レナセラピューティクス List of Products and Services

At Renac Therapeutics, we handle "Pharmaceutical Pipeline NASH Therapeutics (Nucleic Acid Medicines)." Using our proprietary technology, Hetero Double-Stranded Nucleic Acid (HDO) technology, we have discovered compounds that inhibit the expression of the NASH-related gene IHH. These compounds are expected to improve the NAFLD activity score in NASH animal models by inhibiting IHH expression, paving the way for the development of a novel NASH therapeutic. [Features] - Effectively inhibits the expression of the NASH-related gene IHH. - Also suppresses the expression of fibrosis marker genes such as COL1A1, CTGF, and TIMP1, suggesting potential as a fibrosis treatment. *For more details, please refer to the PDF document or feel free to contact us.

• Fine chemicals (compounds, derivatives, catalysts, etc.)

Our company handles "Hetero Double-Stranded Nucleic Acid (HDO)," which can selectively deliver active strands to disease sites by binding ligands to carrier strands, thereby expecting high therapeutic efficacy. HDO has a double-stranded structure, making it inherently stable. It avoids chemical modifications to the active strand, which can reduce toxicity. 【Features】 ■ Selectively delivers active strands to disease sites, achieving high therapeutic efficacy ■ Avoids chemical modifications and reduces toxicity ■ Provides a structurally stable material, improving enzyme resistance in the bloodstream ■ Low likelihood of unexpected therapeutic effects ■ Allows for free selection of the position and number of ligands binding to the carrier strand ■ The HDO technology is licensed to Takeda Pharmaceutical Company Limited, Ionis Pharmaceuticals (USA), Nippon Shokubai Co., Ltd., and Nippon Gene Material Co., Ltd. ■ The HDO technology is covered by multiple registered patents, ensuring safe use. ■ Collaborative research using HDO technology for drug discovery can also be conducted with our company. *For more details, please download the PDF or contact us.

• Other Nucleic Acid/DNA Research