A device capable of simulating phenomena occurring in the subcutaneous environment of biopharmaceuticals.
The "Scissor N3" is a device that simulates phenomena occurring at the subcutaneous injection site of biopharmaceuticals. The physical behaviors that occur after various administration methods of conventional non-oral drugs are not well understood, but this product can simulate the chemical and various physical stresses that occur in the subcutaneous environment. Each experiment concludes within 24 hours and provides an in vitro model useful for studying bioavailability (BA) in subcutaneous administration. Additionally, it allows for offline analytical work (for example, concentration measurements using HPLC) to measure the concentration of excipients in samples. 【Features】 ■ High precision prediction of subcutaneous administration ■ Easy management of experiments ■ Connection to an auto-sampler (optional) ■ 4-channel exposure adjustment function ■ pH control through feedback loop *For more details, please refer to the catalog or feel free to contact us.
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basic information
【Research Subjects】 ■ Simulation of phenomena occurring at the subcutaneous injection site - Interaction between the sample and extracellular components - Transition process from the formulation's storage pH to physiological pH - Precipitation of the sample - Appropriateness of the selection of excipients and stabilizers ■ BA studies under simulation conditions - Subcutaneous administration - Intraocular administration ■ Comparative study of formulation methods for biological products - Formulations under development - Post-manufacturing formulations - Post-product formulations *For more details, please refer to the catalog or feel free to contact us.
Price range
P7
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For more details, please refer to the catalog or feel free to contact us.
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Company information
Physio-Machina Co., Ltd. is a company that primarily sells products such as formulation development equipment and dissolution testers, conducts validation and calibration of peripheral devices, and engages in the import and export of software and various equipment. Additionally, it actively provides translation and interpretation of technical documents and seminars, as well as support for the creation of SOPs and conducts training sessions.