ITWジャパン List of News Articles

When measuring the flow rate of liquids or gases that are unsuitable for plastic due to high pressure or high temperature, our robust "glass tube variable area flow meter (rotameter)" allows for more accurate flow measurements. It offers a wider flow range and is suitable for various liquids and gases! 【Features】 ■ Glass tube variable area flow meter ・ Flow measurement technology with high durability, economy, and excellent operability ・ Capable of a wider flow range, suitable for various liquids and gases ■ Metal tube variable area flow meter ・ Durability and accuracy that withstands high pressure and harsh temperature environments 【Product Lineup】 ■ Glass tube variable area flow meter ・ Sho-Rate models 1350, 1355, 1358 ・ GT1600 series ■ Metal tube variable area flow meter ・ MT3750 series ・ MT3809 series ▼ For more details, visit https://www.brooksinstrument.com/ja-jp/products/variable-area-flow-meters

This is a glass tube area flow meter suitable for measuring flow rates from low to high, designed with a robust structure that ensures long-term stable performance for applications involving gases and liquids where visibility of the process fluid is necessary. We will explain this in a 1 minute and 31 seconds video. https://www.youtube.com/watch?v=BgZMdBY4kLM Contents of the recording: ■ Basic mechanism and applications ■ Features ■ Monitoring important flow conditions ■ Scale design (The easy-to-read scale design allows for accurate flow monitoring. It can be operated intuitively, requiring no training for use.)

GT1000, GT1300, and Full-View(R) model successors "A simple yet robust design created to meet accuracy requirements" This is a robust glass tube area flow meter suitable for measuring flow rates from low to high, designed to provide long-term stable performance in applications involving gases and liquids where visibility of process fluids is necessary. The accuracy range can be optionally selected from 1% to 10% of full-scale flow. It is ideal for applications such as managing purge flow, seal oil units, bearing lubricants, and cooling water management. Additionally, when updating our GT1000, GT1300, and Full-View(R) 1100 series (models 1110, 1114, 1140, 1144), you can choose from model codes as compatible successors. Applications: ■ Industrial processes ■ Pharmaceutical manufacturing ■ Oil and gas pumping and refining processes ■ Chemical manufacturing ■ Burner control ■ Water treatment and supply systems

"Maximizing the Best Performance" This is the industry's first fully pressure-insensitive type of pressure-based mass flow controller (P-MFC) specifically designed for advanced etching and deposition processes in semiconductor manufacturing. The GP200 series P-MFC adopts a patented architecture that overcomes the limitations of conventional P-MFCs, enabling high-precision process gas supply even with low vapor pressure process gases. It also features a built-in differential pressure sensor and a unique design that places the valve downstream, allowing for high-precision process gas supply across the widest range of operating conditions in the industry. Due to its compatibility with a wide range of process conditions, it can be used as a replacement or upgrade for conventional P-MFCs and thermal MFCs. Additionally, by eliminating the need for components such as pressure regulators and converters, it simplifies the gas supply system and reduces costs. [Main Applications] ■ Semiconductor Manufacturing ■ Etching ■ CVD ■ Gas flow control applications requiring high-purity all-metal flow paths

We explain the operating principle of the GP200 series metal seal type pressure-based mass flow meter (P-MFC) in a video. (English) https://www.youtube.com/watch?v=ZWB03A_9fo8 Video Chapters 00:00 - What is Brooks Instrument? 01:00 - What is a conventional pressure-based MFC? 02:10 - Introduction to the GP200 pressure-based MFC 03:30 - Advantages of the GP200 MFC 03:50 - Pressure measurement method of the GP200 MFC 04:45 - Superiority of the GP200 This pressure-based mass flow meter adopts a unique design that overcomes the limitations of conventional pressure-based MFCs and significantly improves process performance.

Model SLA5850/SLA5851/SLA5853/SLA5860/SLA5861/SLA5863 "With just one unit, you can use 14 types of pressure and flow rates in a single process." Imagine such a mass flow controller platform. Moreover, it features excellent reproducibility, precision, and repeatability. This is the evolved simple performance of the SLA5800 series mass flow controllers/meters. The SLA5800 series boasts high accuracy, zero point stability, and repeatability that are characteristic of Brooks Instrument, a leader in mass flow measurement and control technology. Equipped with configurable advanced multi-gas/multi-range capabilities, it offers superior zero drift specifications compared to competing products while demonstrating long-term maintenance of factory calibration and accuracy.

The operating principles of the SLA series are explained in the video. (English) https://www.youtube.com/watch?v=XKpX3rrt1qc Video Chapters 00:00 What is Brooks Instrument? 00:10 How to connect power to the thermal mass flow meter 00:24 Basic structure of the thermal mass flow meter 00:35 Diverting a portion of the gas flow with a laminar flow element 00:56 Measuring temperature difference with thermal sensors 01:08 Excellent sensor stability 01:37 How to measure process gas flow 02:17 Circuit board of the thermal mass flow meter 02:34 What are advanced alarm and diagnostic functions? <Main advantages of Coriolis flow meters> ■ Long-term stability of the sensor eliminates the need for maintenance or regular recalibration, reducing total ownership costs ■ Brooks Instrument's unique thermal sensor technology improves the S/N ratio and enhances flow accuracy at low set points.

Application notes from various markets showcase how Brooks Instrument's measurement and control technologies create competitiveness for original equipment manufacturers, pilot plants, production plants, laboratories, and universities. ■ Analyzer Market ■ Aerospace and Automotive ■ Chemical and Petrochemical ■ Food & Beverage ■ Life Sciences: Biotechnology, Pharmaceuticals, Medical Devices ■ Oil & Gas ■ Semiconductor Manufacturing ■ Thin Films, Coatings, and Surface Treatment ■ Water Treatment and Wastewater Treatment For more details, visit here: https://www.brooksinstrument.com/ja-jp/markets

Realizing Precision Control in Energy Innovation Hydrogen, fuel cells, CCUS, biofuels, CNT manufacturing. There are technologies on-site that monitor precise flows to support the energy of the future. Brooks Instrument's flow meters support the energy transition.

The operating principle adopted in the Quantim QMC Coriolis flow meter (3rd generation) is explained in a video. (English) https://www.youtube.com/watch?v=_BXWlSn3Q_I Video Chapters 00:00 About Brooks Instrument 00:16 Operating principle of the Coriolis mass flow meter 00:27 Law of conservation of momentum 00:40 Law of conservation of angular momentum 00:52 Basic structure of the Coriolis mass flow meter 01:07 How to power on 01:23 Sensor structure boasting high stability 01:40 Sensor tube vibrating at natural frequency 02:14 Phase difference detection of the sensor tube 02:59 Signal processing by electronic circuits 03:08 Method of measuring process flow 03:47 Role of the circuit board 03:58 What advanced alarm and diagnostic functions are 04:22 About calibration <Main advantages of the Coriolis flow meter> ■ Improves process quality, yield, and productivity ■ Reduces scale-up time from laboratory to pilot plant and then to manufacturing line ■ Reduces total cost of ownership (TCO)

The new Quantim QMC Coriolis flow meter (3rd generation) is ideal for applications involving the measurement and control of minute flows of gases and liquids. The Quantim® QMC Coriolis mass flow controllers and meters provide extremely accurate, stable, and reproducible measurements and control for minute flows of gases and liquids. This new 3rd generation Quantim QMC Coriolis mass flow controller and meter contributes to shortening the scale-up period from lab to pilot plant to production by enhancing process quality, production yield, and throughput. The new Quantim QMC Coriolis mass flow series is compatible in terms of mounting dimensions and functionality with the old models of Quantim from Brooks Instrument. Applications: ■ Catalyst research ■ Mass balance calculations in chemical pilot plants ■ Precursors supply to vaporization units ■ Precision coating ■ High-accuracy filling stations ■ Feedback/control loops for metering pumps ■ Vacuum processes ■ Semiconductor wafer processes

Model GF100 / GF101 / GF120 / GF120XSL / GF120XSD / GF121 / GF125 / GF126 "Achieving high purity and ultra-high purity process gas supply with excellent response speed and repeatability" The GF100 series, designed for semiconductor, MOCVD, and other gas flow control applications, ensures high repeatability and stable performance, providing reliability that exceeds industry standards. With standard MultiFlo(TM) technology, it supports thousands of combinations of gas types and ranges without disconnecting from the gas line or sacrificing accuracy. It achieves industry-leading gas cleanliness while enhancing process flexibility and efficiency, maximizing yield and productivity. Applications ■ Semiconductor etching tools ■ Thin film chemical vapor deposition (CVD) systems (CVD, MOCVD, PECVD, ALD) ■ Physical vapor deposition (PVD) systems ■ Epitaxial process systems

【New Product Information】 Coriolis Mass Flow Controller/ Meter 'QMC Series' GF120xHT Series Metal Seal Specification 'High-Temperature Mass Flow Controller' ★Please check the features in the 【Panel Materials】! We also offer online briefings. If you are interested, please feel free to contact us. https://www.brooksinstrument.com/ja-jp/about-us/contact

■ Wide flow range/pressure conditions and support for digital I/O ■ Certificates and certifications ■ Applications Please take a look here. https://www.ipros.jp/catalog/detail/752600 You can also view it from related catalogs.

Hot melt extrusion (HME) is a method that involves melting polymers by applying heat and pressure, and extruding them into molds in a continuous process. HME is widely used in the plastics industry and has recently been applied to pharmaceutical formulations and drug delivery systems. The HME process is used to mix active pharmaceutical ingredients (APIs) with polymers and other excipients at high temperatures and pressures. The extruded material can be cut or ground into micro-pellets for filling into capsules or compressing into tablets. ☆Application note now available☆ "Enhancing Drug Delivery Systems through High-Precision Measurement and Control of Supercritical CO2 Using Coriolis Mass Flow Meters" For more details, visit here https://www.brooksinstrument.com/ja-jp/blog/highly-reliable-accurate-coriolis-flow-meter-for-carbon-dioxide-injection [ITW Japan Co., Ltd. Brooks Instrument]

A world where miniaturization and high performance are progressing daily. Mobile phones now have features that were unimaginable just a few years ago. This high performance has been made possible thanks to thin film technology, which is utilized in a wide range of applications as listed below. 【Applications of Thin Film Technology】 - Microelectronics - Anti-reflective coatings for glass - Antibacterial metal coatings for medical devices - Flexible solar cells Thin film technology is defined as "the process of creating, coating, and processing thin film materials on a substrate surface." 【PVD and CVD Technologies】 - What is PVD? - What is CVD? - What is Thermal Filament CVD? - What is Plasma CVD? - CVD Process - Range of CVD Applications - Battery Market - Thin Film Technology Used in the Battery Market Please take a moment to read it. https://mono.ipros.com/news/detail/129945/

We will introduce a comparison of CVD and PVD, applications of flow meters and pressure gauges, and examples of digitalization in process control. In a world where miniaturization and high performance are advancing daily, mobile phones now have features that were unimaginable just a few years ago. The realization of such high performance is thanks to thin film technology, which is utilized in a wide range of applications such as the following: 【Applications of Thin Film Technology】 - Microelectronics - Anti-reflective coatings for glass - Antibacterial metal coatings for medical devices - Flexible solar cells Thin film technology is defined as "the process of creating, coating, and processing thin film materials on a substrate surface." We will provide explanations of thin film technology, comparisons of CVD and PVD, applications of flow meters and pressure gauges, and examples of digitalization in process control. We encourage you to read on. ★ We also offer foundational knowledge that delves deeper into the explanations of CVD and PVD, as well as basic knowledge materials related to glass coatings for the glass industry! https://mono.ipros.com/news/detail/128269/

Titanium is frequently used in such applications to form a very hard titanium nitride (TiN) coating on the target products. Titanium coatings are often used for decorative purposes on jewelry, household appliances, and automotive trim due to their golden appearance. Similar coatings may also be used on the surfaces of medical devices and instruments as non-toxic options. This type of coating is now being applied in advanced biomedical devices, including in vivo biosensors. The coating of titanium nitride generally employs the CVD process. In this process, multiple chemicals (TiCl4, N2, H2) are supplied to a furnace and reacted at high temperatures to produce titanium nitride, which is then deposited on the surface as a coating. It is crucial for the integrity, appropriate thickness, and uniformity of the coating to accurately deliver these materials to the furnace.

The Pirani vacuum gauge "VersaTorr Series" features the BVT100 series with a dual sensor system combining diaphragm and MEMS Pirani types, and the BVT200 series with a triple sensor that integrates a capacitance manometer for wider range measurements. The newly developed MEMS Pirani sensor enables wide-range measurements down to 7.5 x 10E-7 Torr, which is one order of magnitude lower than typical MEMS Pirani sensors. By covering the high-pressure range of 1.5 to 1000 Torr, where the Pirani sensor is affected by gas thermal losses, with a diaphragm type, it allows for wide-range measurements from 7.5 x 10E-7 to 1000 Torr. For more detailed information, please visit the following website (English version): https://www.brooksinstrument.com/en/products/pressure-vacuum/pirani-transducers

"MFC equipped with PTI (Pressure Variation Resistance)" The 'GF125 series,' featuring ultra-fast response and high cleanliness, is a metal-sealed mass flow controller equipped with second-generation PTI (Pressure Variation Resistance). It significantly reduces the impact of inlet pressure fluctuations on process gas flow rates. The MultiFlo technology, standard in the GF125, allows for thousands of combinations of gas types and ranges without disconnecting the flow meter from the gas line or compromising accuracy. This feature contributes to reducing the size and cost of gas panels by reviewing pressure regulators, pressure transducers, and related hardware installed in the process line, alongside industry-leading PTI performance that maximizes yield and productivity. Applications: ■ Semiconductor etching tools ■ MOCVD ■ Gas flow control applications requiring high-purity all-metal flow paths

The Brooks Expert Support Tool 'BEST (Brooks Enhanced Support Tool)' is a Windows-based application software designed to control high-performance mass flow controllers, meters, and pressure controllers specifically for the SLA58XX and SLAMfXX series. By using this tool, you can utilize functions including setup, configuration, diagnostics, troubleshooting, valve adjustment, and calibration (a separate license key is required). You can access the diagnostic port located at the top of the device by connecting it to your computer with a dedicated cable. For specifications, licensing requirements, and operation methods, please contact us. Please check the following page for compatible products: https://www.brooksinstrument.com/ja-jp/products/accessories-software/product-software/brooks-expert-support-tool ■ Currently available versions V5.14.1.0 V5.12.0.0 V5.10.0.0

The 0250 series is a secondary electronics unit equipped with an RS232 serial port, in addition to power supply and analog control functions. This innovative and reliable microcomputer-based controller is available in two models. 【Model 0251】 Supplies power to one Brooks mass flow or pressure device. 【Model 0254】 Supplies power to up to four Brooks mass flow or pressure devices. This device, compliant with the RoHS directive, features very user-friendly operability and offers mounting options for easy installation in a variety of applications.

Model GF40 "One device supports various gases and flow rates" The ability to accommodate multiple gases with a single device maximizes process flexibility and productivity. The GF40 series elastomer-sealed mass flow controllers/meters, equipped with Brooks Instrument's proprietary MultiFlo technology, are ideal for systems, processes, and facilities that use diverse gases, frequently change gas types, or need to recalibrate ranges while maintaining measurement and control accuracy. With unprecedented flow measurement and control performance, it elevates process flexibility to a new dimension. Applications ■ Solar cell CVD (Chemical Vapor Deposition) systems ■ Life science bioreactors ■ Vacuum processes ■ Nanotechnology/MEMS manufacturing ■ Plasma, glass, web coating systems ■ Options for manifold/gas supply systems

- I want to hear the product explanation, but there is not enough information through email or phone. - It is difficult to find time for a meeting. By conducting the product explanation in a video conference format, we believe that you will be able to understand our products more deeply while sharing materials with you, almost like an in-person meeting. Please feel free to take advantage of our online product explanation service. <Flow of Online Product Explanation> ▼ STEP 1 | Application ▼ STEP 2 | Application Acceptance We will send you an email from our representative with the date and time for the online product explanation and the link for the video conference. ▼ STEP 3 | Online Product Explanation On the day of the meeting, access the link provided in the email to start the video conference. We will use Microsoft Teams for the video conference. Installation of the software is not required, but please feel free to consult us if you have any other service requests.

Surfaces of industrial and consumer products may be coated to optimize their finish. For example, it is possible to improve the wear resistance of cutting tools, scratch resistance of glass, thermal properties of sheet glass, and aesthetics of household appliances. There are various coating methods such as chemical vapor deposition, physical vapor deposition, plasma treatment processes, and thermal spraying, but they are often performed as the final stage of the manufacturing process. Brooks Instrument's mass flow, vacuum, and pressure measurement and control devices cover PVD and CVD process applications. They are also suitable for surface treatment applications such as heat treatment and plasma processing. 【Features】 ■ Highly reproducible, high-precision gas supply ■ Excellent quality, accurate thickness, uniformity of film thickness ■ Long-term stable process control ■ High-functionality flow diagnostics and trend analysis in the field to maximize process yield

"Achieving the highest flow accuracy in ultra-high purity DI steam supply" The Vapor Delivery Module (VDM) features an energy-efficient design that generates ultra-high purity vaporized gas even at low temperatures. It employs proven steam delivery technology and is equipped with advanced digital control and comprehensive diagnostic functions. Compared to flash vaporization systems, it achieves superior accuracy, high flow rates, a wide control range, and low power consumption. Based on proven thermal mass flow measurement technology, it generates steam even in non-heated conditions, eliminating the influence of pure water, thus ensuring high reliability and high purity manufacturing. An independent service port and intuitive GUI provide user-friendly data logging and diagnostic capabilities. Applications: ■ Post-process for metal etching of silicon semiconductors ■ Metal strip process for silicon semiconductors ■ Ultra-high purity humidification in low atmospheric pressure environments For more details, please visit https://www.brooksinstrument.com/ja-jp/products/vaporization/vapor-delivery-modules/vdm300

■ Mass Flow Controller/ Meter "GF40 Series" This device supports multiple gases, maximizing process flexibility and productivity. The GF40 series elastomer-sealed mass flow controller/meter, equipped with Brooks Instrument's unique MultiFlo technology, is ideal for systems, processes, and facilities that use diverse gases, frequently change gas types, or need to readjust ranges while maintaining measurement and control accuracy. It offers unprecedented flow measurement and control performance, elevating process flexibility to a new dimension. ■ Readout Unit "0254" *RoHS Compliant Product* The 0250 series is a secondary electronics unit equipped with an RS232 serial port, in addition to power supply and analog control functions. This RoHS-compliant device features very user-friendly operability and offers installation options to easily fit into various application environments. It provides power for up to four Brooks mass flow or pressure devices.

How can digital mass flow controllers and Ethernet-based network protocols improve your production processes? <Solving process challenges with abundant data from measuring instruments> - Evolution of digital communication - Types of digital communication protocols - Benefits of "digitalization" - How digital protocols enhance the added value of equipment - Digital applications: Flow integration in gas usage monitoring - Digital applications: Flow integration measurement in bioreactors - Considerations when selecting digital communication protocols - Expanding the portfolio of digital devices

Model 3809G / 3809G ELF / 3809G TFE Lined / 3810G "Proven meters that accommodate a wide range of temperatures, pressures, and processes" With a structure that can be installed in harsh environments, both indoors and outdoors: For high-pressure conditions, low or high-temperature fluids, and remote monitoring applications, please consider the "MT3809 Series Metal Tube Area Flow Meter." The MT3809 Series boasts a wealth of experience in the reliable and repeatable measurement of gas and liquid flow, making it a key product for equipment selection in engineering companies (EPC) and large plants worldwide. Applications ■ Basic measurement of liquid or gas flow ■ Monitoring lubricants and cooling water for rotating equipment ■ Measurement of additives ■ Monitoring gas for smelting furnaces (kilns) ■ High-pressure flow on offshore oil platforms ■ Chemical injection

We have over 70 years of global experience in more than 80 countries! When project design, procurement, and construction (EPC) contractors require high-performance flow meter technology and advanced technical expertise, we become a reliable supplier for accurate solutions. Our products are adopted in various application fields, from nuclear and biotechnology to power and petrochemicals, which is why we have over 70 years of global experience in more than 80 countries. The performance and value of our products prove this, and we provide suitable support to EPC partners for each project. 【Features】 <MT3809 Series Metal Tube Area Flow Meter> ■ Robust design that accommodates high process pressures ■ Alarm function complies with SIL 2 requirements ■ Multiple corrosion-resistant wetted materials and indicator housings available ■ Complies with ASME B31.3 standards

In industries such as biotechnology, certification is used to ensure the calibration accuracy of flow control. Equipment that measures and controls fluid flow must be calibrated at the time of initial manufacture and then regularly recalibrated to guarantee accurate measurement and control. For measurement instrument manufacturers like Brooks Instrument, the calibration of flow measurement and control equipment using high-precision measurement systems is essential. In fact, the tightening of regulations in industries such as biotechnology places even greater demands on measurement instrument manufacturers to document known uncertainties through certification. For example, in biotechnology process systems, mass flow controllers (MFCs) control the supply of process gases such as oxygen and carbon dioxide to bioreactors. Accurately and consistently supplying these gases is one of the factors that process managers seek to verify and manage in order to maximize the yield, performance, and uptime of the bioreactor.

The research example of catalysts discussed here is the Haber-Bosch process, which produces ammonia for fertilizers on an industrial scale. The Haber-Bosch process involves reacting nitrogen and hydrogen using a metal catalyst under high temperature and pressure to produce ammonia. Research on catalysts is constantly advancing, and various catalysts have been discovered today. Initially, osmium was used as the catalyst in the Haber-Bosch process, but now iron ore is used as the catalyst. Catalyst research is conducted in pilot plants. Pilot plants provide valuable early-stage scientific data regarding reactions, material properties, and process yields, thereby reducing the technical and commercial risks associated with large-scale process plants. In this research, experiments are conducted while monitoring all parameters, including pressure, temperature, flow rate, and reaction time.

Model SLAMf50 / SLAMf51 / SLAMf53 / SLAMf60 / SLAMf61 / SLAMf63 / SLAMf64 "Durability to withstand harsh environments! Achieving excellent precision with precise mass flow control" Whether indoors or outdoors, in environments with dust or places that handle water, the 'SLAMf series' elastomer seal thermal mass flow controllers/meters provide proven high precision and long-term stability unique to the "SLA5800 family." Applications ■ Pilot plants for petrochemical and chemical gases ■ Life science bioreactors ■ Blanketing in food processing

The GP200 series is the first fully pressure-independent PMFC designed specifically for semiconductor applications. With GP200's unique differential pressure technology and state-of-the-art sensor and valve configuration, it eliminates the limitations of traditional pressure-based mass flow controllers, enabling the most extensive and accurate process gas control in the industry. Brooks developed the world's first MFC that allows for the reconfiguration of gas types and flow ranges, and has continued to refresh gas models since its release, with the same functionality incorporated into the GP200. It allows for easy reconfiguration for many gas types and a wide range of flow rates, providing flexible support for a variety of processes. The ultra-fast and highly reproducible valve control of the GP200, along with its resistance to pressure fluctuations, maintains precise flow control to the chamber even in cases of extreme supply pressure variations, enabling tighter process control. The GP200 platform supports a wide range of process conditions and can replace or upgrade many traditional pressure-based mass flow controllers.

<Published Content> Mass Flow Controllers / Mass Flow Meters Pressure Controllers Area Flow Meters Pressure and Vacuum Products Secondary Electronics & Software Communication Protocols Service & Support This is a product guide that summarizes the main features and performance in an easy-to-read format. Please make use of it.

A world where miniaturization and high performance are advancing daily. Mobile phones now have features that were unimaginable just a few years ago. The realization of such high performance is thanks to thin film technology, which is utilized in a wide range of applications as follows: 【Applications of Thin Film Technology】 - Microelectronics - Anti-reflective coatings for glass - Antibacterial metal coatings for medical devices - Flexible solar cells Thin film technology is defined as "the process of creating, coating, and processing thin film materials on a substrate surface." We are currently publishing basic knowledge materials on glass coatings for the glass industry! ⚫ Glass Coatings ⚫ What is Low-E Glass? ⚫ Laminating and Materials of Low-E Coatings ⚫ Application Requirements ⚫ What is Low-E Coating Technology? ⚫ Glass Coating Market Please take a moment to read it. https://mono.ipros.com/news/detail/129167/

Brooks has added a mass flow controller specifically designed for bioprocesses to its range of general-purpose mass flow controllers. In this article, we will introduce this product and its distinctive advantages. 1. One MFC can cover the necessary spare parts for each type of gas. 2. With a control range of 1:250, it enables high-precision and accurate flow control, reducing the number of MFCs needed. 3. It accommodates a wide range of bioreactor needs, from benchtop types to large stainless steel tanks. There is a wealth of adoption experience for both single-use and multi-use applications. For more detailed product specifications, case studies, and advantages, please feel free to contact us. A representative well-versed in flow control and bioreactors will assist you.

Hot Melt Extrusion (HME) is a method that uses heat and pressure to melt polymers and extrude them into molds in a continuous process. HME is widely applied in the plastics industry and has recently been used in pharmaceutical formulations and drug delivery systems. The HME process is used to mix active pharmaceutical ingredients (APIs) with polymers and other excipients at high temperatures and pressures. The extruded material can be cut or crushed into micro-pellets for filling into capsules or compressing into tablets. Highlights: Measurement and control of mass flow rate of supercritical CO2 Achieving accurate flow rates even at low temperatures (below -30°C) Process Solution: Due to the high reliability of Brooks Instrument's Quantim Coriolis mass flow measurement and control for fluids, systems using this mass flow can measure and control the mass flow rate of the liquid CO2 being injected, rather than the pump's operating speed. In the HME process, when CO2 is maintained above its critical temperature and critical pressure, it enters a supercritical state.

Low-emissivity (Low-E) coated architectural glass has become one of the most popular functional building materials. It plays a crucial role in improving the energy efficiency and energy-saving properties of buildings by minimizing heat loss and internal condensation. The coating (thin film) applied to the glass controls the flow of visible light energy passing through the glass. This coating alters the characteristics of light transmission, reflection, and absorption in different parts of the electromagnetic spectrum, such as infrared, visible light, and ultraviolet. When viewed from inside the building, Low-E glass reflects energy back into the building, achieving significantly lower heat loss compared to regular glass. When viewed from outside the building, Low-E glass allows the visible portion of solar energy to pass through while minimizing the infrared portion, thereby reducing heat loss from the building.

In the EtherNer/IP model, when scaling up a system built at a desktop research lab level to manufacturing level, it is relatively easy to implement specification changes from single control to recipe control. The SLA5800 series is available in a flow range from 3cc/min to a maximum of 2500L/min, allowing for scaling up by adjusting parameters to match the maximum capacity using recipes and interfaces. When replacing or adding MFCs in the evaluation system, it can be done simply with just a LAN cable and a power cable, without the need for additional hardware. This not only contributes to flexible system changes but also significantly improves space efficiency and maintainability. At the same time, IoT integration is also possible. Remote operation can be incorporated on a PC basis with a low barrier to implementation. The SLA5800 series bio package uses FDA-compliant elastomers. It is capable of providing documentation and evidence, while also increasing the shielding rate during valve closure compared to conventional products, enabling more precise adjustments of dissolved oxygen (DO) levels, particularly in oxygen control. ITW Japan Co., Ltd. Brooks Instrument

In the manufacturing process of active pharmaceutical ingredients for biopharmaceuticals, including antibody drugs and vaccines, the goal is to culture and scale up biological entities such as viruses and cells, necessitating the creation of an environment conducive to the survival of the target organisms. The research and development department continuously seeks the optimal conditions for each type of cell or virus, which involves adjusting the flow rates of air, oxygen, nitrogen, and carbon dioxide to achieve optimal concentrations. Additionally, it is crucial to maintain a stable environment by adjusting the flow rates of each gas in response to monitoring results of pH and dissolved oxygen concentration. Particularly for oxygen, even small flow rates can lead to a rapid increase in dissolved oxygen concentration, requiring precise control of the flow rates. The SLA5800 series has a proven track record in many culture devices and facilities, continuing from the previous generation 5800E/i series, and is a stable product line with a large number of units shipped and consistent maintenance continuity. ITW Japan Co., Ltd. Brooks Instrument

The importance of gas flow control and mass flow controllers in the manufacturing of biopharmaceuticals, including antibody drugs, has been frequently introduced. This time, we will introduce the applications of mass flow controllers/flow meters in medical devices. In the manufacturing and control of respiratory-related medical devices, flow meters and mass flow controllers are utilized. The key factor is to maintain the appropriate ratio of oxygen and carbon dioxide concentrations in the respiratory gas, optimizing blood concentrations. It is necessary to precisely adjust and supply the gas flow of air/oxygen. The requirements include the ability to adjust gas flow to maintain appropriate concentrations in the respiratory gas and the functionality to mix/blend. Additionally, it is important to ensure that appropriate materials are used for medical devices/equipment. For gas blending applications, we offer a range of products including area flow meters (including those with valves), the SLA5850 series mass flow controllers, and the SLA5850 Biotech package, which comes pre-installed with the required four types of gas calibration data and uses materials compliant with USP standards. ITW Japan Co., Ltd. Brooks Instrument

The VDM300, designed for advanced stripping and passivation processes after metal etching, achieves superior accuracy, high flow rates, a wide control range, and low power consumption compared to flash vaporization systems. Features of the VDM300: 1. Flow range: 3 slpm (DIW vapor) 2. Direct steam measurement for excellent flow accuracy 3. Direct connection to the plant's pure water supply system 4. Operable even at minimum temperature (non-heated state) 5. Optimally designed for rinsing and drainage 6. EtherCAT digital communication 7. Brooks Expert Support Tool (BEST) graphical interface

Many people may have questions like, "What can be done with IoT?" and "What is needed?" upon hearing the term IoT. Through digital communication, it is possible to obtain various information such as flow sensors, valves, circuit boards, and abnormal monitoring that were not accessible with traditional analog control. For example, by monitoring the valve opening, one can detect blockages in the equipment and identify leaks from cumulative flow. This information directly contributes to reducing downtime and improving quality through continuous long-term monitoring and knowledge-based management. Compatible models include those with digital communication via RS485, in addition to traditional analog controls like 0-5VDC and 4-20mA. (Older models such as the 58xxS, MfxxS series, SLA58xxS, and SLAMfxxS series). Even older models that do not support digital communication can be upgraded to the latest mass flow models, enabling digital communication. The dimensions between new and old models are the same, and no wiring changes are necessary. Additionally, we can provide control boxes for data collection from mass flow. This enables a "visualization" of small IoT without making large changes to the equipment.

When using a thermal mass flow meter, it is very important to understand its measurement principle. Setting high-precision and stable process conditions is not only essential but also very beneficial for troubleshooting and early detection. The sensor consists of a heater (H) placed in the center of the tube and temperature sensors (T1 and T2) positioned equidistantly on either side. The heater is continuously supplied with properly controlled power, generating heat. When there is no flow in the sensor tube, the heat from the heater is evenly transferred to temperature sensors T1 and T2, resulting in both being at the same temperature. However, when there is flow in the direction indicated by the arrows in the diagram, the fluid carries heat away from T1, causing its temperature to drop, while T2 receives heat, resulting in a temperature increase. The resulting temperature difference between T1 and T2 becomes a function of the mass flow rate of the fluid within the sensor tube. This is processed appropriately and output as an electrical signal representing the mass flow rate. (This is an excerpt from the original text.) https://www.youtube.com/watch?v=XKpX3rrt1qc [ITW Japan Co., Ltd. Brooks Instrument]