analyze only the glycans from biological samples containing a large amount of contaminants such as DNA. In addition, we also offer "glycan contract synthesis." Please contact us if you require our services. 【Features】 <Glycan Contract Analysis> ■ Rapid glycan analysis is possible ■ A technology that significantly accelerates the comprehensive and quantitative profiling of glycans derived from biological samples based on chemically selective glycan capture reactions ■ It is possible to extract and quantitatively analyze only the glycans from biological samples containing a large amount of contaminants such as peptides, lipids, proteins, and DNA *For more details, please refer to the PDF document or feel free to contact us.

  • Custom reactions and synthesis

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Contract Testing: Protein

For those seeking high affinity and high specificity antibodies! Introducing contract testing services such as "GANP monoclonal antibody production."

This is an introduction to the contract testing of "proteins" that our company conducts. In addition to the standard pancreatic method, we also offer "GANP monoclonal antibody production," which can be carried out in a short period using the intestinal lymph node method, as well as "Luminex analysis" and more. Additionally, we provide sales of antibody products and perform antibody purification and labeling for the antibodies we produce or those you require. 【Features】 <Luminex Analysis> ■ Quantification of multiple biomarkers with just a few tens of μL of sample ■ Analysis possible with samples such as serum, plasma, and cell culture supernatant ■ Selection of measurement kits tailored to research purposes ■ Compatible with various species including humans, mice, and rats *For more details, please refer to the PDF document or feel free to contact us.

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Contract Testing: Genetic Analysis Related

Not only in the exon region but also in the junction part, probe design! This is an introduction to gene analysis-related topics!

This is an introduction to the contract testing related to "genetic analysis" that our company conducts. We offer a lineup including "GeneChip Transcriptome Array analysis," which can analyze all coding and non-coding transcripts, and the "GeneChip Gene1.0/2.0 ST Array analysis," which provides overwhelming cost performance. Please contact us if you have any inquiries. 【Features】 < GeneChip Transcriptome Array Analysis > ■ Probes designed not only for exon regions but also for junction areas ■ Capable of analyzing all coding and non-coding transcripts ■ Covers over 285,000 full-length transcripts ■ Visual and easy-to-understand analysis using Transcriptome Analysis Console (TAC) Software *For more details, please refer to the PDF document or feel free to contact us.

  • Other Analysis

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Contract for the production of genetically modified mice.

Analysis of lethal genes is possible! We also accept the production of mice using targeting vectors from KOMP and EUCOMM.

This is an introduction to our "Contract Services for the Production of Genetically Modified Mice." We offer services such as "Conditional Knockout Mouse Production," which allows for the analysis of lethal genes, as well as "Knock-in Mouse Production" and "ROSA26 Knock-in Mouse Production." In addition, we provide services for the breeding, reproduction, and mass production of genetically modified mice. We can propose plans tailored to your needs, so please feel free to consult with us. 【Features】 <Conditional Knockout Mouse Production> ■ Contains loxP sequences, allowing for gene disruption through the expression of Cre recombinase ■ Enables analysis of lethal genes ■ Can specifically disrupt genes in certain tissues ■ Allows for temporally specific gene disruption ■ Capable of producing mice from targeting vectors such as KOMP and EUCOMM *For more details, please refer to the PDF document or feel free to contact us.

  • Other contract manufacturing

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