Contributing to advancements in healthcare! Self-organizing peptide hydrogels with diverse applications.
"Self-Organizing Peptide Hydrogel" can acquire new properties by modifying peptide sequences or adding bioactive motifs, and its applications are diverse. Current application fields include chondrocytes, osteocytes, neurons, vascular endothelial cells, cardiomyocytes, stem cells, and maintenance of undifferentiated ES cells. 【Peptide Sequence Lineup and Features】 ○ RADA16 (PuraMatrix): Sequence Ac-(RADA)4-NH2 → Forms a fine structure (nanofibers) similar to natural ECM, allowing various cells to adhere. ○ KLD12: Sequence Ac-(KLDL)3-NH2 → A scaffold similar to RADA, forming a harder gel. ○ IEIK13: Sequence Ac-(EIKI)3-NH2 → Resistant to heat and enzymes, forming a harder gel at lower concentrations than RADA. For more details, please contact us or download the catalog.
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basic information
**Addition of Bioactive Motifs** ○ Peptide Name: PRG → Sequence: Ac-(RADA)4-GPRGDSGYRGDS-NH2 → Origin: Repeats of the RGD adhesion motif found in fibronectin → Features: Enhanced adhesion and proliferation for many types of cells → Current application fields: General adhesive cells, etc. ○ Peptide Name: SDP → Sequence: Ac-(RADA)4-GGSDPGYIGSR-NH2 → Origin: Cell adhesion sequence in laminin → Features: Improved adhesion and extensibility for vascular endothelial cells and nerve cells → Current application fields: Vascular endothelial cells, nerve cells, periodontal ligament cells, etc. ○ Peptide Name: PFS → Sequence: Ac-(RADA)4-GGPFSSTKT-NH2 → Origin: Bone marrow homing factor → Features: Differentiation and elongation from bone marrow and neural stem cells → Current application fields: Differentiation of bone marrow cells and neural stem cells, etc. ● For more details, please contact us or download the catalog.
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Applications/Examples of results
【Application Fields】 ○Regeneration of rabbit cartilage defects using KLD12 (without BMSCs and growth factors) ○Culture of MC3T3E1 cells using a mixed gel of RADA16 and PRG ●For more details, please contact us or download the catalog.
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Company information
3D Matrix Corporation is developing a global business based on various rights related to self-organizing peptide technology, focusing on research reagents, medical devices, and licensing. Centered around peptide technology licensed from MIT, the company is engaged in the development of technologies aimed at practical applications in the fields of regenerative medicine, surgical medicine, cell therapy, and drug discovery technology.