Elucidating a new binding pattern indicated by guanine-rich DNA - Discovery of a new structure involved in the interaction with insulin, with expectations for drug development applications and the development of novel insulin sensors.

A collaborative research group led by Professor Kazunori Ikebukuro and Professor Yasumoto Nakazawa from the Graduate School of Engineering at Tokyo University of Agriculture and Technology, along with Naoya Iwano from Toray Research Center, Yasushi Ohyama from Japan Spectroscopic Co., Ltd., and Professor Hiroshi Hayashida from the University of North Carolina at Chapel Hill, has revealed for the first time that guanine-rich DNA, known to be involved in various biological functions, can specifically bind to proteins without forming guanine quadruplex structures (G4 structures). In particular, the study focused on the guanine-rich insulin aptamer "IGA3" and analyzed in detail how it interacts with insulin. Previously, IGA3 was thought to bind to insulin by forming a G4 structure; however, this research discovered that it does not bind in the G4 structure but instead forms a new structure to bind to insulin.
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