アンチエイジング Product Lineup

We strongly support project and development personnel who want to plan new concept cosmetics and incorporate advanced trends such as exosomes and NMN. Our company provides free prototype samples (available in small lots starting from 1kg) of all handling ingredients so that you can utilize them from the initial stages of product planning. Additionally, we offer a comprehensive range of resources necessary for product commercialization, including data for creating brochures tailored to the product concept, academic evidence reports, and regulatory information regarding INCI and labeling names. Texture confirmation and formulation testing during prototyping can proceed smoothly. We provide supportive assistance for the rapid launch of new products. [Features] - Rapid provision of various ingredient samples useful in the early stages of planning - Support for small lot prototypes such as 1kg to 5kg and flexible supply - Provision of evidence that can be used for promotions and product packaging - Complete support for labeling names and regulations related to the Pharmaceutical and Medical Device Act *For more details, please check by downloading the catalog.

• Cosmetic materials and raw materials

In the aging care market, where customer needs are becoming more sophisticated, it is essential to have reliable material selection and advanced formulation development technology to create products that can compete successfully. Our company offers a comprehensive lineup of advanced premium materials with solid evidence, including human stem cell conditioned media "RemyStem," exosomes compliant with full ingredient labeling "RS Mixture 9.6E," high-penetration vitamin C "Pentide-C," and skin longevity ingredient "Pentide-NMN." We propose combinations of raw materials and formulation balances tailored to target demographics and price ranges (cost design) for clinic-exclusive products, professional salon materials, and D2C brands. We provide total support, from stability testing to solving formulation challenges. **Features** - A range of materials covering stem cells, exosomes, VC, and NMN - Suitable formulation proposals based on target demographics and costs - Technical know-how regarding stability and compatibility during formulation - One-stop solutions for OEM manufacturing and formulation development challenges *For more details, please check "Download Catalog."*

• Cosmetic materials and raw materials

We introduce cosmetic active ingredients that apply advanced biotechnology and regenerative medicine research. Our "RemyStem" and related materials are active components that not only provide superficial hydration but also directly act on cell receptors and signaling pathways. In in vitro experiments, data has shown that they enhance the proliferation and migration ability of human keratinocytes (HaCaT), strengthening skin barrier function, suppress melanin production in melanocytes, and induce the expression of vimentin and growth factors (KGF, IGF-1, etc.) that promote hair growth, demonstrating multifaceted physiological activity applicable in scalp care and hair growth fields. They are well-suited for concept cosmetics that emphasize functionality. 【Features】 ■ Enhances the migration ability of keratinocytes and strengthens skin barrier function ■ Strong melanin suppression against melanocyte stimulation ■ Hair growth and scalp care through vimentin expression and KGF promotion ■ Active ingredients that directly approach cell signals *For more details, please check "Download Catalog."

• Cosmetic materials and raw materials

We offer a "RemyStem" raw liquid lineup that does not involve dilution or excessive processing, specifically for salon-use introduction liquids and high-end anti-aging beauty serums. This lineup is concentrated with various growth factors such as VEGF, TGF-β, FGF, and IGF-1, which are secreted during the culture process of fat-derived stem cells, as well as enzyme proteins like collagen, hyaluronic acid, and SOD. It effectively prevents skin aging and damage while strongly activating the proliferation of fibroblasts and keratinocytes. In addition to the raw liquid zone, you can choose from a wide range of grades, including liposome zones (RS Liposome 1.0/3.0/5.0) that enhance biocompatibility according to your application and budget, as well as high-concentration zones using EXO-SAVE technology. 【Features】 ■ High-purity human stem cell conditioned culture liquid raw liquid specification ■ Rich in growth factors (EGF, FGF, etc.) and physiologically active substances ■ A wide range of grades from raw liquid to liposome processing ■ Suitable for professional beauty equipment introduction liquids and high-end beauty serums *For more details, please check "Download Catalog."

• Cosmetic materials and raw materials

Anti-Aging Co., Ltd. is a specialized manufacturer of high-performance aging care ingredients, delivering high-quality human stem cell conditioned medium "RemyStem" at an affordable price with a reliable supply system. Our "RemyStem" involves the careful selection and uniform separation and cultivation of adipose-derived stem cells. By adopting our unique know-how of "Rolling Bottle Culture," which rotates bottles 24 hours a day while providing oxygen, physical, and pharmacological stimuli, we have increased the amount of secreted proteins and functional exosomes to about ten times that of conventional culture methods. With quality assurance, traceability, and technical support unique to direct sales from a raw material manufacturer, we strongly support the development of your products. 【Features】 ■ Direct sales and stable supply from a raw material specialized manufacturer ■ Approximately ten times the effective ingredient amount through Rolling Bottle Culture ■ Established technology for uniform separation and purification of adipose-derived stem cells ■ Technical support and data provision unique to the manufacturer *For details, please check "Download Catalog."

• Cosmetic materials and raw materials

When incorporating NMN (Nicotinamide Mononucleotide) into cosmetics in Japan, there are existing patents for incorporation in the range of 0.001% to 10%. Therefore, using regular NMN powder directly poses a risk of patent infringement. "Pentide-NMN" is a new ingredient derived from the precursor of NMN, and its different chemical structure does not infringe on existing NMN incorporation patents. The INCI name (Dihydroniacinamide Riboside Acetyl Tri-t-Butyl Tryptophanate) and the full ingredient display name "Dihydroniacinamide Riboside Acetyl Tri-Butyl Tryptophan" have been officially obtained. You can safely commercialize products under the concepts of "NMN derivatives" and "skin longevity" while completely avoiding legal risks. 【Features】 ■ Does not infringe on existing NMN incorporation patents (0.001-10%) ■ INCI name and full ingredient display name officially obtained ■ Compliant with pharmaceutical and labeling regulations for commercialization ■ A reliable NMN concept that avoids patent risks *For more details, please check by downloading the catalog.

• Cosmetic materials and raw materials

Pentide-NMN" is chosen for the development of high-end cosmetics that require immediate effectiveness and a reliable experience, such as exclusive products for beauty clinics and salons. In multiple human application tests involving subjects (cream with 3% formulation), the promotion of the turnover cycle of the stratum corneum was confirmed in just 3 to 10 days. Furthermore, with continued use for 2 to 4 weeks, statistically significant improvements (p < 0.001) were demonstrated in the length and depth of wrinkles around the eyes, as well as in the brightness of the skin in areas of pigmentation. Additionally, in a skin irritation test (patch test) conducted on 32 individuals, an irritation index of 0.00 (non-irritating) was determined. This ingredient is suitable for professional use, combining high safety and top-tier clinical data. 【Features】 ■ Improves the length and depth of wrinkles around the eyes in human application tests ■ Promotes the turnover cycle in just 3 to 10 days ■ Determined to have MII = 0.00 (non-irritating) in skin irritation tests ■ Quality suitable for doctor's cosmetics and salon-exclusive products *For more details, please check "Download Catalog.

• Cosmetic materials and raw materials

We propose a liposome formulation of the high-performance NMN derivative "Pentide-NMN" to efficiently deliver the coenzyme NAD+—the key to skin longevity (cellular longevity)—into cells. This ingredient combines a tryptophan structure with high adhesion to cell membranes and liposome encapsulation technology, promoting endocytosis and achieving an extremely high intracellular delivery efficiency that surpasses transporter dependence. In a fibroblast aging model, we successfully increased the expression of the rejuvenating gene "Sirtuin 1 (SIRT1)" to a level overwhelmingly higher than that of regular NMN. Thanks to nanocapsule technology, it smoothly penetrates deep into the skin, making it suitable for high-end anti-aging products that awaken health from the foundation of the skin. 【Features】 ■ Achieves high penetration with liposome technology and amphiphilic structure ■ Significantly increases intracellular delivery rate and NAD+ production ■ Strongly enhances the expression of the longevity gene Sirtuin 1 ■ Restores NAD+ levels decreased by chronic inflammation and prevents aging *For details, please check by downloading the catalog.

• Cosmetic materials and raw materials

Regular NMN is extremely unstable in aqueous solution and has the drawback of completely decomposing within just three days at 40°C. Our "Pentide-NMN" boasts excellent thermal stability, maintaining a high residual rate of 82.5% even after 15 days at 40°C, thanks to steric hindrance from hydrophobic functional groups that prevent the intrusion of water molecules. Furthermore, in the Franz Diffusion Cell test, it demonstrated an excellent skin permeability of 27.6% within 24 hours. We have obtained numerous in vitro data, including the recovery effect of NAD+ in aged fibroblasts, reduction of SA-β-GAL, elimination of reactive oxygen species (ROS), and improvement of cell division rate. We confidently recommend this to researchers and developers seeking reliable evidence. 【Features】 ■ Maintains 82.5% activity even after 15 days at 40°C ■ Proven 27.6% skin permeability in the Franz test within 24 hours ■ Recovers NAD+ in aged cells and reduces SA-β-GAL ■ Demonstrates elimination of reactive oxygen species (ROS) and promotion of cell division *For more details, please check "Download Catalog."

• Cosmetic materials and raw materials

NMN (Nicotinamide Mononucleotide), which is gaining global attention as an anti-aging care ingredient, has faced serious challenges with conventional NMN powder, such as "immediate decomposition in water," "repulsion by sebum leading to poor transdermal absorption," and "issues with patenting for formulations." "Pentide-NMN" is a cosmetic-grade ingredient that combines a cell-permeable tryptophan with the precursor of NMN (derivatization). Thanks to its amphiphilic structure, it smoothly penetrates the skin without being repelled by sebum and maintains extremely high stability in aqueous solutions. It has a display name (Dihydronicotinamide Riboside Acetyl Tributyl Tryptophan) that does not infringe on NMN formulation patents, supporting the safe and reliable development of NMN cosmetics. 【Features】 ■ Achieves excellent cosmetic stability that does not decompose in water ■ Ensures superior transdermal absorption due to its amphiphilic structure ■ Display name that does not infringe on prior NMN formulation patents ■ Strongly promotes the expression of longevity gene SIRT1 *For more details, please check by downloading the catalog.

• Cosmetic materials and raw materials

We propose OEM and planning development to differentiate from the vitamin C cosmetics overflowing in the market. Our "Pentide-C" has a proven track record in a clinical trial with 24 participants using a cream containing only 0.0005% (equivalent to about 5% in raw material). Daily application showed statistically significant improvements in all categories, including "facial wrinkles," "skin brightness," and "melanin index," within just 2 to 4 weeks. The recommended concentration is 1% or more, which allows for sufficient effectiveness at a low concentration, making it possible to create low-irritation formulations that are less likely to cause skin troubles. It is provided as a highly permeable and stable liquid raw material, making it easy to add to existing OEM formulations. [Features] - Improves wrinkles, melanin, and brightness in human clinical trials - Low irritation and reliable sensory experience at recommended concentrations of 1% or more - Easily incorporated into existing formulations due to its liquid form - Development of vitamin C cosmetics with a differentiation story *For more details, please check by downloading the catalog.

• Cosmetic materials and raw materials

We propose high-quality cosmetic ingredients that encapsulate the highly functional vitamin C derivative "Pentide-C" in a liposome structure with high biocompatibility. Pentide-C, which is water-soluble and has excellent thermal stability, further improves its compatibility with the skin barrier through liposome processing. Fluorescent imaging analysis of tissue slides has confirmed that it penetrates deeply through the epidermis to the dermis layer. As a liquid ingredient that completely overcomes the disadvantages of vitamin C, which is prone to discoloration and browning, it can be incorporated without compromising transparency into lotions, serums, emulsions, creams, and even introduction liquids for beauty devices. With high bioavailability and penetration technology, it is suitable for developing products in the prestige price range. [Features] ■ Stabilization of high-penetration vitamin C using liposome technology ■ Excellent delivery system that reaches deep into the dermis layer ■ Liquid ingredient that resolves issues of discoloration, browning, and formulation restrictions ■ Proven improvement in wrinkles and skin brightness through human clinical trials *For details, please check "Download Catalog."

• Cosmetic materials and raw materials

The peptide used for stabilizing vitamin C itself plays a multifunctional role, "Pentide-C." Unlike conventional derivatives, the bonded peptide possesses both cell membrane permeability and antibacterial properties. Through a receptor-independent permeation mechanism, it demonstrates a powerful collagen production promotion ability that exceeds that of pure vitamin C, even at low concentrations (0.08μM and above), and excels in activating aged fibroblasts. Additionally, it has been confirmed to suppress melanin production and inhibit inflammatory cytokines (TNF-α) by over 87% due to LPS stimulation, as well as exhibiting bactericidal action against Staphylococcus aureus. It possesses excellent thermal stability, maintaining approximately 89.7% activity even after being left at 40°C for 30 days, enabling the formulation of low-irritation and high-quality skincare products. 【Features】 ■ High bioavailability and excellent effects even at low concentrations ■ Strongly promotes collagen production in aged fibroblasts ■ Suppresses inflammatory cytokine TNF-α by over 87% ■ Maintains excellent antibacterial action against Staphylococcus aureus *For more details, please check by downloading the catalog.

• Cosmetic materials and raw materials

"Pentide-C" is a groundbreaking vitamin C derivative that combines a cell-permeable peptide with the hydroxyl group of vitamin C. Conventional vitamin C derivatives have had the challenge of being difficult to penetrate the skin and convert into free vitamin C within cells. Pentide-C does not rely on receptors (vitamin C transporters) and directly penetrates the stratum corneum to reach the dermis and the interior of cells through the action of permeable peptides. The bond is hydrolyzed by intracellular peptidases, exhibiting excellent effects as pure vitamin C. It has demonstrated an impressive skin penetration rate of 26.6% in the Franz Diffusion Cell test and boasts a proven track record, having won the Gold Award in the Technology Category at the CITE JAPAN 2021 Awards. [Features] - Winner of the Gold Award in the Technology Category at the CITE JAPAN 2021 Awards - Achieves high cell permeability without dependence on transporters - Functions as pure vitamin C after being broken down within cells - Demonstrated excellent skin penetration of 26.6% in the Franz test *For more details, please check by downloading the catalog.

• Cosmetic materials and raw materials

To companies considering the development of unique cosmetics that are completely differentiated from other brands, we propose our contract manufacturing service "RemyEV-Carrier." This service utilizes your company's water-soluble active ingredients and original plant extracts, processing them into liposomes and fusing them with the membranes of exosomes secreted from stem cells, creating a hybrid exosome production technology. Thanks to the functions of tetraspanning proteins on the surface of exosomes, it is possible to selectively deliver original ingredients to target cells (such as fibroblasts and keratinocytes). Furthermore, we can expect a synergistic effect with the reverse aging effects (such as miRNA) that the exosomes themselves possess. We will build completely original raw materials without any overlap. 【Features】 ■ Exosome-encapsulated original ingredients unique to your company ■ DDS that selectively delivers ingredients to target cells ■ Construction of completely original raw materials differentiated from other companies ■ Synergistic effects with the beauty benefits of the exosomes themselves *For more details, please check by downloading the catalog.

• Cosmetic materials and raw materials

In the planning and development of new products, early sample evaluation and stability testing are key to success. Our company offers various sample materials of exosome ingredients tailored to your development concept, including high-concentration exosome-containing material "RemyStem," "RS Mixture 9.6E" compliant with full ingredient labeling, and the high-penetration liposome "RS Liposome" series. As a liquid material, it can be easily blended into a wide range of formulations, from serums and lotions to creams and professional introduction agents. We also support small lot sizes from 1kg to 5kg and provide technical documentation and various evidence data, ensuring speedy backup from the prototype stage to commercialization. Please feel free to request more information. 【Features】 ■ Rapid shipping of raw material samples convenient for evaluation and prototyping ■ Applicable to a variety of formulations such as serums and creams ■ Support for small lot introduction and prototyping consultations starting from 1kg ■ Simultaneous provision of necessary technical data and specifications for blending *For details, please check "Download Catalog."

• Cosmetic materials and raw materials

The stem cell exosomes secreted from human adipose-derived stem cells, which are gaining attention in the field of regenerative medicine, are vesicles (50-150 nm) responsible for intercellular communication and play an essential role in wound healing and cell activation. Our "RemyStem" series contains a high concentration of growth factors (such as EGF, FGF, VEGF) and functional exosomes through unique biomimetic stimulation and rolling bottle culture. By adding it to fibroblasts artificially aged by ultraviolet light, the reverse aging effect that suppresses the secretion of SA-β-GAL and resumes cell division has been demonstrated. It is a premium anti-aging care ingredient that covers wrinkle improvement, whitening, and strengthening the skin barrier. 【Features】 ■ High-quality exosomes from human adipose-derived stem cells ■ Optimization of ingredients through biomimetic stimulation ■ Reverse aging of aged fibroblasts ■ Rich in growth factors and functional proteins *For more details, please check by downloading the catalog.

• Cosmetic materials and raw materials

While general human stem cell conditioned media typically contains exosomes, there has been a challenge in clearly stating "exosomes" on packaging and ingredient lists, as they are collectively categorized under "human stem cell conditioned media." Our "RS Mixture 9.6E" is a groundbreaking ingredient that allows for the labeling of "human adipose-derived mesenchymal stem cell exosomes" in the ingredient list by adding concentrated exosomes produced in a separate line to the stem cell culture medium. It is a highly active liquid ingredient that does not undergo freeze-drying or freezing, which raises concerns about inactivation, and it allows for a strong appeal of exosomes in accordance with pharmaceutical and labeling regulations as consumer awareness increases. It is recommended for brands looking to differentiate themselves from other products. **Features** - "Exosomes" can be clearly stated in the ingredient list - Achieves strong appeal on packaging and promotional materials - Maintains high cell activity with a non-frozen liquid ingredient - Clears labeling rules and reduces risks under pharmaceutical laws *For more details, please check by downloading the catalog.*

• Cosmetic materials and raw materials

Prioritizing safety as a cosmetic ingredient, our human stem cell conditioned medium "RemyStem" and exosome materials are produced under strict manufacturing management. In the manufacturing process, we do not use any animal-derived serum, antibiotics, or hormones, and we adopt rolling bottle culture using a highly safe serum-free medium. Furthermore, we comply with stringent manufacturing standards based on the MFDS (Ministry of Food and Drug Safety of Korea) guidelines, and we have cleared all nine items of cosmetic safety evaluation tests, including human skin patch tests, single-dose oral toxicity tests, eye mucosa irritation tests, skin sensitization tests, and genotoxicity tests. Major and medium-sized cosmetic manufacturers that prioritize risk avoidance and quality assurance, as well as OEM companies dealing with doctor's cosmetics, can adopt our products with confidence. 【Features】 ■ No animal-derived serum, antibiotics, or hormones used ■ Cleared all nine cosmetic safety tests ■ Strict manufacturing and quality control in accordance with MFDS standards ■ High safety demonstrated through patch tests and toxicity tests *For more details, please check "Download Catalog."

• Cosmetic materials and raw materials

Stem cell exosomes contained in stem cell culture medium are expected to have high beauty effects as vesicles responsible for intercellular information transmission. Our "RemyStem" and "RS Mixture 9.6E" achieve approximately ten times the usual exosome secretion amount through rolling bottle culture technology. We have demonstrated a rich exosome content through data from nano-tracking analysis and ELISA analysis (CD9, CD63 markers). Furthermore, we have abundant in vitro data on the rejuvenation effects of aged fibroblasts, promotion of hyaluronic acid and collagen biosynthesis, and suppression of melanin production. We provide suitable solutions for companies considering the development of high-function anti-aging cosmetics focused on evidence, as well as cosmetics for clinics. We are also flexible in responding to prototype development and formulation consultations. 【Features】 ■ Tenfold exosomes through rolling bottle culture ■ Presentation of quantitative data such as nano-tracking analysis ■ Proven promotion of collagen and hyaluronic acid production ■ Abundant evidence for anti-wrinkle and melanin suppression *For details, please check "Download Catalog."

• Cosmetic materials and raw materials

In the skincare industry, particularly in the field of anti-aging care, the permeability and stability of ingredients related to skin firmness and elasticity are essential. Conventional NMN has faced challenges such as being sensitive to moisture, easily decomposing, and having low permeability to the skin. These issues have made it difficult to fully realize the effectiveness of products. Our "Pentide-NMN" is a permeable NMN derivative developed specifically for cosmetics to address these challenges. 【Usage Scenarios】 - Anti-aging cosmetics (serums, creams, etc.) - Products aimed at improving skin firmness and elasticity - Formulations that want to stably incorporate NMN ingredients 【Benefits of Introduction】 - Improves permeability to the skin, making it easier to deliver ingredients. - High stability in aqueous solutions makes it suitable for cosmetic formulations. - Even at low concentrations, it is expected to convert to NAD+ within cells, supporting the expression of effects.

• Cosmetic materials and raw materials

In the cosmetics industry, pursuing whitening effects is crucial for meeting consumer needs. In particular, addressing skin concerns such as spots, freckles, and dullness requires the formulation of effective ingredients and technologies that maximize their effects. Pentide-C supports the resolution of challenges in the development of whitening cosmetics as a highly bioavailable vitamin C derivative. 【Usage Scenarios】 - Cosmetics that promote whitening effects - Anti-aging products - Products that enhance skin brightness and transparency 【Benefits of Introduction】 - Evidence of effectiveness based on human clinical trial results - Contributes to improvements in wrinkles, skin brightness, and melanin index - Creation of differentiation elements in product development

• Cosmetic materials and raw materials

In the esthetic salon industry, products that can effectively address customers' skin concerns and deliver high results are in demand. Particularly in treatments aimed at anti-aging and skin quality improvement, the technology to deliver active ingredients deep into the skin is crucial. RemyEV-3 enhances the penetration of ingredients through its DDS function, which combines human stem cell culture fluid and exosomes (hybrid exosomes), contributing to increased customer satisfaction. 【Usage Scenarios】 - Anti-aging treatments - Skin quality improvement treatments - Use as an introduction beauty serum 【Effects of Introduction】 - Increased customer satisfaction due to reverse aging effects - Reduction of skin troubles through enhanced skin barrier function - Provision of a youthful impression through anti-wrinkle effects *Hybrid exosomes are a registered trademark of Anti-Aging Co., Ltd.

• Cosmetic materials and raw materials

In the beauty clinic industry, there is a demand to promote skin regeneration for patients and enhance anti-aging effects. In particular, it is important to promote skin turnover and strengthen the skin's barrier function. RemyEV-3 is a cosmetic ingredient that combines human adipose-derived stem cell exosomes and human stem cell culture fluid liposomes (hybrid exosomes), and it is expected to have a prolonged effect with a small amount due to improved bioavailability. [Usage Scenarios] - Skin regeneration treatment - Anti-aging care - Skin quality improvement [Effects of Introduction] - Reverse aging effect - Strengthening of skin barrier - Anti-wrinkle effect *Hybrid exosomes are a registered trademark of Anti-Aging Co., Ltd.

• Cosmetic materials and raw materials

In the skincare industry, the permeability of active ingredients into the skin is a crucial factor that influences the effectiveness of products. In particular, there is the challenge that the skin's barrier function prevents sufficient penetration of these ingredients. RemyEV-3 is a cosmetic ingredient that combines liposomes of human stem cell culture fluid with exosomes derived from human adipose stem cells (hybrid exosomes). This enhances the bioavailability of the ingredients, allowing for expected effects even with small amounts. 【Usage Scenarios】 - Serums - Creams - Masks - Introductory serums 【Effects of Introduction】 - Improved permeability of active ingredients - Effective approach to the skin - Efficacy with small amounts *Hybrid exosomes are a registered trademark of Anti-Aging Co., Ltd.

• Cosmetic materials and raw materials

In the cosmetics industry, moisturizing is a crucial factor that influences customer satisfaction. For those with dry or sensitive skin, effective moisturizing ingredients are essential for enhancing the skin's barrier function and protecting it from external stimuli. RemyEV-3 is a cosmetic ingredient that combines human fat-derived stem cell exosomes with human stem cell culture fluid liposomes (hybrid exosomes). It increases bioavailability and provides long-lasting effects with a small amount, delivering superior moisturizing benefits. 【Usage Scenarios】 - Cosmetics aimed at enhancing moisturizing effects - Cosmetics designed to strengthen the skin's barrier function - Cosmetics for dry and sensitive skin 【Effects of Introduction】 - Delivers moisture deep into the skin, achieving sustained moisturizing effects - Strengthens the skin's barrier function, protecting it from external stimuli - Demonstrates effectiveness with a small amount, contributing to cost performance *Hybrid exosomes are a registered trademark of Anti-Aging Co., Ltd.

• Cosmetic materials and raw materials

Anti-Aging Co., Ltd. offers a variety of grades as a supplier of human stem cell culture fluid. Our raw materials are processed to enhance permeability to the stratum corneum, and they are categorized into three zones: raw liquid zone, liposome zone, and hybrid zone, based on the degree of processing. You can choose the raw materials according to your purpose.

• Cosmetic materials and raw materials

From "temporary moisturizing" to "supporting physiological functions." In response to the inadequacies of conventional moisturizing ingredients regarding the "natural strength of the skin" and "stagnation of turnover," 'Remy Stem' approaches these issues through the physiological actions of stem cells. 【1】Promotion of collagen and hyaluronic acid biosynthesis Active substances (paracrine factors) released by stem cells act on target cells. By receiving these, cells directly promote the biosynthesis processes of collagen and hyaluronic acid. 【2】High-efficiency information transmission via exosomes The encapsulated microvesicles "exosomes" move between cells while protecting internal components. They function as a new mechanism that complements conventional culture medium components and dramatically enhances the efficiency of information transmission. 【3】Normalization of turnover through growth factors Contains a balanced mix of EGF (supporting differentiation of epidermal cells) and FGF (supporting production of dermal matrix). This leads the delayed turnover due to aging back to a normal cycle. *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

This document is an introduction to the custom-made hybrid exosome raw material manufacturing service "RemyEV-Carrier." In addition to explanations of exosomes and hybrid exosomes, it includes a mechanism for delivering any original cosmetic ingredients to cells using the power of exosomes. This service enables the production of exosome cosmetics that are less likely to compete with other companies. [Contents] ■ Exosomes ■ Hybrid Exosomes ■ Custom-made Exosomes *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

This document is a technical material regarding the cosmetic ingredient "RemyEV-3," which is a fusion of human stem cell culture fluid liposomes and exosomes. In addition to the culture techniques for exosomes and in vitro data, it includes the collagen production effects of hybrid exosomes and the results of human clinical trials on wrinkles around the eyes. Improvements have been confirmed with statistical significance in the total length, depth, width, and maximum depth of wrinkles. [Contents (partial)] ■ Exosomes ■ Penetration of human stem cell culture fluid ■ In vitro data of hybrid exosomes ■ Effects of hybrid exosomes on wrinkles *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

This document is a technical report that provides a detailed explanation of the characteristics and functionality of the vitamin C derivative "Pentide-C." It includes verification results on skin permeability and cell membrane permeability, as well as test data related to collagen production promotion, anti-inflammatory effects, melanin production suppression, and antibacterial effects, presented alongside charts and graphs. As a new approach to enhance the bioavailability of vitamin C, we hope this will be useful in selecting cosmetic ingredients. [Contents] ■ Characteristics of Pentide-C (skin permeability, cell membrane permeability) ■ Functionality of Pentide-C (promotion of collagen production, anti-inflammatory effects, melanin production suppression, antibacterial effects) ■ Stability of Pentide-C ■ Discussion *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

This document is a technical material summarizing the functionality and safety data of the vitamin C derivative "Pentide-C," which utilizes cell-permeable peptides. In addition to explanations regarding its high bioavailability, it includes a wide range of verification data such as selectivity of cell membranes, cytotoxicity tests, effects on hybrid exosomes, and results from human clinical trials. Improvements in wrinkles, skin brightness, and melanin index have also been confirmed, making it a useful reference for product development. [Contents] ■ High bioavailability ■ Selectivity of cell membranes ■ Cytotoxicity ■ Effects on hybrid exosomes ■ Uptake by host cells ■ Human clinical trial results of Pentide-C *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

Do you have any of these concerns? - I want to meet consumer needs for the functionality of exosomes. - I want to clearly promote "exosomes" in the full ingredient list of cosmetics. RS Mixture 9.6E solves these issues. 【Feature 1】Ability to promote exosomes in the ingredient list Human stem cell culture fluid naturally contains exosomes, but they cannot usually be listed as an ingredient. This product allows for the addition of exosomes manufactured in a separate line, enabling the labeling of "human adipose-derived mesenchymal stem cell exosomes." 【Feature 2】Significant increase in exosome content By adding 1% concentrated exosomes, the number of exosome particles measured by nano-tracking analysis has increased by approximately 1.4 times. 【Feature 3】Diverse beauty effects High beauty effects are expected, including anti-aging effects on aging cells, reverse aging effects, and promotion of collagen and hyaluronic acid biosynthesis. *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

Do you have any of these concerns? - I want to incorporate NMN into cosmetics, but I'm struggling because it is not absorbed through the skin. - I am looking for ingredients with higher anti-aging effects against aging cells. "RS Liposome 3.0E NMN" will solve these issues. 【Feature 1】 Synergistic effect of human stem cell culture fluid and NMN NMN improves aging by turning on the genetic switch, while exosomes improve cellular aging by turning off the genetic switch. By combining these two, a synergistic effect that improves aging is expected. 【Feature 2】 Enhanced permeability NMN derivative Regular NMN is not absorbed through the skin and shows almost no permeability after 24 hours, but the permeable NMN derivative "Pentide-NMN" is processed to penetrate the skin. 【Feature 3】 Reverse aging effect through exosomes Exosomes secreted under RemyStem's culture conditions have been confirmed to rejuvenate fibroblasts that have aged due to UV exposure. *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

Do you have any of these concerns? - Looking for a combination of ingredients to enhance the effects of stem cell culture fluid - Wanting raw materials that have a strong synergistic effect on collagen production and skin whitening "RS Liposome 3.0 Complex" solves these issues. 【Feature 1】Synergistic effect of human stem cell culture fluid and vitamin C Vitamin C is necessary for cells to execute the information received from stem cells and to promote collagen polymerization. By formulating these two together, a synergistic effect can be expected, strongly promoting collagen production. 【Feature 2】Double penetration technology with different mechanisms To enhance penetration, we use liposome-processed human stem cell culture fluid and a derivative that delivers vitamin C using cell-permeable peptides, employing completely different approaches to ensure functional materials penetrate to the cells. *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

Do you have any of these concerns? - Looking for ingredients that help the skin produce beauty components like collagen and hyaluronic acid - Wanting to promote skin turnover and engage in anti-aging Remy Stem solves these issues. 【Feature 1】 The power of active substances produced by stem cells Stem cells, which are attracting attention in regenerative medicine, can send active substances to other cells. By receiving these substances, beauty components such as collagen and hyaluronic acid are produced. 【Feature 2】 New information transmission through exosomes In addition to traditional paracrine factors, we use exosomes, which are vesicles used for information transmission between cells, as cosmetic ingredients. 【Feature 3】 Contains diverse growth factors It includes a variety of growth factors such as EGF (epidermal growth factor) and FGF (fibroblast growth factor). *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

Do you have any of these concerns? - Looking for ingredients to revitalize cells that have decreased in activity due to aging. - Wanting to promote the production of collagen and hyaluronic acid to improve wrinkles and enhance skin beauty. RemyStem solves these issues. 【Feature 1】Reverse aging effect on aged fibroblasts When added to fibroblasts that have stopped dividing due to photoaging from UV rays and are secreting SA-β-galactosidase, the SA-β-galactosidase decreases and cell division begins. It has been confirmed that this ingredient that improves aging is a stem cell exosome. 【Feature 2】Promotion of collagen and hyaluronic acid biosynthesis In fibroblasts, the production of collagen (Type I) and hyaluronic acid, which are major components of skin tissue, is increased in a concentration-dependent manner. This is expected to lead to effects such as wrinkle improvement and anti-aging. *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

Do you have any of these concerns? - I want to ensure that the components of stem cell culture fluid are delivered to the necessary cells. - I am looking for cosmetic ingredients that have a high in vivo utilization rate and act effectively in small amounts over a long period. RemyEV-3 solves these issues. 【Feature 1】Fusion of Exosomes and Liposomes Both exosomes and human stem cell culture fluid liposomes have membranes made of phospholipids, resulting in hybrid exosomes formed by their fusion. This creates particles of approximately 100nm. 【Feature 2】Dramatic Improvement in In Vivo Utilization Rate Thanks to the functions of antigens on the surface of exosomes, immune cell attacks are suppressed, allowing them to exist longer in the body. This significantly enhances the biocompatibility and in vivo utilization rate of the bioactive substances in human stem cell culture fluid. 【Feature 3】Reliable Permeability to the Dermis Fluorescent imaging analysis using FCM tissue has confirmed that it penetrates to the dermis layer. It possesses excellent DDS (Drug Delivery System) functionality to reliably convey internal information to the necessary cells. *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

Do you have any of these concerns? - I want to incorporate NMN into cosmetics, but it doesn't penetrate the skin. - It is weak against moisture and decomposes in aqueous solutions, leading to poor stability. - The efficiency of transmission into cells is low, making it difficult to exhibit effects. "Pentide-NMN" solves these issues. 【Feature 1】Excellent skin permeability and adhesion to cell membranes Regular NMN does not penetrate the skin, but Pentide-NMN has demonstrated an excellent skin permeability of 27.6% within 24 hours. Its high adhesion to cell membranes increases the contact rate with transporters, making it easier to be taken up by cells. 【Feature 2】High thermal stability in aqueous solutions It remains stable even in aqueous solutions, making it ideal for cosmetic formulations. In tests under conditions of 40°C, regular NMN completely decomposes after 3 days, while Pentide-NMN maintains 82.5% of its high activity even after 15 days. 【Feature 3】Conversion to NAD+ even at low concentrations After penetrating the skin, it is converted to NMN within the cell membrane and further converted to NAD+. *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

Do you have any of these concerns? - With conventional vitamin C derivatives, the mechanism of penetration into the skin and the release of free vitamin C is unclear. - I am looking for ingredients that can effectively work even at low concentrations while minimizing irritation. Pentide-C solves these issues. 【Feature 1】High bioavailability and innovative mechanism It penetrates the cell membrane regardless of the expression of vitamin C transporters, and vitamin C is effectively utilized within the cells as the peptide bonds are cleaved by intracellular enzymes (peptidases). This high bioavailability has been recognized, winning a gold award in the technology category at CITE JAPAN 2021. 【Feature 2】Collagen production ability from low concentrations Due to its high cell permeability, it shows collagen synthesis induction activity in human fibroblasts from a low concentration of 0.08µM. This is due to its unique mechanism that allows vitamin C to become free quickly, independent of transporters. *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

For cosmetic manufacturers, procuring high-quality cosmetic ingredients is essential for product differentiation and improving customer satisfaction. In particular, the incorporation of stem cell culture fluid has become an important factor in pursuing skin benefits. However, depending on the quality, form, and blending methods of the ingredients, the expected effects may not be achieved, or issues with product stability may arise. RemyStem is a product that uses active substances such as growth factors and exosomes produced by stem cells as cosmetic ingredients. It can be provided in various forms and supports optimal blending for your products. 【Usage Scenarios】 - Anti-aging products - Whitening products - Products for sensitive skin - Scalp care products 【Benefits of Introduction】 - Increased product added value - Improved customer satisfaction - Differentiation from competitor products - Support for diverse product development

• Cosmetic materials and raw materials

"RS Mixture 9.6E" is a human stem cell culture medium containing a large number of exosomes. By adding exosomes manufactured in a separate line, it has become possible to display exosomes in the full ingredient list. Since it is a liquid that has not been frozen or freeze-dried, it has high activity, and because it is in liquid form, it can be used in various formulations such as serums, introduction agents used with beauty devices, and professional products. 【Features】 ■ Contains a large number of exosomes ■ Exosomes can be displayed in the full ingredient list ■ Can appeal to consumers ■ Promotes collagen and hyaluronic acid biosynthesis ■ Has protective effects against oxidative stress *For more details, please refer to the PDF document or feel free to contact us.

• Cosmetic materials and raw materials

The "RS Liposome 3.0 Complex" is a high-performance penetrating cosmetic ingredient that combines "RS Liposome 3.0," which is liposome-encapsulated human stem cell culture fluid RemyStem, with the penetrating peptide vitamin C derivative "Pentide-C." "Pentide-C" has been confirmed to suppress the secretion of the inflammatory marker "TNF-α" secreted by monocytes stimulated with LPS, demonstrating anti-inflammatory effects. Additionally, it has been confirmed that the exosomes from RemyStem, when pre-added to keratinocytes, suppress damage caused by H2O2 and enhance the cells' antioxidant effects. 【Features】 ■ A material combining RS Liposome 3.0 and Pentide-C ■ Double penetration of the penetrating peptide vitamin C derivative and functional materials ■ Promotion of collagen production in fibroblasts ■ Anti-inflammatory effects of Pentide-C and antioxidant effects of RemyStem ■ Whitening effects and suppression of melanin production *For more details, please refer to the PDF document or feel free to contact us.

• Cosmetic materials and raw materials

"RemyStem" is a product that uses active substances such as "growth factors" and "exosomes" produced by stem cells as cosmetic ingredients. It can be provided in various forms, including standalone stem cell culture fluid, liposome processing, and mixtures with materials such as vitamin C derivatives. It controls the profile of physiologically active substances through biomimetic stimulation. 【Features】 ■ No animal-derived serum used ■ No antibiotics used ■ No hormones used ■ Controls the profile of physiologically active substances through biomimetic stimulation ■ Manufacturing standards based on MFDS guidelines *For more details, please refer to the PDF materials or feel free to contact us.

• Cosmetic materials and raw materials

"Pentide-C" is a stabilized vitamin C derivative that combines peptides with the hydroxyl group of vitamin C. Since vitamin C and peptides are linked by peptide bonds, after being taken up by cells, this bond undergoes hydrolysis by proteases. As a result, vitamin C becomes free, and data shows that its bioavailability is higher at low concentrations compared to pure vitamin C. [Features] ■ Penetration into the skin ■ Uptake by cells ■ Collagen production ■ Inhibition of melanin production ■ Antibacterial against Staphylococcus aureus *For more details, please refer to the PDF document or feel free to contact us.

• Fine chemicals (compounds, derivatives, catalysts, etc.)