Agilent Japan Pharmaceutical Society 143rd Annual Meeting Luncheon Seminar: Challenges in Nitrosamine Analysis and Agilent's LC/MS & GC/MS Solutions

Reliable detection and quantification of nitrosamines and mutagenic impurities.

Due to the presence of unacceptable levels of mutagenic nitrosamine impurities, several pharmaceuticals have recently been recalled. To accurately detect and quantify trace amounts of mutagenic impurities in pharmaceuticals, Agilent offers relevant GC/MS, LC/MS, and high-throughput MS-based analytical techniques. <Challenges in Nitrosamine Analysis> 1. Introducing mass spectrometers requires meeting regulatory requirements, which can be cumbersome. 2. There are many target substances, making it difficult to choose which method/device to use for GC/MS or LC/MS. 3. Due to the high cost of the equipment, results that justify the expense are expected (in terms of cost, operation, speed from introduction to startup, and decisions on outsourcing). 4. It is challenging to foresee whether the risk assessment can be completed by the deadline. <Solutions for Nitrosamine Analysis> Agilent's application guide provides various validated methods from sample preparation to measurement analysis, enabling quick setup and support from introduction to operation. Additionally, regulatory compliance, including data integrity, is achievable.

• Chemicals
• Testing Equipment and Devices
• Analytical Equipment and Devices

Explanation of the measurement of nitrosamine impurities using the high-resolution "Agilent 6546 LC/Q-TOF"!

Angiotensin II receptor blockers (ARBs) are widely used in the treatment of hypertension and heart failure. Recently, it has been found that some ARBs contain carcinogenic nitrosamine impurities, resulting in the recall of many products. Consequently, there is a demand for analytical methods capable of detecting these problematic nitrosamine impurities. This application note describes a high-sensitivity and high-resolution LC/MS/MS method using the "Agilent 6546 LC/Q-TOF" for the detection and quantification of six types of nitrosamines specified by the US FDA, as well as a simultaneous detection method for eleven types of nitrosamine impurities. [Contents] ■ Introduction ■ Experimental Methods ■ Results and Discussion ■ Conclusion ■ References ■ Acknowledgments *For more details, please refer to the PDF document or feel free to contact us.

• Analytical Equipment and Devices

We will be exhibiting at the "43rd Nano Testing Symposium (NANOTS2023)" held at the Senri Life Science Center in Toyonaka City, Osaka Prefecture! We will be introducing our latest analytical technology services, so please stop by! We sincerely look forward to your visit.

We would like to extend our heartfelt congratulations on the continued prosperity of your esteemed company. Our company will be exhibiting at the following trade show, where we will introduce a number of products, including our new product, the Pillow Packaging Full Air Tightness Inspection Machine MSQ-2003. We sincerely apologize for the inconvenience during your busy schedule, but we would like to invite you to visit us at this opportunity. 【 Exhibition Name 】 JAPAN PACK 2025 Japan Packaging Industry Exhibition https://www.japanpack.jp/ 【 Dates 】 October 7 (Tuesday) to October 10 (Friday), 2025 *4 days 10:00 AM to 5:00 PM 【 Venue / Booth Number 】 Tokyo Big Sight / East Hall 8, Booth 8-505

We will be exhibiting at JAPAN PACK 2025 (Japan Packaging Industry Exhibition)! Please be sure to visit us. [Exhibited Products] Pineapple suction project Live demonstration of a collaborative robot hand 5kg dual-sided gripper Comparison of compressed air ejectors with other companies 【Gripper Sale】 We will be selling the following two products at a discounted price at our booth. Please inquire about the special price at the venue. ■ 'KENOS Gripper KVGL.400.100, N214.FR6.S2' URL: https://www.youtube.com/watch?v=HsNRwrDtjW0 ■ 'Collaborative Robot Hand KCS.Q110.N301.110.FR6.SX422.V1.X.X' URL: https://www.youtube.com/watch?v=GFKg3blZzdQ These products are ideal not only for actual applications but also for use as test machines. How about taking this opportunity?

"We want to digitize paper documents within the company, but we don't know which service to choose" and "We can't keep up with the changes in the Electronic Bookkeeping Law and the legal revisions in the construction and manufacturing industries." For those individuals, we have an announcement. The electronic contract and document management service, paperlogic, will be exhibiting at the event 'Serious DX & AI Strategy 2025' held on October 15 (Wednesday) at Sogo Yokohama. This time, there will also be a seminar led by our representative, certified public accountant and tax accountant Koichi Yokoyama. We will also be conducting product demonstrations at the exhibition, so please come and visit us. ● Our representative, Yokoyama, will also give a lecture! Luxurious Seminar At 'Serious DX & AI Strategy 2025', Koichi Yokoyama, the representative of Paperlogic Inc., will be speaking in [Seminar B Course]. On that day, he will introduce key points of laws including the revised Construction Industry Law, which will be enforced by December 2025, and related document management, from the perspective of a certified public accountant and tax accountant. Additionally, there will be seminars that are useful for utilizing AI and DX. For more details, please check the event website.

This is the announcement for the second part of the Op-Amp Classroom Series, "Op-Amp Classroom - DC Characteristics and AC Characteristics." We will explain the DC and AC electrical characteristics as the basics of op-amps. Since we will start with an introduction to fundamental functions, those who have not participated in Op-Amp Classroom 1 are also welcome to join. The difficulty level is beginner to intermediate, so whether you are new to analog ICs or have specific issues, we encourage you to participate! ● Target Audience - Engineers who are new to analog circuit design - Board evaluators and test engineers - Those who are newly responsible for component purchasing ● Agenda 1. Electrical Characteristics of Op-Amps (DC Characteristics) - Input offset voltage / Input bias current - Common-mode input voltage range and input stage configuration - Output inversion of dual-supply op-amps - What are sink/source currents? - Crossover distortion 2. Electrical Characteristics of Op-Amps (AC Characteristics) - What is slew rate? - What is gain-bandwidth product (GBW)? 3. Oscillation of Op-Amps We look forward to your participation!