Integration of Hydrogen-Deuterium Exchange (HDX) Method with High-Resolution MS
Many harmful immune responses and diseases are believed to be caused by changes in protein conformation. Until now, X-ray crystallography and NMR-based analyses have primarily been used to measure protein conformation. While these analytical methods are useful, they are not applicable to all proteins and often require high-purity, large quantities of samples. Today, by effectively combining the ACQUITY M-Class HDX system with high-resolution mass spectrometry and rigorously controlling the temperature-sensitive aspects of the HDX sample preparation, we can reliably identify changes in protein conformation. This has made it possible to obtain detailed information about protein conformation. The ACQUITY M-Class HDX system adds a new dimension of separation capability, reproducibility, and durability to chromatography. 【Features】 - Binding of drugs to target molecules of proteins - Development of biopharmaceuticals - Protein-protein interactions - Research in structural biology For more details, please contact us or download the catalog.
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**Features** - Excellent chromatographic separation capability based on proven UPLC technology - Cutting-edge DynamX data analysis software in the industry → Reduces time from experiment to results with ProteinLynxGlobal Server (PLGS) 2.5 - Automation of system setup and operation is possible - Provides optimal separation capability with BEH Technology(TM) - Reduces solvent consumption through continuous direct nano-flow - Excellent reproducibility and reliability For more details, please contact us or download the catalog.
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Waters Corporation, headquartered in Milford, Massachusetts, USA, has played a pioneering role as a specialized manufacturer of liquid chromatography since its establishment in 1958. Actively engaged in the development of new products and technologies, it has grown into an international group company that supplies not only high-performance liquid chromatography but also mass spectrometers (MS) and thermal analysis instruments. Waters Japan started operations in 1973 (Showa 48) as the Japanese base of Waters Corporation. Inheriting the corporate ethos of the U.S. headquarters, we have made "Customer Success" our mission and continue to provide innovative technologies and lab solutions.