Nitrosamine Analysis Webinar Part 2

Explanation of the measurement of nitrosamine impurities using the high-resolution "Agilent 6546 LC/Q-TOF"!

Angiotensin II receptor blockers (ARBs) are widely used in the treatment of hypertension and heart failure. Recently, it has been found that some ARBs contain carcinogenic nitrosamine impurities, resulting in the recall of many products. Consequently, there is a demand for analytical methods capable of detecting these problematic nitrosamine impurities. This application note describes a high-sensitivity and high-resolution LC/MS/MS method using the "Agilent 6546 LC/Q-TOF" for the detection and quantification of six types of nitrosamines specified by the US FDA, as well as a simultaneous detection method for eleven types of nitrosamine impurities. [Contents] ■ Introduction ■ Experimental Methods ■ Results and Discussion ■ Conclusion ■ References ■ Acknowledgments *For more details, please refer to the PDF document or feel free to contact us.

• Analytical Equipment and Devices

Reliable detection and quantification of nitrosamines and mutagenic impurities.

Due to the presence of unacceptable levels of mutagenic nitrosamine impurities, several pharmaceuticals have recently been recalled. To accurately detect and quantify trace amounts of mutagenic impurities in pharmaceuticals, Agilent offers relevant GC/MS, LC/MS, and high-throughput MS-based analytical techniques. <Challenges in Nitrosamine Analysis> 1. Introducing mass spectrometers requires meeting regulatory requirements, which can be cumbersome. 2. There are many target substances, making it difficult to choose which method/device to use for GC/MS or LC/MS. 3. Due to the high cost of the equipment, results that justify the expense are expected (in terms of cost, operation, speed from introduction to startup, and decisions on outsourcing). 4. It is challenging to foresee whether the risk assessment can be completed by the deadline. <Solutions for Nitrosamine Analysis> Agilent's application guide provides various validated methods from sample preparation to measurement analysis, enabling quick setup and support from introduction to operation. Additionally, regulatory compliance, including data integrity, is achievable.

• Chemicals
• Testing Equipment and Devices
• Analytical Equipment and Devices

From February 11 (Wednesday) to February 13 (Friday), Mikasa Trading Co., Ltd. will sponsor the technology conference "JANOG57 Meeting in Osaka" held at the Congre Convention Center. This event provides an open platform for field engineers to freely discuss and share the latest network technologies, practical operational know-how, and case studies of failures. This time, we will be exhibiting a booth in collaboration with Western Digital Marketing LLC, showcasing innovative storage solutions such as the "Ultrastar Data60" and HDDs with a maximum capacity of 30TB. The Ultrastar Data60 is recognized for its ability to efficiently accommodate up to 60 high-quality HDDs while achieving large capacity, low cost, and space-saving design. Additionally, we will display mobile label printers made by Brady Japan at our booth. You will have the opportunity to see products that are actively used in infrastructure development and data management up close. Don't miss this chance to experience the technologies that support the future! We look forward to seeing you at the venue.

[Key Lecture Content] 1. Where is railway town development headed? ~Understanding next-generation urban development through TOD and smart cities~ SOMPO Institute Plus Co., Ltd. Senior Researcher, Public Policy Research Department, Mariko Miyamoto 1. Trends in compact town development 2. What is TOD (Transit-Oriented Development)? 3. Why TOD now? 4. Next-generation urban development through TOD and smart cities 5. Q&A / Business card exchange 2. Latest trends in TOD at TAKANAWA GATEWAY CITY General Incorporated Association Takanawa Gateway Area Management Executive Director, Yoshinari Amano 1. Collaborative town development centered around the Greater Shinagawa area stations 2. Takanawa Gateway What is the "Ekima-chi Smart City Concept"? 3. Collaboration between urban and railway OS ~Concept of data governance~ 4. Sustainable + mobility creating regional public transportation 5. Summary 6. Q&A / Business card exchange

This is a practical monetization seminar that clearly explains the process of creating acrylic keychains and how to generate profits, with the opportunity to ask questions on the spot. You will also be able to see the movements of the "BD-8" and laser processing machines at the venue. It's perfect for those who want to start a manufacturing business!

Olink Explore HT is a next-generation proteomics analysis platform that enables the high-sensitivity and high-throughput measurement of numerous proteins from small sample volumes. In this webinar, we will explain the technical features and utilization points of Olink Explore HT and the new product Reveal, based on our analysis experience using actual BioBank Japan samples. We will also introduce the differences from other platforms such as SomaScan and Illumina Protein Prep, from the perspectives of analysis design and data characteristics. This content will provide practical insights for researchers considering options for proteomics analysis in large cohort studies and biomarker discovery. Speaker: Dr. Akinori Kanai (Associate Professor, Center for Life Data Science, Graduate School of Frontier Sciences, The University of Tokyo)

In this seminar, we will break down "DX" into five elements in relation to the concept of innovation and explain them with examples. The aim is to deepen the understanding of "DX" itself and clarify what steps should be taken first. Additionally, we will introduce the approach of "suitable personnel in suitable places ERP" as a way to select the foundation for promoting "DX." <Program> - Introduction - The lagging DX in manufacturing and how to succeed in the new era - The choice of "suitable personnel in suitable places" ERP as a foundation for strengthening competitiveness <Recommended for> - Those who are exploring what steps to take towards DX - Business owners, managers in the manufacturing industry, and those responsible for management innovation - System personnel interested in the future of core systems *Applications from competing companies may be declined.