We have published a case study on the detection of off-target effects in knock-in during genome editing.

We will introduce examples of off-target detection in knock-in during genome editing!

We would like to introduce a case study of our random integration analysis service using the RAIS method. For a knock-in mouse created using CRISPR/Cas, we attempted to detect the knock-in efficiency and off-target sites by combining the RAIS method with NGS. It was suggested that the donor DNA used for the knock-in was inserted not only into the intended chromosome 9 (chr9) but also into another chromosome. 【Random Integration Analysis Service using the RAIS Method Contents】 ■ Sanger Sequencing Plan ■ Next Generation Sequencing (NGS) Plan *For more details, please refer to the PDF document or feel free to contact us.

• Contract Analysis
• Contract Analysis
• Analysis Services

On September 11, 2025, AC Tasarim, a cable blade manufacturer, and our company signed a sales agency agreement for Japan. This was also announced in the company's press release and on social media. Founded in Turkey in 2003, AC Tasarim manufactures flexible EMI cable shields (copper braid), polyester braid, meta-aramid braid (Nomex cable sleeves), flat copper braid busbars/ground braids, all AA59569-coded copper braids, and released AeroBraid in 2025, the world's lightest EMI braid. All manufactured copper braids are certified to military standards. AC Tasarim products hold key certifications including VDE/VG certification, German Federal Armed Forces certification, NATO NSN coding, AS9100 quality certification, and JOSCAR certification. Cable braids and EMI shielding products, essential for wire harnesses in the aerospace and defense industries, are becoming increasingly difficult to source as demand rises. TC Tasarim products are stocked by manufacturers and distributors to ensure quick response times.

The "CCS2" is a ceiling-mounted vehicle counting sensor that employs an infrared reflection method. It can detect vehicles in both directions with just one unit, accurately counting vehicles even during traffic jams or when vehicles pass each other. Additionally, this product can be used not only for vehicle counting but also as a sensor for departure warnings. Furthermore, by using a separately sold dedicated remote control, it is easy to reset the sensor alone, switch the counting direction, and change the patterns of the departure warning timer. 【Features】 ■ Angle adjustment is possible up to ±5° ■ Can be installed in locations with high ceilings up to 4m ■ Detection area consists of 40 spots, allowing for wide-range detection ■ The display LEDs are color-coded by direction, making operation confirmation easy.

Many people may have questions like, "What can be done with IoT?" and "What is needed?" upon hearing the term IoT. Through digital communication, it is possible to obtain various information such as flow sensors, valves, circuit boards, and abnormal monitoring that were not accessible with traditional analog control. For example, by monitoring the valve opening, one can detect blockages in the equipment and identify leaks from cumulative flow. This information directly contributes to reducing downtime and improving quality through continuous long-term monitoring and knowledge-based management. Compatible models include those with digital communication via RS485, in addition to traditional analog controls like 0-5VDC and 4-20mA. (Older models such as the 58xxS, MfxxS series, SLA58xxS, and SLAMfxxS series). Even older models that do not support digital communication can be upgraded to the latest mass flow models, enabling digital communication. The dimensions between new and old models are the same, and no wiring changes are necessary. Additionally, we can provide control boxes for data collection from mass flow. This enables a "visualization" of small IoT without making large changes to the equipment.

Model SLA5850/SLA5851/SLA5853/SLA5860/SLA5861/SLA5863 "With just one unit, you can use 14 types of pressure and flow rates in a single process." Imagine such a mass flow controller platform. Moreover, it features excellent reproducibility, precision, and repeatability. This is the evolved simple performance of the SLA5800 series mass flow controllers/meters. The SLA5800 series boasts high accuracy, zero point stability, and repeatability that are characteristic of Brooks Instrument, a leader in mass flow measurement and control technology. Equipped with configurable advanced multi-gas/multi-range capabilities, it offers superior zero drift specifications compared to competing products while demonstrating long-term maintenance of factory calibration and accuracy.

Model SLAMf50 / SLAMf51 / SLAMf53 / SLAMf60 / SLAMf61 / SLAMf63 / SLAMf64 "Durability to withstand harsh environments! Achieving excellent precision with precise mass flow control" Whether indoors or outdoors, in environments with dust or places that handle water, the 'SLAMf series' elastomer seal thermal mass flow controllers/meters provide proven high precision and long-term stability unique to the "SLA5800 family." Applications ■ Pilot plants for petrochemical and chemical gases ■ Life science bioreactors ■ Blanketing in food processing