アンチエイジング Product Lineup

In the skincare industry, particularly in the field of anti-aging care, the permeability and stability of ingredients related to skin firmness and elasticity are essential. Conventional NMN has faced challenges such as being sensitive to moisture, easily decomposing, and having low permeability to the skin. These issues have made it difficult to fully realize the effectiveness of products. Our "Pentide-NMN" is a permeable NMN derivative developed specifically for cosmetics to address these challenges. 【Usage Scenarios】 - Anti-aging cosmetics (serums, creams, etc.) - Products aimed at improving skin firmness and elasticity - Formulations that want to stably incorporate NMN ingredients 【Benefits of Introduction】 - Improves permeability to the skin, making it easier to deliver ingredients. - High stability in aqueous solutions makes it suitable for cosmetic formulations. - Even at low concentrations, it is expected to convert to NAD+ within cells, supporting the expression of effects.

• Cosmetic materials and raw materials

In the cosmetics industry, pursuing whitening effects is crucial for meeting consumer needs. In particular, addressing skin concerns such as spots, freckles, and dullness requires the formulation of effective ingredients and technologies that maximize their effects. Pentide-C supports the resolution of challenges in the development of whitening cosmetics as a highly bioavailable vitamin C derivative. 【Usage Scenarios】 - Cosmetics that promote whitening effects - Anti-aging products - Products that enhance skin brightness and transparency 【Benefits of Introduction】 - Evidence of effectiveness based on human clinical trial results - Contributes to improvements in wrinkles, skin brightness, and melanin index - Creation of differentiation elements in product development

• Cosmetic materials and raw materials

In the esthetic salon industry, products that can effectively address customers' skin concerns and deliver high results are in demand. Particularly in treatments aimed at anti-aging and skin quality improvement, the technology to deliver active ingredients deep into the skin is crucial. RemyEV-3 enhances the penetration of ingredients through its DDS function, which combines human stem cell culture fluid and exosomes (hybrid exosomes), contributing to increased customer satisfaction. 【Usage Scenarios】 - Anti-aging treatments - Skin quality improvement treatments - Use as an introduction beauty serum 【Effects of Introduction】 - Increased customer satisfaction due to reverse aging effects - Reduction of skin troubles through enhanced skin barrier function - Provision of a youthful impression through anti-wrinkle effects *Hybrid exosomes are a registered trademark of Anti-Aging Co., Ltd.

• Cosmetic materials and raw materials

In the beauty clinic industry, there is a demand to promote skin regeneration for patients and enhance anti-aging effects. In particular, it is important to promote skin turnover and strengthen the skin's barrier function. RemyEV-3 is a cosmetic ingredient that combines human adipose-derived stem cell exosomes and human stem cell culture fluid liposomes (hybrid exosomes), and it is expected to have a prolonged effect with a small amount due to improved bioavailability. [Usage Scenarios] - Skin regeneration treatment - Anti-aging care - Skin quality improvement [Effects of Introduction] - Reverse aging effect - Strengthening of skin barrier - Anti-wrinkle effect *Hybrid exosomes are a registered trademark of Anti-Aging Co., Ltd.

• Cosmetic materials and raw materials

In the skincare industry, the permeability of active ingredients into the skin is a crucial factor that influences the effectiveness of products. In particular, there is the challenge that the skin's barrier function prevents sufficient penetration of these ingredients. RemyEV-3 is a cosmetic ingredient that combines liposomes of human stem cell culture fluid with exosomes derived from human adipose stem cells (hybrid exosomes). This enhances the bioavailability of the ingredients, allowing for expected effects even with small amounts. 【Usage Scenarios】 - Serums - Creams - Masks - Introductory serums 【Effects of Introduction】 - Improved permeability of active ingredients - Effective approach to the skin - Efficacy with small amounts *Hybrid exosomes are a registered trademark of Anti-Aging Co., Ltd.

• Cosmetic materials and raw materials

In the cosmetics industry, moisturizing is a crucial factor that influences customer satisfaction. For those with dry or sensitive skin, effective moisturizing ingredients are essential for enhancing the skin's barrier function and protecting it from external stimuli. RemyEV-3 is a cosmetic ingredient that combines human fat-derived stem cell exosomes with human stem cell culture fluid liposomes (hybrid exosomes). It increases bioavailability and provides long-lasting effects with a small amount, delivering superior moisturizing benefits. 【Usage Scenarios】 - Cosmetics aimed at enhancing moisturizing effects - Cosmetics designed to strengthen the skin's barrier function - Cosmetics for dry and sensitive skin 【Effects of Introduction】 - Delivers moisture deep into the skin, achieving sustained moisturizing effects - Strengthens the skin's barrier function, protecting it from external stimuli - Demonstrates effectiveness with a small amount, contributing to cost performance *Hybrid exosomes are a registered trademark of Anti-Aging Co., Ltd.

• Cosmetic materials and raw materials

Anti-Aging Co., Ltd. offers a variety of grades as a supplier of human stem cell culture fluid. Our raw materials are processed to enhance permeability to the stratum corneum, and they are categorized into three zones: raw liquid zone, liposome zone, and hybrid zone, based on the degree of processing. You can choose the raw materials according to your purpose.

• Cosmetic materials and raw materials

From "temporary moisturizing" to "supporting physiological functions." In response to the inadequacies of conventional moisturizing ingredients regarding the "natural strength of the skin" and "stagnation of turnover," 'Remy Stem' approaches these issues through the physiological actions of stem cells. 【1】Promotion of collagen and hyaluronic acid biosynthesis Active substances (paracrine factors) released by stem cells act on target cells. By receiving these, cells directly promote the biosynthesis processes of collagen and hyaluronic acid. 【2】High-efficiency information transmission via exosomes The encapsulated microvesicles "exosomes" move between cells while protecting internal components. They function as a new mechanism that complements conventional culture medium components and dramatically enhances the efficiency of information transmission. 【3】Normalization of turnover through growth factors Contains a balanced mix of EGF (supporting differentiation of epidermal cells) and FGF (supporting production of dermal matrix). This leads the delayed turnover due to aging back to a normal cycle. *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

This document is an introduction to the custom-made hybrid exosome raw material manufacturing service "RemyEV-Carrier." In addition to explanations of exosomes and hybrid exosomes, it includes a mechanism for delivering any original cosmetic ingredients to cells using the power of exosomes. This service enables the production of exosome cosmetics that are less likely to compete with other companies. [Contents] ■ Exosomes ■ Hybrid Exosomes ■ Custom-made Exosomes *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

This document is a technical material regarding the cosmetic ingredient "RemyEV-3," which is a fusion of human stem cell culture fluid liposomes and exosomes. In addition to the culture techniques for exosomes and in vitro data, it includes the collagen production effects of hybrid exosomes and the results of human clinical trials on wrinkles around the eyes. Improvements have been confirmed with statistical significance in the total length, depth, width, and maximum depth of wrinkles. [Contents (partial)] ■ Exosomes ■ Penetration of human stem cell culture fluid ■ In vitro data of hybrid exosomes ■ Effects of hybrid exosomes on wrinkles *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

This document is a technical report that provides a detailed explanation of the characteristics and functionality of the vitamin C derivative "Pentide-C." It includes verification results on skin permeability and cell membrane permeability, as well as test data related to collagen production promotion, anti-inflammatory effects, melanin production suppression, and antibacterial effects, presented alongside charts and graphs. As a new approach to enhance the bioavailability of vitamin C, we hope this will be useful in selecting cosmetic ingredients. [Contents] ■ Characteristics of Pentide-C (skin permeability, cell membrane permeability) ■ Functionality of Pentide-C (promotion of collagen production, anti-inflammatory effects, melanin production suppression, antibacterial effects) ■ Stability of Pentide-C ■ Discussion *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

This document is a technical material summarizing the functionality and safety data of the vitamin C derivative "Pentide-C," which utilizes cell-permeable peptides. In addition to explanations regarding its high bioavailability, it includes a wide range of verification data such as selectivity of cell membranes, cytotoxicity tests, effects on hybrid exosomes, and results from human clinical trials. Improvements in wrinkles, skin brightness, and melanin index have also been confirmed, making it a useful reference for product development. [Contents] ■ High bioavailability ■ Selectivity of cell membranes ■ Cytotoxicity ■ Effects on hybrid exosomes ■ Uptake by host cells ■ Human clinical trial results of Pentide-C *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

Do you have any of these concerns? - I want to meet consumer needs for the functionality of exosomes. - I want to clearly promote "exosomes" in the full ingredient list of cosmetics. RS Mixture 9.6E solves these issues. 【Feature 1】Ability to promote exosomes in the ingredient list Human stem cell culture fluid naturally contains exosomes, but they cannot usually be listed as an ingredient. This product allows for the addition of exosomes manufactured in a separate line, enabling the labeling of "human adipose-derived mesenchymal stem cell exosomes." 【Feature 2】Significant increase in exosome content By adding 1% concentrated exosomes, the number of exosome particles measured by nano-tracking analysis has increased by approximately 1.4 times. 【Feature 3】Diverse beauty effects High beauty effects are expected, including anti-aging effects on aging cells, reverse aging effects, and promotion of collagen and hyaluronic acid biosynthesis. *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

Do you have any of these concerns? - I want to incorporate NMN into cosmetics, but I'm struggling because it is not absorbed through the skin. - I am looking for ingredients with higher anti-aging effects against aging cells. "RS Liposome 3.0E NMN" will solve these issues. 【Feature 1】 Synergistic effect of human stem cell culture fluid and NMN NMN improves aging by turning on the genetic switch, while exosomes improve cellular aging by turning off the genetic switch. By combining these two, a synergistic effect that improves aging is expected. 【Feature 2】 Enhanced permeability NMN derivative Regular NMN is not absorbed through the skin and shows almost no permeability after 24 hours, but the permeable NMN derivative "Pentide-NMN" is processed to penetrate the skin. 【Feature 3】 Reverse aging effect through exosomes Exosomes secreted under RemyStem's culture conditions have been confirmed to rejuvenate fibroblasts that have aged due to UV exposure. *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

Do you have any of these concerns? - Looking for a combination of ingredients to enhance the effects of stem cell culture fluid - Wanting raw materials that have a strong synergistic effect on collagen production and skin whitening "RS Liposome 3.0 Complex" solves these issues. 【Feature 1】Synergistic effect of human stem cell culture fluid and vitamin C Vitamin C is necessary for cells to execute the information received from stem cells and to promote collagen polymerization. By formulating these two together, a synergistic effect can be expected, strongly promoting collagen production. 【Feature 2】Double penetration technology with different mechanisms To enhance penetration, we use liposome-processed human stem cell culture fluid and a derivative that delivers vitamin C using cell-permeable peptides, employing completely different approaches to ensure functional materials penetrate to the cells. *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

Do you have any of these concerns? - Looking for ingredients that help the skin produce beauty components like collagen and hyaluronic acid - Wanting to promote skin turnover and engage in anti-aging Remy Stem solves these issues. 【Feature 1】 The power of active substances produced by stem cells Stem cells, which are attracting attention in regenerative medicine, can send active substances to other cells. By receiving these substances, beauty components such as collagen and hyaluronic acid are produced. 【Feature 2】 New information transmission through exosomes In addition to traditional paracrine factors, we use exosomes, which are vesicles used for information transmission between cells, as cosmetic ingredients. 【Feature 3】 Contains diverse growth factors It includes a variety of growth factors such as EGF (epidermal growth factor) and FGF (fibroblast growth factor). *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

Do you have any of these concerns? - Looking for ingredients to revitalize cells that have decreased in activity due to aging. - Wanting to promote the production of collagen and hyaluronic acid to improve wrinkles and enhance skin beauty. RemyStem solves these issues. 【Feature 1】Reverse aging effect on aged fibroblasts When added to fibroblasts that have stopped dividing due to photoaging from UV rays and are secreting SA-β-galactosidase, the SA-β-galactosidase decreases and cell division begins. It has been confirmed that this ingredient that improves aging is a stem cell exosome. 【Feature 2】Promotion of collagen and hyaluronic acid biosynthesis In fibroblasts, the production of collagen (Type I) and hyaluronic acid, which are major components of skin tissue, is increased in a concentration-dependent manner. This is expected to lead to effects such as wrinkle improvement and anti-aging. *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

Do you have any of these concerns? - I want to ensure that the components of stem cell culture fluid are delivered to the necessary cells. - I am looking for cosmetic ingredients that have a high in vivo utilization rate and act effectively in small amounts over a long period. RemyEV-3 solves these issues. 【Feature 1】Fusion of Exosomes and Liposomes Both exosomes and human stem cell culture fluid liposomes have membranes made of phospholipids, resulting in hybrid exosomes formed by their fusion. This creates particles of approximately 100nm. 【Feature 2】Dramatic Improvement in In Vivo Utilization Rate Thanks to the functions of antigens on the surface of exosomes, immune cell attacks are suppressed, allowing them to exist longer in the body. This significantly enhances the biocompatibility and in vivo utilization rate of the bioactive substances in human stem cell culture fluid. 【Feature 3】Reliable Permeability to the Dermis Fluorescent imaging analysis using FCM tissue has confirmed that it penetrates to the dermis layer. It possesses excellent DDS (Drug Delivery System) functionality to reliably convey internal information to the necessary cells. *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

Do you have any of these concerns? - I want to incorporate NMN into cosmetics, but it doesn't penetrate the skin. - It is weak against moisture and decomposes in aqueous solutions, leading to poor stability. - The efficiency of transmission into cells is low, making it difficult to exhibit effects. "Pentide-NMN" solves these issues. 【Feature 1】Excellent skin permeability and adhesion to cell membranes Regular NMN does not penetrate the skin, but Pentide-NMN has demonstrated an excellent skin permeability of 27.6% within 24 hours. Its high adhesion to cell membranes increases the contact rate with transporters, making it easier to be taken up by cells. 【Feature 2】High thermal stability in aqueous solutions It remains stable even in aqueous solutions, making it ideal for cosmetic formulations. In tests under conditions of 40°C, regular NMN completely decomposes after 3 days, while Pentide-NMN maintains 82.5% of its high activity even after 15 days. 【Feature 3】Conversion to NAD+ even at low concentrations After penetrating the skin, it is converted to NMN within the cell membrane and further converted to NAD+. *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

Do you have any of these concerns? - With conventional vitamin C derivatives, the mechanism of penetration into the skin and the release of free vitamin C is unclear. - I am looking for ingredients that can effectively work even at low concentrations while minimizing irritation. Pentide-C solves these issues. 【Feature 1】High bioavailability and innovative mechanism It penetrates the cell membrane regardless of the expression of vitamin C transporters, and vitamin C is effectively utilized within the cells as the peptide bonds are cleaved by intracellular enzymes (peptidases). This high bioavailability has been recognized, winning a gold award in the technology category at CITE JAPAN 2021. 【Feature 2】Collagen production ability from low concentrations Due to its high cell permeability, it shows collagen synthesis induction activity in human fibroblasts from a low concentration of 0.08µM. This is due to its unique mechanism that allows vitamin C to become free quickly, independent of transporters. *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials

For cosmetic manufacturers, procuring high-quality cosmetic ingredients is essential for product differentiation and improving customer satisfaction. In particular, the incorporation of stem cell culture fluid has become an important factor in pursuing skin benefits. However, depending on the quality, form, and blending methods of the ingredients, the expected effects may not be achieved, or issues with product stability may arise. RemyStem is a product that uses active substances such as growth factors and exosomes produced by stem cells as cosmetic ingredients. It can be provided in various forms and supports optimal blending for your products. 【Usage Scenarios】 - Anti-aging products - Whitening products - Products for sensitive skin - Scalp care products 【Benefits of Introduction】 - Increased product added value - Improved customer satisfaction - Differentiation from competitor products - Support for diverse product development

• Cosmetic materials and raw materials

"RS Mixture 9.6E" is a human stem cell culture medium containing a large number of exosomes. By adding exosomes manufactured in a separate line, it has become possible to display exosomes in the full ingredient list. Since it is a liquid that has not been frozen or freeze-dried, it has high activity, and because it is in liquid form, it can be used in various formulations such as serums, introduction agents used with beauty devices, and professional products. 【Features】 ■ Contains a large number of exosomes ■ Exosomes can be displayed in the full ingredient list ■ Can appeal to consumers ■ Promotes collagen and hyaluronic acid biosynthesis ■ Has protective effects against oxidative stress *For more details, please refer to the PDF document or feel free to contact us.

• Cosmetic materials and raw materials

The "RS Liposome 3.0 Complex" is a high-performance penetrating cosmetic ingredient that combines "RS Liposome 3.0," which is liposome-encapsulated human stem cell culture fluid RemyStem, with the penetrating peptide vitamin C derivative "Pentide-C." "Pentide-C" has been confirmed to suppress the secretion of the inflammatory marker "TNF-α" secreted by monocytes stimulated with LPS, demonstrating anti-inflammatory effects. Additionally, it has been confirmed that the exosomes from RemyStem, when pre-added to keratinocytes, suppress damage caused by H2O2 and enhance the cells' antioxidant effects. 【Features】 ■ A material combining RS Liposome 3.0 and Pentide-C ■ Double penetration of the penetrating peptide vitamin C derivative and functional materials ■ Promotion of collagen production in fibroblasts ■ Anti-inflammatory effects of Pentide-C and antioxidant effects of RemyStem ■ Whitening effects and suppression of melanin production *For more details, please refer to the PDF document or feel free to contact us.

• Cosmetic materials and raw materials

"RemyStem" is a product that uses active substances such as "growth factors" and "exosomes" produced by stem cells as cosmetic ingredients. It can be provided in various forms, including standalone stem cell culture fluid, liposome processing, and mixtures with materials such as vitamin C derivatives. It controls the profile of physiologically active substances through biomimetic stimulation. 【Features】 ■ No animal-derived serum used ■ No antibiotics used ■ No hormones used ■ Controls the profile of physiologically active substances through biomimetic stimulation ■ Manufacturing standards based on MFDS guidelines *For more details, please refer to the PDF materials or feel free to contact us.

• Cosmetic materials and raw materials

"Pentide-C" is a stabilized vitamin C derivative that combines peptides with the hydroxyl group of vitamin C. Since vitamin C and peptides are linked by peptide bonds, after being taken up by cells, this bond undergoes hydrolysis by proteases. As a result, vitamin C becomes free, and data shows that its bioavailability is higher at low concentrations compared to pure vitamin C. [Features] ■ Penetration into the skin ■ Uptake by cells ■ Collagen production ■ Inhibition of melanin production ■ Antibacterial against Staphylococcus aureus *For more details, please refer to the PDF document or feel free to contact us.

• Fine chemicals (compounds, derivatives, catalysts, etc.)

"RemyEV-3" is a cosmetic ingredient that fuses stem cell exosomes secreted by human adipose-derived stem cells with liposomes of human stem cell culture fluid. It is expected to have a long presence in the body, improving the bioavailability of the components of stem cell culture fluid to deliver them to the necessary cells, allowing for prolonged action with a small amount. Please feel free to contact us if you have any inquiries. 【Features】 ■ Reverse aging effect ■ Strengthening of skin barrier ■ Anti-wrinkle effect ■ Defense against oxidative stress *For more details, please download the PDF or contact us.

• Cosmetic materials and raw materials

"RemyStem-JP" is a conditioned medium rich in protein components secreted by stem cells when adipose-derived stem cells are isolated and cultured from adipose tissue. Adipose-derived stem cells are a type of adult stem cell that can be more easily obtained than bone marrow-derived stem cells or umbilical cord blood-derived stem cells. Additionally, due to the high content of stem cells, they have been increasingly utilized in recent years as materials for regenerative medicine and cosmetics. 【Features】 ■ Anti-aging effects on aging cells ■ Promotion of collagen and hyaluronic acid biosynthesis ■ Whitening effects ■ Hair growth and thickening effects *For more details, please refer to the PDF document or feel free to contact us.

• Cosmetic materials and raw materials