Automation of H3K27Me3 cell assays with Fluent.
Cisbio EPIgeneous cell-based assays allow for the direct measurement of methylation, demethylation, and total protein in both adherent and suspended cells. Tecan has achieved automation using the Fluent dispensing system, which is built based on the specific needs of lab applications. Fluent provides greater capacity and speed. This platform offers excellent throughput and walkaway time, enabling more reliable results and making it easier to perform many experimental processes. Tecan, in combination with Cisbio, known for its HTRF technology, has developed new protocols by combining expertise in automated liquid handling, detection, and cell-based assays. This enables the execution of fast, reliable, and fully automated assays.
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basic information
Epigenetics has played an important role in drug discovery for many years, but its significance has recently increased markedly in understanding the role of epigenetic modifications in cancer and stem cell differentiation. Methylation is a major epigenetic modification of DNA and histones that is involved in the regulation of gene expression. Epigenetic changes may persist throughout the lifespan of the cell itself due to cell division. They may also last across multiple generations, even in the absence of changes to the underlying DNA sequence of the organism. Therefore, epigenetic modifications can potentially be inherited. These modifications can be influenced by environmental factors and may trigger epigenetic effects that are involved in biological processes such as aging.
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Cell-based assay
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Company information
Tecan is a company that was established in Switzerland in 1980, specializing in the manufacturing and development of life science research support equipment. With the support of many customers, we were able to celebrate our 30th anniversary in Japan in 2022. Tecan Japan operates two businesses. One is the life sciences business, which delivers Tecan-branded products such as automated pipetting systems and microplate readers to end-users. The other is the partnering business, which provides components and equipment as OEM products for partner companies. Our customers span a wide range of fields, including disease research, drug discovery, biotechnology, clinical testing (such as cancer diagnosis, infectious disease diagnosis, and testing centers), scientific analysis, and robotic surgery. Our mission is to improve people's lives and health. Tecan Japan aims to contribute to global health care innovation from the life sciences industry to clinics by supporting our customers' daily activities.