[Event] Announcement of Participation in the Food Development Expo 2022

Excellent anti-glycation effect! This is a food ingredient containing "hydroxy isoflavones" with anti-aging, anti-glycation, anti-diabetic, and anti-obesity effects.

"UNIFINE" is a fermented isoflavone anti-glycation ingredient that converts soybean-derived isoflavones into hydroxyl isoflavones through fermentation. Hydroxyl isoflavones not only have significantly greater antioxidant power than pre-fermentation isoflavones but also possess the ability to suppress the generation of glycation reaction products and promote their decomposition. This ingredient is suitable for product planning aimed at anti-aging, glycation countermeasures, and anti-metabolic syndrome measures. 【Features】 - A fermented ingredient made from soybean extract containing isoflavones, fermented with koji mold. - An anti-glycation ingredient with hydroxyl isoflavones as the active component (Patent No. 5318339). - Suppression and decomposition of glycation reaction products (CML, 3DG, pentosidine). - Anti-diabetic (improvement of glucose tolerance) and anti-obesity (suppression of fat accumulation) effects (patent pending). - Anti-glycation effects in the body through oral intake, suppression of carbonyl protein generation, and skin beautifying effects. - Effectiveness in suppressing glycation-related hair loss (patent pending). - Antioxidant capacity (DPPH, OH radical scavenging ability). - Cosmetic ingredient "UNIFINE-CO" is also available. For more details, please refer to the catalog or feel free to contact us.

• Organic Natural Materials

Functional food ingredient containing rose petal polyphenols for combating metabolic syndrome!

"ROSE CRYSTA-70" (High Concentration Rose Polyphenol) is a functional ingredient concentrated from polyphenols extracted from rose petal extract. It is an extract powder that is extracted, concentrated, and spray-dried from wild rose petals, containing over 70% polyphenols derived from rose petals. It has effects such as suppressing fat absorption after meals, inhibiting blood sugar level increases, improving skin elasticity, and whitening effects. [Features] ■ Suppresses fat absorption during meals ■ Works to inhibit blood sugar level increases after meals ■ Improves indicators of metabolic syndrome ■ Powerful antioxidant activity from polyphenols [Consumer Ingredient Introduction Page] https://toyohakko-healthcare.com/rose_crysta70/ For more details, please refer to the catalog or feel free to contact us.

• Organic Natural Materials

Functional food ingredient containing rose petal polyphenols for combating metabolic syndrome!

"ROSE CRYSTA" (Rose Petal Extract) is an anti-allergy material standardized with the active ingredient eugenol. It is an extract powder obtained from the petals of wild rose species, spray-dried, using approximately 220,000 rose petals for every 1 kg of this product. By inhibiting the binding of IgE to IgE receptors and suppressing the release of histamine, it makes allergy symptoms less likely to occur. It can also be used in combination with other ingredients that have different mechanisms, such as red clover extract and lactic acid bacteria. [Features] - Material suitable for Type I allergies - Confirmed IgE-IgE receptor inhibitory activity (Patent No. 4097300) - Suppresses the release of histamine, alleviating sneezing, runny nose, and itching - Expected to be effective not only during pollen seasons but also for perennial allergy symptoms - Whitening and skin beautifying effects For more details, please refer to the catalog or feel free to contact us.

• Organic Natural Materials

Plant-derived beauty ingredients comparable to placenta for anti-wrinkle and firmness improvement, improving various symptoms of menopause, a common concern for women.

It is a plant-derived beauty ingredient fermented with natto bacteria from rice bran extract and soybean extract. It promotes the production of human type I collagen and hyaluronic acid in fibroblasts. 【Features】 ■ A plant-derived beauty ingredient comparable to placenta for anti-wrinkle and firmness improvement. ■ In human monitor tests, skin hydration and elasticity improvements have been confirmed, providing a noticeable effect on skin condition. (Patent No. 6332941) ■ Improves cardiovascular diseases, coldness, and swelling (improves blood flow and blood pressure). ■ Improves various symptoms of menopausal disorders (patent pending). ■ It has been shown to have a stronger acetaldehyde metabolism effect than curcumin, the active ingredient in turmeric, making it less likely to cause hangovers. ■ Maintains power during exercise (anti-fatigue effect). Effect of suppressing the accumulation of lactic acid, a fatigue substance, after exercise. Patent No. 5855375 ■ Reduces oxidative stress in the body. ■ Reduces triglycerides in blood vessels. ■ Available as a cosmetic ingredient. 【Explanation Video】 https://youtu.be/fv16LGEJjtY 【For General Consumers】 https://toyohakko-healthcare.com/celabio_f/

• Organic Natural Materials

Activates natural immunity, promotes skin metabolism, and also has beauty effects! Further immune enhancement can be expected when used in combination with lactic acid bacteria.

"IMMUNOL" is a material that has been fermented and powdered using plant-derived ingredients from acetic acid bacteria isolated from fruit (persimmons). The active component, glycolipid (lipopolysaccharide: LPS), is a structural component of the cell walls of Gram-negative bacteria, including acetic acid bacteria. It is expected to normalize the immune balance in the body and promote natural healing and skin metabolism. [Features] ■ Activates natural immunity ■ Activates macrophages, which are phagocytic cells Further activation of macrophages can be expected when used in combination with lactic acid bacteria. ■ Has the effect of suppressing IgE antibody-dependent allergies (Type I allergies), particularly expected to alleviate symptoms of hay fever and atopic dermatitis. ■ Promotes proliferation in fibroblasts and enhances hyaluronic acid production ■ We also offer a cosmetic ingredient "IMMUNOL-CO." For more details, please refer to the catalog or feel free to contact us.

• Organic Natural Materials

Increase beneficial bacteria and improve intestinal flora! Deodorizing material derived from fermented extracts of plants and grains.

"SENSEPUR" is a deodorizing material for bowel movements extracted through fermentation using biotechnology from plants and grains. It normalizes the intestinal flora, promotes intestinal movement, addresses constipation, positively affects the skin, normalizes nutrient absorption, and suppresses unpleasant odors through fermented extracts of rice bran and tree extracts (yucca extract, kiraya extract). Additionally, both yucca and kiraya contain a high amount of saponins, which are believed to exert direct deodorizing effects by capturing volatile oil-soluble components. 【Features】 ■ Suppression of odor intensity, odor concentration, and unpleasant odors ■ Refreshes the stomach and skin ■ Etiquette material for bad breath, body odor, and bowel odor ■ Good stability, can be blended in various forms ■ Balances intestinal flora 【Consumer Ingredient Introduction Page】 https://toyohakko-healthcare.com/sensepur/ *For more details, please refer to the catalog or feel free to contact us.

• Organic Natural Materials

Enhanced effects through the mixing and extraction of two types of seaweed! Antitumor materials containing fucoidan and others.

"SOLWEED" is a health food made by mixing and extracting "mekabu" and the Canadian seaweed "ascophyllum," which is then spray-dried as is. Mekabu and ascophyllum contain useful minerals and are known for their blood coagulation prevention effects, cholesterol-lowering effects, as well as immune activation and anti-tumor effects due to components like fucoidan. This product has excellent heat stability, making it ideal for drinks that require heat sterilization and for high-temperature sterilized retort processing. 【Features】 ■ Excellent heat stability ■ Blood coagulation prevention effects, cholesterol-lowering effects ■ Immune activation and anti-tumor effects due to components like fucoidan ■ Inhibition of Salmonella binding to macrophages ■ Suppression of Helicobacter pylori proliferation For more details, please refer to the catalog or feel free to contact us.

• Organic Natural Materials

"ROBO TUBE" is a microtube with 1D/2D code that achieves excellent sealing and fitting properties. By integrating polypropylene and thermoplastic elastomer through one-shot molding, it realizes superior sealing and fitting. Compared to conventional microtubes, the opening and closing of the cap is very smooth, reducing the stress of cap operation. 【Features】 ■ The opening and closing of the cap is very smooth compared to conventional microtubes ■ Reduces the stress of cap operation ■ Innovative two-color molding of polypropylene and thermoplastic elastomer ■ Achieves excellent sealing and fitting properties ■ High compatibility with lab automation *For more details, please download the PDF or feel free to contact us.

We have unveiled two new products. 【Downflow Dust Collector (DFPRE Large Series)】 A packaged dust collector that combines productivity and practicality. It uses downward airflow to reduce filter load, leading to lower maintenance costs. Suitable for various industrial sectors including metal and machining, industrial applications, and waste recycling. 【Workstation Dust Collector (DBE Series)】 A dust collector integrated with a workstation, saving space. Recommended for dust control in manufacturing processes such as grinding, polishing, cutting, and finishing. It accommodates long and heavy workpieces. Applicable in various manufacturing processes including metalworking, aircraft parts manufacturing, automotive manufacturing, and industrial machinery manufacturing. For more details, please refer to the downloadable catalog or contact us. (C) Nippon Donaldson, Ltd. All rights reserved.

We would like to introduce 'Slim 4' handled by FCR & Bio Co., Ltd. This product is a jacket tube with a rack lid lock and anti-rotation function (compatible capacity 4.1ml). It is autoclavable and suitable for DMSO and vapor phase of liquid nitrogen. Additionally, it features a screw cap that does not use O-rings, packing, or gaskets. 【Features】 ■ Polypropylene ■ Autoclavable ■ DMSO compatible ■ Suitable for vapor phase of liquid nitrogen *For more details, please download the PDF or feel free to contact us.

We will hold a thick plate solution event. We will propose a highly efficient automated operation for the entire factory, including cutting with the newly unveiled fiber laser machine, automatic transportation, and bending processing. This event will allow you to experience the latest machines and processing, so we encourage you to attend. 【Event Schedule】 November 21 (Friday) and 22 (Saturday), 2025, from 13:00 to 14:00 *Please note that the capacity for November 21 (Friday) is nearing full, so we recommend attending on November 22 (Saturday). If we reach capacity, we may have to decline participation. Please apply early. 【Event Location】 Amada Global Innovation Center (200 Ishida, Isehara City, Kanagawa Prefecture) 【Event Content】 Part 1: Product Introduction Seminar Part 2: Live Demonstration

Cataracts are a common condition that significantly impacts daily life, causing many people to struggle. However, cataract surgery can restore or greatly improve patients' vision. KNF vacuum pumps are an essential component of the medical devices used for such precise surgeries. KNF offers a diverse lineup of diaphragm pumps for cataract surgery. For debris removal, the N 813 is a strong option. It achieves a maximum vacuum of 0.5 mbar (absolute), a maximum flow rate of 13 l/min, and a maximum pressure of 0.3 bar (relative). The N 813 provides stable, reliable performance with a compact design. It can be equipped with a customizable state-of-the-art BLDC motor that enables precise flow control. Its configuration and motor allow for low-speed operation, ensuring the necessary flow rate and vacuum for cataract surgery while reducing noise and vibration.