We have published technical documentation on the purification of bispecific antibodies.

Selection of chromatography suitable for the separation of aggregated impurities related to antibodies.

During the production of bispecific antibodies (BsAb), various impurities such as mispaired antibodies, aggregates, incomplete antibodies, and fragment antibodies are often generated. Therefore, in the downstream purification process of BsAb, it is important to effectively separate and remove these impurities derived from various products and process-related impurities using chromatography. This report presents the separation modes of chromatography used in the isolation and purification of BsAb that have been previously reported, along with the corresponding packing materials and separation conditions.

• Chromatographic resins and packing materials

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