High-density screening with the automated liquid handler Fluent.
Fluent achieves greater capacity and faster speeds. This platform offers excellent throughput and walkaway time, making it easier and more effective to conduct experiments. Tecan and Fraunhofer IME ScreeningPort have developed a protocol to demonstrate the capabilities of the Fluent laboratory automation solution for biochemical assays by combining their expertise in automated liquid handling. It has become possible to provide high-speed, reliable, and fully automated assays without the need for specialized automation personnel.
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The failure of preclinical pharmaceuticals is a significant issue for pharmaceutical companies, as it accounts for a considerable portion of valuable R&D budgets. As a result, there is a need to bring compound toxicity testing into high throughput, similar to primary efficacy screening. Drug metabolism is a crucial factor in compound toxicity, and cytochrome P450 (CYP), which is predominantly expressed in hepatocytes, plays a very important role in this metabolism. Currently, there are many screening assays designed to be automated in a microplate format for profiling compounds that may induce or inhibit CYP activity. This application note describes a lead generation method using three different CYP enzymes in a 384-well microplate format and presents typical assays performed in pharmacokinetics labs. IME's ScreeningPort division is engaged in the development of cell-based biochemical assay systems, high-throughput drug discovery, and biomarker identification. Tecan has implemented automation using its unique liquid handling device, Fluent, built around the application.
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Cell-based assay
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Company information
Tecan is a company that was established in Switzerland in 1980, specializing in the manufacturing and development of life science research support equipment. With the support of many customers, we were able to celebrate our 30th anniversary in Japan in 2022. Tecan Japan operates two businesses. One is the life sciences business, which delivers Tecan-branded products such as automated pipetting systems and microplate readers to end-users. The other is the partnering business, which provides components and equipment as OEM products for partner companies. Our customers span a wide range of fields, including disease research, drug discovery, biotechnology, clinical testing (such as cancer diagnosis, infectious disease diagnosis, and testing centers), scientific analysis, and robotic surgery. Our mission is to improve people's lives and health. Tecan Japan aims to contribute to global health care innovation from the life sciences industry to clinics by supporting our customers' daily activities.