Agilent Japan Pharmaceutical Society 143rd Annual Meeting Luncheon Seminar: Challenges in Nitrosamine Analysis and Agilent's LC/MS & GC/MS Solutions

Reliable detection and quantification of nitrosamines and mutagenic impurities.

Due to the presence of unacceptable levels of mutagenic nitrosamine impurities, several pharmaceuticals have recently been recalled. To accurately detect and quantify trace amounts of mutagenic impurities in pharmaceuticals, Agilent offers relevant GC/MS, LC/MS, and high-throughput MS-based analytical techniques. <Challenges in Nitrosamine Analysis> 1. Introducing mass spectrometers requires meeting regulatory requirements, which can be cumbersome. 2. There are many target substances, making it difficult to choose which method/device to use for GC/MS or LC/MS. 3. Due to the high cost of the equipment, results that justify the expense are expected (in terms of cost, operation, speed from introduction to startup, and decisions on outsourcing). 4. It is challenging to foresee whether the risk assessment can be completed by the deadline. <Solutions for Nitrosamine Analysis> Agilent's application guide provides various validated methods from sample preparation to measurement analysis, enabling quick setup and support from introduction to operation. Additionally, regulatory compliance, including data integrity, is achievable.

• Chemicals
• Testing Equipment and Devices
• Analytical Equipment and Devices

Explanation of the measurement of nitrosamine impurities using the high-resolution "Agilent 6546 LC/Q-TOF"!

Angiotensin II receptor blockers (ARBs) are widely used in the treatment of hypertension and heart failure. Recently, it has been found that some ARBs contain carcinogenic nitrosamine impurities, resulting in the recall of many products. Consequently, there is a demand for analytical methods capable of detecting these problematic nitrosamine impurities. This application note describes a high-sensitivity and high-resolution LC/MS/MS method using the "Agilent 6546 LC/Q-TOF" for the detection and quantification of six types of nitrosamines specified by the US FDA, as well as a simultaneous detection method for eleven types of nitrosamine impurities. [Contents] ■ Introduction ■ Experimental Methods ■ Results and Discussion ■ Conclusion ■ References ■ Acknowledgments *For more details, please refer to the PDF document or feel free to contact us.

• Analytical Equipment and Devices

[Lecturer] Takeshi Ichimura President and CEO, Energy Pool Japan Co., Ltd. Committee Memberships as of August 2025 - Study Group on Next-Generation Decentralized Power Systems, Agency for Natural Resources and Energy - ERAB Study Group, Agency for Natural Resources and Energy - Study Group on the Nature of Simultaneous Markets, Agency for Natural Resources and Energy - Committee on Adjustment Power and Supply-Demand Balance Evaluation, Electricity Wide Area Operation Promotion Organization - Subcommittee on Supply-Demand Adjustment Market, Electricity Wide Area Operation Promotion Organization - Study Group on Future Power Supply-Demand Scenarios, Electricity Wide Area Operation Promotion Organization - Working Group on Future Supply-Demand Scenarios (Load Curve, DAC) [Lecture Items] October 28 (Tuesday) 13:00 - 15:00 1st Session: Learning About the Electricity Business and Capacity Market from Scratch 1. Fundamental Discussion: What is Power System Reform? 2. Learning About the Capacity Market from Scratch 3. Summary 4. Q&A November 7 (Friday) 15:00 - 17:00 2nd Session: Learning About the Electricity Business and Supply-Demand Adjustment Market & Simultaneous Market from Scratch 1. Fundamental Discussion: What is Power System Reform? (Review of the 1st Session) 2. Learning About the Supply-Demand Adjustment Market from Scratch 3. Summary 4. Q&A

[Lecturer] Mitsubishi Research Institute, Inc. Policy and Economic Center Chief Researcher Jiro Furuki [Key Lecture Content] There is a demand for a transition from the traditional economy of "making, using, and discarding" in large quantities (linear economy) to a "circular economy" that reuses resources as much as possible without consuming them. While the importance of this shift is becoming understood, many companies hesitate to take actual action due to concerns such as "Will it be costly?" and "Will it negatively impact our current business?" In this lecture, we will introduce the significance and effects of the circular economy, trends in domestic and international policies, and the initiatives that companies are currently required to undertake, along with ideas for policies and support that can facilitate these efforts. [Lecture Items] 1. Significance and effects of transitioning to a circular economy 2. Domestic and international trends related to the transition to a circular economy 3. Two key points for achieving an autonomous circular economy 4. Close Flow: Recommendations for expanding the use of recycled materials 5. Slow: Recommendations for transitioning to a business model for CE commerce 6. Summary 7. Q&A / Business card exchange

[Speaker] Kazuki Miyamoto, Representative/Analyst of VentureClef, USA [Key Lecture Content] The competition for the development of "AGI agents" and "AGI humanoid robots" is intensifying. AGI agents are models with human-level skills that autonomously perform tasks on behalf of employees. AGI agents are based on next-generation foundation models, with enhanced reasoning capabilities and significantly evolved skills in using tools. The killer application of AGI is the AGI agent, which demonstrates human-level job capabilities in digital spaces. The foundation model has merged with the "world model" to create "physical AI." Physical AI will be a breakthrough in robot development. There is intense technological innovation in AGI humanoid robots, which acquire the ability to perform human labor in physical spaces. The competition for the development of AGI humanoid robots is intensifying in the United States and China, creating a massive market. The Trump administration supports the development of AGI humanoid robots and is implementing "reshoring" policies to bring manufacturing back to the United States.

Are you ready to escape the hell of manual data entry from FAX and phone orders? 'Processing 20 orders a day takes over 2 hours' 'Excel data entry work accounts for 40% of daily operations' To all manufacturing companies struggling with such inefficient order processing. In this seminar, we will introduce specific methods for optimizing order operations in three stages, based on case studies of companies that have achieved annual cost reductions of 7.2 million yen and improved error rates by 78%. You will learn practical know-how to eliminate the 'manual entry hell' through gradual digitization, from automatic data conversion of FAX using OCR technology to building a web order system. This seminar will also offer individual consultations tailored to your company's challenges. In this seminar, we will introduce the following solutions: - EC-Connect+ - ASTERIA Warp

**Seminar Overview** "Generative AI" is gaining attention as a method for improving business efficiency and utilizing internal digital transformation (DX). However, its effectiveness can be influenced by the literacy of the employees using it, which may, in turn, increase the burden of work. In this seminar, we will discuss the current challenges of generative AI while providing examples of how it can be used to enhance business efficiency. We will also explain how to utilize generative AI in a way that achieves efficiency without being affected by the user's skills. We hope this will serve as a reference for considering the use of generative AI.