[New Product] Expandable Label-Free Real-Time Biomolecular Interaction Analysis System Octet R Series

High-throughput binding affinity measurement using BLI and Dip and Read assays. Accelerates kinetics analysis, quantification, and characterization.

Octet Systems is an automated assay system that enables label-free, real-time measurement and analysis of interactions between biomolecules using Bio-Layer Interferometry (BLI) and Dip and Read assays. It eliminates the bottlenecks of traditional SPR methods, achieving high throughput, compatibility with diverse samples, and ease of use. The Octet system offers five models, allowing for the selection of the optimal system based on the number of samples, applications, and budget. 【Features】 ■ High-throughput assay method facilitates multi-sample assays and optimization of experimental conditions. ■ Capable of measuring crude samples such as cell lysates in their unrefined state. ■ Allows measurement of low-solubility samples using buffers containing high concentrations of DMSO solutions. ■ No complicated setup, shutdown procedures, or maintenance required. ■ The Dip and Read assay enables the recovery and reuse of samples after measurement. *For more details, please refer to the related catalog or feel free to contact us.

• Other physicochemical equipment
• Testing Equipment and Devices
• Other inspection equipment and devices

We support researchers worldwide in the study and development of treatments and vaccines for SARS-CoV-2 through the Octet platform.

In January 2020, the genomic sequence of COVID-19 was released, leading to many papers that brought breakthroughs related to the biology, vaccines, and therapeutic development of coronaviruses, featuring data from the Octet system for analyzing biomolecular interactions. The document "Advancing development of coronavirus vaccine and therapeutics," which can be downloaded from the catalog below, presents research papers that elucidate the binding kinetics and affinity, neutralization, cross-blocking, and potency of COVID-19 virus particles using the Octet system. ■ Rapidly screen and select optimal vaccine and therapeutic candidates ■ Ensure research progresses with the best candidates determined based on data *For more details, please refer to the PDF document or feel free to contact us. 【Contact Information】 Sartorius Japan K.K. BioAnalytics Tel: 03-6478-5200 E-mail: ForteBioJP@Sartorius.com

• Other physicochemical equipment

By using tools compliant with GxP and simple operations, we enable productivity improvements in the analysis development and quality control of pharmaceuticals under regulatory environments.

As a regulatory requirement, biopharmaceuticals must be QC tested using methods that are robust and appropriately qualified and validated under GMP conditions. The Octet system for analyzing biomolecular interactions is a reliable system that facilitates method development for in-process testing and lot release testing, and it can be easily transferred to QC. Due to its ease of use and high throughput characteristics, it can achieve up to 40 times the productivity of ELISA and up to 16 times that of SPR equipment in specific GMP applications. ■ The Octet CFR software and FB server functionality maintain secure and traceable electronic records. ■ The IQ/OQ/PQ package guarantees the required conditions and operations. ■ Validation support services for software and biosensors are provided. *For more details, please refer to the PDF materials or feel free to contact us.

• Analytical Equipment and Devices
• Other analyses

We accelerate the entire process from development to manufacturing of biopharmaceuticals, including cell line development, determination of dynamic binding capacity, potency assays, and impurity confirmation tests.

To minimize the manufacturing costs of biopharmaceuticals while maintaining high standards of quality and safety, technologies are being pursued to streamline the drug development workflow and reduce time. Analytical techniques that enhance efficiency while maintaining quality are essential in the development of biopharmaceuticals, from upstream processes such as cell line development to downstream processes including the determination of dynamic binding capacity of purification columns, impurity confirmation tests, and potency assays. The Octet system for analyzing biomolecular interactions meets the required demands with high sensitivity, high precision, and rapid measurement. ■ Screening of samples during cell line development ■ Monitoring through titer measurement in bioreactors ■ Determination of dynamic binding capacity of chromatography columns and characterization of purified products ■ Rapid and highly accurate detection of impurities such as host cell proteins and residual Protein A *For more details, please refer to the PDF document or feel free to contact us.

• Analytical Equipment and Devices

Label-free assay with just a single drop of sample. Enables simple and rapid kinetics analysis, protein quantification and detection, and assay development.

The Octet N1 system is a personal assay system that enables label-free, real-time measurement and analysis of biomolecular interactions using Bio-Layer Interferometry (BLI) and Dip and Read assays. It significantly reduces initial setup costs and allows for simple and rapid kinetics analysis (Ka, Kd, KD), protein detection and quantification, and assay development. 【Features】 ■ Measurement possible with just 4μL of a small sample ■ Ability to measure crude samples such as cell lysates in their unpurified state ■ Label-free assay that minimizes time and cost associated with labeling ■ No complicated setup, shutdown procedures, or maintenance required ■ Compact size that can be installed in a space smaller than A4 size ■ Kinetics analysis possible with reduced initial setup costs *For more details, please refer to the PDF document or feel free to contact us.

• Other physicochemical equipment

We would like to introduce 'Slim 4' handled by FCR & Bio Co., Ltd. This product is a jacket tube with a rack lid lock and anti-rotation function (compatible capacity 4.1ml). It is autoclavable and suitable for DMSO and vapor phase of liquid nitrogen. Additionally, it features a screw cap that does not use O-rings, packing, or gaskets. 【Features】 ■ Polypropylene ■ Autoclavable ■ DMSO compatible ■ Suitable for vapor phase of liquid nitrogen *For more details, please download the PDF or feel free to contact us.

The "Mechanical Stitch Method" by Nichinichisui Road Machinery Co., Ltd. is a new technique that allows for the repair of metal cracks without the application of heat. By using special bolts and reinforcement plates, cracks are physically removed, and repairs are made without causing any thermal impact to the base material. Repairs can be carried out in environments where open flames cannot be used. Since no heat is applied, the disassembly of equipment is minimized. ◎ For more details, please contact us. ◎ If a detailed technical explanation is needed, please contact us.

The "Mechanical Stitching Method" by Nichinichisui Road Machinery Co., Ltd. is a new technique that allows for the repair of metal cracks without the application of heat. By using special bolts and reinforcement plates, cracks are physically removed, and repairs are made without causing any thermal impact on the base material. Repairs can be carried out even in environments where open flames cannot be used. Since no heat is applied, the disassembly of equipment is kept to a minimum. ◎ For more details, please contact us. ◎ If a detailed technical explanation is needed, please contact us.

The "Mechanical Stitching Method" by Nichinichisui Road Machinery Co., Ltd. is a new technique that allows for the repair of metal cracks without the application of heat. By using special bolts and reinforcement plates, cracks are physically removed, and repairs are made without causing any thermal impact to the base material. Repairs can be carried out in environments where open flames cannot be used. Since no heat is applied, the disassembly of equipment is minimized. ◎ For more details, please contact us. ◎ If a detailed technical explanation is needed, please contact us.

Fukuda Co., Ltd., which develops, manufactures, and sells leak testing equipment to inspect airtightness and sealing performance, provides a technical document that clearly explains the methods and theories of airtight testing, titled "Technical Manual." We are offering it as a PDF file. Please take this opportunity to download and view it!