アンチエイジング Product Lineup

Do you have any of these concerns? - I want to meet consumer needs for the functionality of exosomes. - I want to clearly promote "exosomes" in the full ingredient list of cosmetics. RS Mixture 9.6E solves these issues. 【Feature 1】Ability to promote exosomes in the ingredient list Human stem cell culture fluid naturally contains exosomes, but they cannot usually be listed as an ingredient. This product allows for the addition of exosomes manufactured in a separate line, enabling the labeling of "human adipose-derived mesenchymal stem cell exosomes." 【Feature 2】Significant increase in exosome content By adding 1% concentrated exosomes, the number of exosome particles measured by nano-tracking analysis has increased by approximately 1.4 times. 【Feature 3】Diverse beauty effects High beauty effects are expected, including anti-aging effects on aging cells, reverse aging effects, and promotion of collagen and hyaluronic acid biosynthesis. *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

Do you have any of these concerns? - I want to incorporate NMN into cosmetics, but I'm struggling because it is not absorbed through the skin. - I am looking for ingredients with higher anti-aging effects against aging cells. "RS Liposome 3.0E NMN" will solve these issues. 【Feature 1】 Synergistic effect of human stem cell culture fluid and NMN NMN improves aging by turning on the genetic switch, while exosomes improve cellular aging by turning off the genetic switch. By combining these two, a synergistic effect that improves aging is expected. 【Feature 2】 Enhanced permeability NMN derivative Regular NMN is not absorbed through the skin and shows almost no permeability after 24 hours, but the permeable NMN derivative "Pentide-NMN" is processed to penetrate the skin. 【Feature 3】 Reverse aging effect through exosomes Exosomes secreted under RemyStem's culture conditions have been confirmed to rejuvenate fibroblasts that have aged due to UV exposure. *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

Do you have any of these concerns? - Looking for a combination of ingredients to enhance the effects of stem cell culture fluid - Wanting raw materials that have a strong synergistic effect on collagen production and skin whitening "RS Liposome 3.0 Complex" solves these issues. 【Feature 1】Synergistic effect of human stem cell culture fluid and vitamin C Vitamin C is necessary for cells to execute the information received from stem cells and to promote collagen polymerization. By formulating these two together, a synergistic effect can be expected, strongly promoting collagen production. 【Feature 2】Double penetration technology with different mechanisms To enhance penetration, we use liposome-processed human stem cell culture fluid and a derivative that delivers vitamin C using cell-permeable peptides, employing completely different approaches to ensure functional materials penetrate to the cells. *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

Do you have any of these concerns? - Looking for ingredients that help the skin produce beauty components like collagen and hyaluronic acid - Wanting to promote skin turnover and engage in anti-aging Remy Stem solves these issues. 【Feature 1】 The power of active substances produced by stem cells Stem cells, which are attracting attention in regenerative medicine, can send active substances to other cells. By receiving these substances, beauty components such as collagen and hyaluronic acid are produced. 【Feature 2】 New information transmission through exosomes In addition to traditional paracrine factors, we use exosomes, which are vesicles used for information transmission between cells, as cosmetic ingredients. 【Feature 3】 Contains diverse growth factors It includes a variety of growth factors such as EGF (epidermal growth factor) and FGF (fibroblast growth factor). *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

Do you have any of these concerns? - Looking for ingredients to revitalize cells that have decreased in activity due to aging. - Wanting to promote the production of collagen and hyaluronic acid to improve wrinkles and enhance skin beauty. RemyStem solves these issues. 【Feature 1】Reverse aging effect on aged fibroblasts When added to fibroblasts that have stopped dividing due to photoaging from UV rays and are secreting SA-β-galactosidase, the SA-β-galactosidase decreases and cell division begins. It has been confirmed that this ingredient that improves aging is a stem cell exosome. 【Feature 2】Promotion of collagen and hyaluronic acid biosynthesis In fibroblasts, the production of collagen (Type I) and hyaluronic acid, which are major components of skin tissue, is increased in a concentration-dependent manner. This is expected to lead to effects such as wrinkle improvement and anti-aging. *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

Do you have any of these concerns? - I want to ensure that the components of stem cell culture fluid are delivered to the necessary cells. - I am looking for cosmetic ingredients that have a high in vivo utilization rate and act effectively in small amounts over a long period. RemyEV-3 solves these issues. 【Feature 1】Fusion of Exosomes and Liposomes Both exosomes and human stem cell culture fluid liposomes have membranes made of phospholipids, resulting in hybrid exosomes formed by their fusion. This creates particles of approximately 100nm. 【Feature 2】Dramatic Improvement in In Vivo Utilization Rate Thanks to the functions of antigens on the surface of exosomes, immune cell attacks are suppressed, allowing them to exist longer in the body. This significantly enhances the biocompatibility and in vivo utilization rate of the bioactive substances in human stem cell culture fluid. 【Feature 3】Reliable Permeability to the Dermis Fluorescent imaging analysis using FCM tissue has confirmed that it penetrates to the dermis layer. It possesses excellent DDS (Drug Delivery System) functionality to reliably convey internal information to the necessary cells. *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

Do you have any of these concerns? - I want to incorporate NMN into cosmetics, but it doesn't penetrate the skin. - It is weak against moisture and decomposes in aqueous solutions, leading to poor stability. - The efficiency of transmission into cells is low, making it difficult to exhibit effects. "Pentide-NMN" solves these issues. 【Feature 1】Excellent skin permeability and adhesion to cell membranes Regular NMN does not penetrate the skin, but Pentide-NMN has demonstrated an excellent skin permeability of 27.6% within 24 hours. Its high adhesion to cell membranes increases the contact rate with transporters, making it easier to be taken up by cells. 【Feature 2】High thermal stability in aqueous solutions It remains stable even in aqueous solutions, making it ideal for cosmetic formulations. In tests under conditions of 40°C, regular NMN completely decomposes after 3 days, while Pentide-NMN maintains 82.5% of its high activity even after 15 days. 【Feature 3】Conversion to NAD+ even at low concentrations After penetrating the skin, it is converted to NMN within the cell membrane and further converted to NAD+. *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

Do you have any of these concerns? - With conventional vitamin C derivatives, the mechanism of penetration into the skin and the release of free vitamin C is unclear. - I am looking for ingredients that can effectively work even at low concentrations while minimizing irritation. Pentide-C solves these issues. 【Feature 1】High bioavailability and innovative mechanism It penetrates the cell membrane regardless of the expression of vitamin C transporters, and vitamin C is effectively utilized within the cells as the peptide bonds are cleaved by intracellular enzymes (peptidases). This high bioavailability has been recognized, winning a gold award in the technology category at CITE JAPAN 2021. 【Feature 2】Collagen production ability from low concentrations Due to its high cell permeability, it shows collagen synthesis induction activity in human fibroblasts from a low concentration of 0.08µM. This is due to its unique mechanism that allows vitamin C to become free quickly, independent of transporters. *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

"RS Mixture 9.6E" is a human stem cell culture medium containing a large number of exosomes. By adding exosomes manufactured in a separate line, it has become possible to display exosomes in the full ingredient list. Since it is a liquid that has not been frozen or freeze-dried, it has high activity, and because it is in liquid form, it can be used in various formulations such as serums, introduction agents used with beauty devices, and professional products. 【Features】 ■ Contains a large number of exosomes ■ Exosomes can be displayed in the full ingredient list ■ Can appeal to consumers ■ Promotes collagen and hyaluronic acid biosynthesis ■ Has protective effects against oxidative stress *For more details, please refer to the PDF document or feel free to contact us.

• Cosmetic materials and raw materials

The "RS Liposome 3.0 Complex" is a high-performance penetrating cosmetic ingredient that combines "RS Liposome 3.0," which is liposome-encapsulated human stem cell culture fluid RemyStem, with the penetrating peptide vitamin C derivative "Pentide-C." "Pentide-C" has been confirmed to suppress the secretion of the inflammatory marker "TNF-α" secreted by monocytes stimulated with LPS, demonstrating anti-inflammatory effects. Additionally, it has been confirmed that the exosomes from RemyStem, when pre-added to keratinocytes, suppress damage caused by H2O2 and enhance the cells' antioxidant effects. 【Features】 ■ A material combining RS Liposome 3.0 and Pentide-C ■ Double penetration of the penetrating peptide vitamin C derivative and functional materials ■ Promotion of collagen production in fibroblasts ■ Anti-inflammatory effects of Pentide-C and antioxidant effects of RemyStem ■ Whitening effects and suppression of melanin production *For more details, please refer to the PDF document or feel free to contact us.

• Cosmetic materials and raw materials

"RemyStem" is a product that uses active substances such as "growth factors" and "exosomes" produced by stem cells as cosmetic ingredients. It can be provided in various forms, including standalone stem cell culture fluid, liposome processing, and mixtures with materials such as vitamin C derivatives. It controls the profile of physiologically active substances through biomimetic stimulation. 【Features】 ■ No animal-derived serum used ■ No antibiotics used ■ No hormones used ■ Controls the profile of physiologically active substances through biomimetic stimulation ■ Manufacturing standards based on MFDS guidelines *For more details, please refer to the PDF materials or feel free to contact us.

• Cosmetic materials and raw materials

"Pentide-C" is a stabilized vitamin C derivative that combines peptides with the hydroxyl group of vitamin C. Since vitamin C and peptides are linked by peptide bonds, after being taken up by cells, this bond undergoes hydrolysis by proteases. As a result, vitamin C becomes free, and data shows that its bioavailability is higher at low concentrations compared to pure vitamin C. [Features] ■ Penetration into the skin ■ Uptake by cells ■ Collagen production ■ Inhibition of melanin production ■ Antibacterial against Staphylococcus aureus *For more details, please refer to the PDF document or feel free to contact us.

• Fine chemicals (compounds, derivatives, catalysts, etc.)

"RemyEV-3" is a cosmetic ingredient that fuses stem cell exosomes secreted by human adipose-derived stem cells with liposomes of human stem cell culture fluid. It is expected to have a long presence in the body, improving the bioavailability of the components of stem cell culture fluid to deliver them to the necessary cells, allowing for prolonged action with a small amount. Please feel free to contact us if you have any inquiries. 【Features】 ■ Reverse aging effect ■ Strengthening of skin barrier ■ Anti-wrinkle effect ■ Defense against oxidative stress *For more details, please download the PDF or contact us.

• Cosmetic materials and raw materials

"RemyStem-JP" is a conditioned medium rich in protein components secreted by stem cells when adipose-derived stem cells are isolated and cultured from adipose tissue. Adipose-derived stem cells are a type of adult stem cell that can be more easily obtained than bone marrow-derived stem cells or umbilical cord blood-derived stem cells. Additionally, due to the high content of stem cells, they have been increasingly utilized in recent years as materials for regenerative medicine and cosmetics. 【Features】 ■ Anti-aging effects on aging cells ■ Promotion of collagen and hyaluronic acid biosynthesis ■ Whitening effects ■ Hair growth and thickening effects *For more details, please refer to the PDF document or feel free to contact us.

• Cosmetic materials and raw materials