[New Product] Expandable Label-Free Real-Time Biomolecular Interaction Analysis System Octet R Series

High-throughput binding affinity measurement using BLI and Dip and Read assays. Accelerates kinetics analysis, quantification, and characterization.

Octet Systems is an automated assay system that enables label-free, real-time measurement and analysis of interactions between biomolecules using Bio-Layer Interferometry (BLI) and Dip and Read assays. It eliminates the bottlenecks of traditional SPR methods, achieving high throughput, compatibility with diverse samples, and ease of use. The Octet system offers five models, allowing for the selection of the optimal system based on the number of samples, applications, and budget. 【Features】 ■ High-throughput assay method facilitates multi-sample assays and optimization of experimental conditions. ■ Capable of measuring crude samples such as cell lysates in their unrefined state. ■ Allows measurement of low-solubility samples using buffers containing high concentrations of DMSO solutions. ■ No complicated setup, shutdown procedures, or maintenance required. ■ The Dip and Read assay enables the recovery and reuse of samples after measurement. *For more details, please refer to the related catalog or feel free to contact us.

• Other physicochemical equipment
• Testing Equipment and Devices
• Other inspection equipment and devices

We support researchers worldwide in the study and development of treatments and vaccines for SARS-CoV-2 through the Octet platform.

In January 2020, the genomic sequence of COVID-19 was released, leading to many papers that brought breakthroughs related to the biology, vaccines, and therapeutic development of coronaviruses, featuring data from the Octet system for analyzing biomolecular interactions. The document "Advancing development of coronavirus vaccine and therapeutics," which can be downloaded from the catalog below, presents research papers that elucidate the binding kinetics and affinity, neutralization, cross-blocking, and potency of COVID-19 virus particles using the Octet system. ■ Rapidly screen and select optimal vaccine and therapeutic candidates ■ Ensure research progresses with the best candidates determined based on data *For more details, please refer to the PDF document or feel free to contact us. 【Contact Information】 Sartorius Japan K.K. BioAnalytics Tel: 03-6478-5200 E-mail: ForteBioJP@Sartorius.com

• Other physicochemical equipment

By using tools compliant with GxP and simple operations, we enable productivity improvements in the analysis development and quality control of pharmaceuticals under regulatory environments.

As a regulatory requirement, biopharmaceuticals must be QC tested using methods that are robust and appropriately qualified and validated under GMP conditions. The Octet system for analyzing biomolecular interactions is a reliable system that facilitates method development for in-process testing and lot release testing, and it can be easily transferred to QC. Due to its ease of use and high throughput characteristics, it can achieve up to 40 times the productivity of ELISA and up to 16 times that of SPR equipment in specific GMP applications. ■ The Octet CFR software and FB server functionality maintain secure and traceable electronic records. ■ The IQ/OQ/PQ package guarantees the required conditions and operations. ■ Validation support services for software and biosensors are provided. *For more details, please refer to the PDF materials or feel free to contact us.

• Analytical Equipment and Devices
• Other analyses

We accelerate the entire process from development to manufacturing of biopharmaceuticals, including cell line development, determination of dynamic binding capacity, potency assays, and impurity confirmation tests.

To minimize the manufacturing costs of biopharmaceuticals while maintaining high standards of quality and safety, technologies are being pursued to streamline the drug development workflow and reduce time. Analytical techniques that enhance efficiency while maintaining quality are essential in the development of biopharmaceuticals, from upstream processes such as cell line development to downstream processes including the determination of dynamic binding capacity of purification columns, impurity confirmation tests, and potency assays. The Octet system for analyzing biomolecular interactions meets the required demands with high sensitivity, high precision, and rapid measurement. ■ Screening of samples during cell line development ■ Monitoring through titer measurement in bioreactors ■ Determination of dynamic binding capacity of chromatography columns and characterization of purified products ■ Rapid and highly accurate detection of impurities such as host cell proteins and residual Protein A *For more details, please refer to the PDF document or feel free to contact us.

• Analytical Equipment and Devices

Label-free assay with just a single drop of sample. Enables simple and rapid kinetics analysis, protein quantification and detection, and assay development.

The Octet N1 system is a personal assay system that enables label-free, real-time measurement and analysis of biomolecular interactions using Bio-Layer Interferometry (BLI) and Dip and Read assays. It significantly reduces initial setup costs and allows for simple and rapid kinetics analysis (Ka, Kd, KD), protein detection and quantification, and assay development. 【Features】 ■ Measurement possible with just 4μL of a small sample ■ Ability to measure crude samples such as cell lysates in their unpurified state ■ Label-free assay that minimizes time and cost associated with labeling ■ No complicated setup, shutdown procedures, or maintenance required ■ Compact size that can be installed in a space smaller than A4 size ■ Kinetics analysis possible with reduced initial setup costs *For more details, please refer to the PDF document or feel free to contact us.

• Other physicochemical equipment

The "Mechanical Stitching Method" by Nichinichisui Road Machinery Co., Ltd. is a new technique that allows for the repair of metal cracks without the application of heat. By using special bolts and reinforcement plates, cracks are physically removed, and repairs are made without causing any thermal impact on the base material. Repairs can be carried out in environments where open flames cannot be used. Since no heat is applied, the disassembly of equipment is minimized. ◎ For more details, please contact us. ◎ If a detailed technical explanation is needed, please contact us.

The "Mechanical Stitching Method" by Nichinichisui Road Machinery Co., Ltd. is a new technique that allows for the repair of metal cracks without the application of heat. By using special bolts and reinforcement plates, cracks are physically removed, and repairs are made without causing any thermal impact to the base material. Repairs can be carried out in environments where open flames cannot be used. Since no heat is applied, the disassembly of equipment is minimized. ◎ For more details, please contact us. ◎ If a detailed technical explanation is needed, please contact us.

● The production time for casting prototypes can be shortened! Since model production is not required, the time needed to create prototypes, which previously took about a month, can be significantly reduced. ● Model costs can be reduced! By directly producing sand molds from 3D data, there is no need for model production costs. If changes to the model are necessary, they can be addressed by modifying the 3D data. ● Similar products with different shapes and dimensions can be prototyped simultaneously! With one molding process, different products with similar shapes or varying dimensions can be molded at the same time. This allows for the verification of multiple types in a short period.

Are you struggling to explain "safety" to the client using just drawings? - The risks in blind spots are difficult to convey to the client through drawings alone. - Safety measures often become a target for cost reduction, making it hard to communicate their necessity. - There is a concern that the client might say, "It's more dangerous than I thought," after completion. Risks that are visible to design professionals are not easily understood intuitively by clients who are outside the field. This document is not just a simple explanation of sensor functions; it is a guide to visually explain "why sensors are necessary in that location." It can be used directly as explanatory material for the client. Here are three key points for utilizing this document: 1. Visualization of Risks Blind spots during vehicle departure and contact risks within the site are illustrated clearly. 2. Clarification of Selection Criteria A comparison table outlines the differences between complex sensor types such as infrared, ultrasonic, and loop coils. 3. Diagram of System Configuration It illustrates not just the sensors alone, but how they combine with components like rotating lights and control panels, providing practical assistance for electrical equipment design. Please make use of this to prevent "rework after completion" and "accident risks."

In facilities operating nurse call systems, we have made the bed exit sensor wireless, allowing it to notify in conjunction with the nurse call system. By simply connecting the mat sensor "Foldable Thin Matt-kun," the body movement call "Ugo-kun," and the wheelchair body movement call "Ayumi-chan" to the transmitter HB-RS, you can make the bed exit sensor wireless. The infrared sensor "Just Place Pole-kun" has the transmitter HB-RS built-in. This helps prevent accidents caused by falls, slips, or wandering, contributing to the efficiency of medical operations. 【Features】 ○ Wireless conversion by simply connecting existing sensors to the transmitter HB-WSK. ○ The bed exit sensor notifies wirelessly in conjunction with the nurse call system. ○ Up to 5 transmitters can be registered with a single receiver. ○ The communication distance between the transmitter and receiver is approximately 10 meters. ◎ For more details, please contact us or download the catalog.