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アンチエイジング

Establishment2012年8月8日
addressTokyo/Minato-ku/3-4-6 Minami Aoyama, AOYAMA346 3F
phone03-3478-0248
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last updated:Apr 10, 2026
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RS Liposome 3.0E NMN RS Liposome 3.0E NMN
RS Liposome 3.0E Complex RS Liposome 3.0E Complex
RS Liposome 3.0 Complex RS Liposome 3.0 Complex
RS Liposome 1.0 / 3.0 / 5.0 RS Liposome 1.0 / 3.0 / 5.0
Pentide-NMN(Penetrating NMN derivative) Pentide-NMN(Penetrating NMN derivative)
Pentide-C(Penetrating vitamin C derivative) Pentide-C(Penetrating vitamin C derivative)
RemyEV(Hybrid exosomes) RemyEV(Hybrid exosomes)
RemyStem(Human stem cell conditioned medium) RemyStem(Human stem cell conditioned medium)
RS Mixture 9.6E RS Mixture 9.6E
RS Exosave(Exosome protection technology) RS Exosave(Exosome protection technology)
About the lineup About the lineup
Pentide-NMN(Penetrating

Pentide-NMN(Penetrating NMN derivative)

NMN (nicotinamide mononucleotide) is an anti-aging ingredient that is attracting attention as a supplement. However, when considered as a cosmetic ingredient, NMN (NR) is unsuitable for incorporation because it is not absorbed transdermally. 'Pentide-NMN' is an ingredient that applies penetration technology to NMN (NR), which is not absorbed transdermally. By using Pentide technology, which has the function of penetrating the stratum corneum, on an NMN (NR) derivative, the NMN derivative can be made to penetrate the skin.

A cosmetic-specific permeable NMN derivative that is stable in aqueous solution and penetrates the skin.

Improving the shortcomings of NMN, which is weak in water and does not absorb transdermally. This is a cosmetic-grade NMN ingredient that has high transmission efficiency into cells and demonstrates efficacy even at low concentrations.

Do you have any of these concerns? - I want to incorporate NMN into cosmetics, but it doesn't penetrate the skin. - It is weak against moisture and decomposes in aqueous solutions, leading to poor stability. - The efficiency of transmission into cells is low, making it difficult to exhibit effects. "Pentide-NMN" solves these issues. 【Feature 1】Excellent skin permeability and adhesion to cell membranes Regular NMN does not penetrate the skin, but Pentide-NMN has demonstrated an excellent skin permeability of 27.6% within 24 hours. Its high adhesion to cell membranes increases the contact rate with transporters, making it easier to be taken up by cells. 【Feature 2】High thermal stability in aqueous solutions It remains stable even in aqueous solutions, making it ideal for cosmetic formulations. In tests under conditions of 40°C, regular NMN completely decomposes after 3 days, while Pentide-NMN maintains 82.5% of its high activity even after 15 days. 【Feature 3】Conversion to NAD+ even at low concentrations After penetrating the skin, it is converted to NMN within the cell membrane and further converted to NAD+. *For more details, please download the PDF or feel free to contact us.

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Synergistic effects of human stem cell culture fluid and permeable NMN derivatives on aging improvement.

We aim for a synergistic anti-aging effect by combining exosomes that rejuvenate aged cells with NMN that expresses sirtuins.

Do you have any of these concerns? - I want to incorporate NMN into cosmetics, but I'm struggling because it is not absorbed through the skin. - I am looking for ingredients with higher anti-aging effects against aging cells. "RS Liposome 3.0E NMN" will solve these issues. 【Feature 1】 Synergistic effect of human stem cell culture fluid and NMN NMN improves aging by turning on the genetic switch, while exosomes improve cellular aging by turning off the genetic switch. By combining these two, a synergistic effect that improves aging is expected. 【Feature 2】 Enhanced permeability NMN derivative Regular NMN is not absorbed through the skin and shows almost no permeability after 24 hours, but the permeable NMN derivative "Pentide-NMN" is processed to penetrate the skin. 【Feature 3】 Reverse aging effect through exosomes Exosomes secreted under RemyStem's culture conditions have been confirmed to rejuvenate fibroblasts that have aged due to UV exposure. *For more details, please download the PDF or feel free to contact us.

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[For Skincare] Cosmetic-Specific Penetrating NMN Derivative

Strong against moisture and penetrates the skin. NMN ingredient that is effective even at low concentrations.

In the skincare industry, particularly in the field of anti-aging care, the permeability and stability of ingredients related to skin firmness and elasticity are essential. Conventional NMN has faced challenges such as being sensitive to moisture, easily decomposing, and having low permeability to the skin. These issues have made it difficult to fully realize the effectiveness of products. Our "Pentide-NMN" is a permeable NMN derivative developed specifically for cosmetics to address these challenges. 【Usage Scenarios】 - Anti-aging cosmetics (serums, creams, etc.) - Products aimed at improving skin firmness and elasticity - Formulations that want to stably incorporate NMN ingredients 【Benefits of Introduction】 - Improves permeability to the skin, making it easier to deliver ingredients. - High stability in aqueous solutions makes it suitable for cosmetic formulations. - Even at low concentrations, it is expected to convert to NAD+ within cells, supporting the expression of effects.

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