We have published a case study on the detection of off-target effects in knock-in during genome editing.

We will introduce examples of off-target detection in knock-in during genome editing!

We would like to introduce a case study of our random integration analysis service using the RAIS method. For a knock-in mouse created using CRISPR/Cas, we attempted to detect the knock-in efficiency and off-target sites by combining the RAIS method with NGS. It was suggested that the donor DNA used for the knock-in was inserted not only into the intended chromosome 9 (chr9) but also into another chromosome. 【Random Integration Analysis Service using the RAIS Method Contents】 ■ Sanger Sequencing Plan ■ Next Generation Sequencing (NGS) Plan *For more details, please refer to the PDF document or feel free to contact us.

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To customers considering the introduction of vehicle detection sensors for parking lot construction, design, and management: Are you facing any issues with the challenges you currently have or selecting the right sensors for parking lot management? Hotron offers free materials that explain how to utilize vehicle detection sensors and the benefits of their introduction! ▽ Here is the lineup of materials ◉ Basic Guide to Vehicle Detection Sensors This guide focuses on the challenges and solutions in parking lot operations, introducing the overview of vehicle detection sensors. ◉ Key Points for Introducing Vehicle Detection Sensors This material discusses the benefits of introduction based on installation locations and specific challenges. ◉ Case Studies of Vehicle Detection Sensor Implementation This document introduces the challenges before implementation and the results after introduction. For more details, please download from our website and check it out. https://www.hotron.co.jp/download/

The "24 Tissue Tubes 3.0ml Type" features a wide inner diameter of 13.4mm at the mouth, a low height of 25.9mm, and a flat bottom design, making it easy to insert and remove samples. Each tube is equipped with a 2D code on the bottom, allowing for efficient sample information management by using a 2D scanner to reflect the code in a PC database. Additionally, it is compatible with automated systems due to its SBS format. 【Features】 ■ Easy insertion and removal of samples ■ Particularly suitable for tissue/cell samples measuring 5mm to 7mm ■ Using our dedicated rack for 24 tubes allows for bulk reading of the 2D codes on the tube bottoms ■ Compatible with automated systems due to its SBS format ■ Made of polypropylene, autoclavable, and compatible with DMSO *For more details, please refer to the related links or feel free to contact us.

■Disadvantages of Conventional Antistatic Fluororesin Coatings - Requires high-temperature firing (around 400°C) - Applicable only to metals - Limited color options - Low mechanical strength ■Features of Safron LF+ - Can be processed at low temperatures (below 100°C) - Applicable to metals and resins - Color variations available - High friction coefficient and mechanical strength - Antistatic performance is equivalent to conventional Safron For more details, please check the product site.

● This is a leak testing device for small electronic components that does not use fluorinated inert liquids (PFAS-free). ● There is no longer a need for unstable visual confirmation through liquid immersion testing. It adopts a quantitative testing method that allows for stable pressure leak testing. ● It is a tabletop leak testing device specifically for gross leaks, with accuracy equal to or greater than that of liquid immersion testing. ● The detectable range is approximately 1×10⁻² Pa·m³/s to 1×10⁻⁶ Pa·m³/s (varies depending on the target product). ● It is suitable for sealed structures ranging from a few millimeters to a maximum of 80 × 70 mm. Please feel free to contact us for more information!

The "Mechanical Stitching Method" by Nichinichisui Road Machinery Co., Ltd. is a new technique that allows for the repair of metal cracks without the application of heat. By using special bolts and reinforcement plates, cracks are physically removed, and repairs are made without causing any thermal impact to the base material. Repairs can be carried out in environments where open flames cannot be used. Since no heat is applied, the disassembly of equipment is minimized. ◎ For more details, please contact us. ◎ If a detailed technical explanation is needed, please contact us.