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  6. Sievers TOC analyzer suitable for the pharmaceutical and semiconductor industries.

Sievers TOC analyzer suitable for the pharmaceutical and semiconductor industries.

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Sievers TOC Analyzer M9/M9e/M5310C

last updated:May 26, 2025

セントラル科学
セントラル科学
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Ultra-pure water for semiconductors, pharmaceutical water, tap water, wastewater and environmental water, and boiler water are all supported!

Organic matter contained in household and factory wastewater serves as food for aquatic organisms. While BOD and COD represent the amount of oxygen consumed for the decomposition of organic matter, TOC is a water pollution indicator that expresses the absolute amount of carbon contained in organic matter. TOC measurements are conducted across a wide range of industrial fields, from wastewater and environmental water to boiler water, ultra-pure water for semiconductors, and pharmaceutical manufacturing water. There are three series categorized by application fields, each offering three types: lab-type, portable-type, and online-type. ■ M9 Series ... For the pharmaceutical industry (compliant with 3 agencies), features Data Guard function compatible with 21 CFR part 11. ■ M9e Series ... For the semiconductor industry. ■ M5310C Series ... For the water supply sector, with a custom multi-point calibration protocol that complies with notification laws, and capable of meeting the requirements of the "Guidelines for the Validation of Water Quality Testing Methods." *For details, please request materials or view the PDF data available for download.

    Analytical Equipment and Devices
GEロゴなし_m9familycover-photo_小さめ2.jpg

Sievers TOC analyzer suitable for the pharmaceutical and semiconductor industries.

GEロゴなし_m9familycover-photo_小さめ2.jpg
GEロゴなし_m9familycover-photo_小さめ2.jpg
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basic information

Main equipment specifications of the TOC analyzer M9/M9e series (*Validation protocol built-in is only for the M9 series) Measurement method: Wet UV oxidation + gas permeable membrane conductivity measurement method Measurement range: (Normal) 0.03 ppb to 50 ppm, (Turbo mode) 0.2 to 10 ppm Measurement interval: (Normal) 2 minutes, (Turbo mode) 4 seconds Inorganic carbon removal device: Can be installed inside the main unit *For more details, please refer to the PDF or feel free to contact us.

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Applications/Examples of results

M9 Series... for the pharmaceutical industry, M9e Series... for the semiconductor industry M5310C Series... for the drinking water sector *For more details, please refer to the catalog or feel free to contact us.

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Model number overview
M9 Measurement range: 0.03ppb to 50ppm
M9e Measurement range: 0.03ppb to 50ppm
M5310C Measurement range: 4ppb to 50ppm

catalog(88)

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TOC Analyzer for Pharmaceuticals Sievers M9

TOC Analyzer for Pharmaceuticals Sievers M9

PRODUCT
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TOC meter for cleaning validation

TOC meter for cleaning validation

PRODUCT
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Pharmaceutical Water/Cleaning Validation Sievers M9 Laboratory Type

Pharmaceutical Water/Cleaning Validation Sievers M9 Laboratory Type

PRODUCT
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Purified Water/Injection Water Management Sievers TOC Meter Online/Portable Type

Purified Water/Injection Water Management Sievers TOC Meter Online/Portable Type

PRODUCT
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Performance comparison of TOC analyzers Sievers 900 and M9 models.

Performance comparison of TOC analyzers Sievers 900 and M9 models.

TECHNICAL
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Water quality monitoring of ultrapure water production systems for semiconductors (TOC & boron)

Water quality monitoring of ultrapure water production systems for semiconductors (TOC & boron)

TECHNICAL
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Evaluation of manufacturing equipment cleaning by TOC

Evaluation of manufacturing equipment cleaning by TOC

TECHNICAL
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Utilization of TOC monitoring for food/beverage manufacturers

Utilization of TOC monitoring for food/beverage manufacturers

TECHNICAL
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Water quality management and leak detection for boiler water and cooling water using TOC.

Water quality management and leak detection for boiler water and cooling water using TOC.

TECHNICAL
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Optimization Tool for Water Treatment Processes for Water Utilities

Optimization Tool for Water Treatment Processes for Water Utilities

TECHNICAL
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Purity management of chemical substances by TOC

Purity management of chemical substances by TOC

TECHNICAL
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Swab TOC recovery rate of the compound in the worst-case scenario (feasibility test)

Swab TOC recovery rate of the compound in the worst-case scenario (feasibility test)

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Differences in TOC measurement values due to sampling methods

Differences in TOC measurement values due to sampling methods

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Reduction of boiler operating costs through TOC calculation

Reduction of boiler operating costs through TOC calculation

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TOC helps to protect the product quality of spice manufacturers.

TOC helps to protect the product quality of spice manufacturers.

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Sievers M Series Turbo Mode for Rapid Liquid Leak Detection

Sievers M Series Turbo Mode for Rapid Liquid Leak Detection

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TOC recovery rate of gluten using Sievers M9

TOC recovery rate of gluten using Sievers M9

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Food and beverage manufacturers improve production efficiency and quality control through TOC analysis of cleaning cycles.

Food and beverage manufacturers improve production efficiency and quality control through TOC analysis of cleaning cycles.

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Solving water treatment challenges in power generation facilities through TOC monitoring.

Solving water treatment challenges in power generation facilities through TOC monitoring.

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Early detection of ethylene glycol leaks in steam condensate at power plants.

Early detection of ethylene glycol leaks in steam condensate at power plants.

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Monitoring of cooling wastewater using TOC measurement.

Monitoring of cooling wastewater using TOC measurement.

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Online monitoring of TOC and boron for the generation of high-purity steam and efficient power generation.

Online monitoring of TOC and boron for the generation of high-purity steam and efficient power generation.

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Protection of RO membranes using an online TOC meter by Tampa Electronic Pork Power Plant.

Protection of RO membranes using an online TOC meter by Tampa Electronic Pork Power Plant.

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Recovery rate of volatile compounds by TOC measurement

Recovery rate of volatile compounds by TOC measurement

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Monitoring of organic matter in the condensate of boiler equipment using TOC in a European animal feed factory.

Monitoring of organic matter in the condensate of boiler equipment using TOC in a European animal feed factory.

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Water Quality Monitoring at Oil Refineries: The Impact of Real-Time Data on Compliance with Quality Regulations and Reuse

Water Quality Monitoring at Oil Refineries: The Impact of Real-Time Data on Compliance with Quality Regulations and Reuse

TECHNICAL
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Condensate monitoring for leak detection and equipment protection using Sievers TOC measurement.

Condensate monitoring for leak detection and equipment protection using Sievers TOC measurement.

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Sievers Brown TOC Vial

Sievers Brown TOC Vial

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Sievers TOC Vial Style_Infographic

Sievers TOC Vial Style_Infographic

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Monitoring of organic substances in industrial water using the Sievers TOC analyzer.

Monitoring of organic substances in industrial water using the Sievers TOC analyzer.

TECHNICAL
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Paradigm shift in the monitoring methods of organic matter in drainage.

Paradigm shift in the monitoring methods of organic matter in drainage.

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Real-time release through online cleaning validation using total organic carbon, inorganic carbon, and conductivity data.

Real-time release through online cleaning validation using total organic carbon, inorganic carbon, and conductivity data.

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TOC recovery rate of complex compounds: cleaning agents

TOC recovery rate of complex compounds: cleaning agents

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Comparison of TOC Cleaning Validation Swab Kits.

Comparison of TOC Cleaning Validation Swab Kits.

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TOC measurement of 0.2M sodium hydroxide using the Sievers M9 type.

TOC measurement of 0.2M sodium hydroxide using the Sievers M9 type.

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TOC measurement of 0.2M potassium hydroxide using the Sievers M9 type.

TOC measurement of 0.2M potassium hydroxide using the Sievers M9 type.

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Simultaneous measurement of TOC and conductivity to analyze non-conductive organic substances in cleaning agents.

Simultaneous measurement of TOC and conductivity to analyze non-conductive organic substances in cleaning agents.

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TOC recovery rate using STERIS Life Sciences' cleaning agent_Sievers M9 type

TOC recovery rate using STERIS Life Sciences' cleaning agent_Sievers M9 type

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Validation of TOC Method for Cleaning Validation in the Pharmaceutical Industry

Validation of TOC Method for Cleaning Validation in the Pharmaceutical Industry

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Calculation of Maximum Allowable Carryover (MAC) in Cleaning Validation

Calculation of Maximum Allowable Carryover (MAC) in Cleaning Validation

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Sievers Validation Support Package for Cleaning Validation

Sievers Validation Support Package for Cleaning Validation

TECHNICAL
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PAT Application: At-line TOC measurement for cleaning validation and product changeover.

PAT Application: At-line TOC measurement for cleaning validation and product changeover.

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Reduction of cleaning validation and product changeover costs by 92% through in-line TOC measurement.

Reduction of cleaning validation and product changeover costs by 92% through in-line TOC measurement.

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Cleaning validation: Verifying the performance of the cleaning process.

Cleaning validation: Verifying the performance of the cleaning process.

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Evaluation of the validity of cleaning standards based on engineering capability index

Evaluation of the validity of cleaning standards based on engineering capability index

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Analysis method for cleaning validation

Analysis method for cleaning validation

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Detection of TOC and conductivity of CIP-100 using the Sievers M series.

Detection of TOC and conductivity of CIP-100 using the Sievers M series.

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TOC recovery rate of insoluble and difficult-to-decompose compounds

TOC recovery rate of insoluble and difficult-to-decompose compounds

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Cost comparison of TOC and HPLC (using TOC analyzers for cleaning validation)

Cost comparison of TOC and HPLC (using TOC analyzers for cleaning validation)

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Sievers M9 type used for lab_atline_online_cleaning_validation

Sievers M9 type used for lab_atline_online_cleaning_validation

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Real-time low-flow cleaning efficacy evaluation of pharmaceuticals using TOC and conductivity.

Real-time low-flow cleaning efficacy evaluation of pharmaceuticals using TOC and conductivity.

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Cleaning evaluation: Microbial TOC recovery rate and linearity

Cleaning evaluation: Microbial TOC recovery rate and linearity

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Best Practices for Measuring Conductivity of Sievers M9 Type in Pharmaceutical Water

Best Practices for Measuring Conductivity of Sievers M9 Type in Pharmaceutical Water

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Measurement of conductivity and TOC using Sievers M9.

Measurement of conductivity and TOC using Sievers M9.

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Sievers M9 Conductivity Measurement USP 645 Improvement of Stage 1 Robustness and Best Practices

Sievers M9 Conductivity Measurement USP 645 Improvement of Stage 1 Robustness and Best Practices

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Conductivity & TOC dual-use (DUCT) vial

Conductivity & TOC dual-use (DUCT) vial

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Performance and Stability of DUCT Vials

Performance and Stability of DUCT Vials

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TOC & Conductivity Sample Storage Container

TOC & Conductivity Sample Storage Container

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Conductivity & TOC Sampling Standard Operating Procedure

Conductivity & TOC Sampling Standard Operating Procedure

MANUAL
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Simultaneous measurement of TOC and conductivity for efficiency improvement and cost reduction.

Simultaneous measurement of TOC and conductivity for efficiency improvement and cost reduction.

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Linearity of conductivity in low concentration range - TOC measurement Sievers M9 sample conductivity measurement function

Linearity of conductivity in low concentration range - TOC measurement Sievers M9 sample conductivity measurement function

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Suitability of Conductivity Measurement for M9_EP Monograph_EP2.2.38_USP645

Suitability of Conductivity Measurement for M9_EP Monograph_EP2.2.38_USP645

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Simultaneous measurement of conductivity USP Stage 1 and TOC of pharmaceutical water in the lab.

Simultaneous measurement of conductivity USP Stage 1 and TOC of pharmaceutical water in the lab.

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Screening of USP 661.1 plastic packaging materials using the TOC meter Sievers M9 type.

Screening of USP 661.1 plastic packaging materials using the TOC meter Sievers M9 type.

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TOC analysis of leachables in USP661 (Plastic Packaging Systems and Materials).

TOC analysis of leachables in USP661 (Plastic Packaging Systems and Materials).

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Management and Maintenance of Pharmaceutical Water Systems Using the TOC Meter Sievers M9 Portable Type

Management and Maintenance of Pharmaceutical Water Systems Using the TOC Meter Sievers M9 Portable Type

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Cost Savings in Water Treatment through Raw Water Variation Monitoring: Process Management Using TOC at Water Treatment Plants

Cost Savings in Water Treatment through Raw Water Variation Monitoring: Process Management Using TOC at Water Treatment Plants

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Improvement of water treatment reliability through control of coagulant dosage using TOC.

Improvement of water treatment reliability through control of coagulant dosage using TOC.

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Comparison of TOC and UV Absorbance in Water Treatment

Comparison of TOC and UV Absorbance in Water Treatment

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TOC analysis as an optimization tool for water treatment processes at water purification plants.

TOC analysis as an optimization tool for water treatment processes at water purification plants.

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Optimization of the MIEX system using TOC.

Optimization of the MIEX system using TOC.

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Enhancement of process control for ion exchange systems for NOM and DBP management.

Enhancement of process control for ion exchange systems for NOM and DBP management.

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Optimization of Eutrophication Prevention through TOC Analysis

Optimization of Eutrophication Prevention through TOC Analysis

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Optimization of Eutrophication Prevention through TOC Analysis

Optimization of Eutrophication Prevention through TOC Analysis

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Process optimization and regulatory compliance using TOC at a water treatment plant: Helena, Montana, USA.

Process optimization and regulatory compliance using TOC at a water treatment plant: Helena, Montana, USA.

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Utilization of Organic Matter Monitoring in Direct Drinking Water Reuse Plants: A Solution to Water Shortages Due to Droughts.

Utilization of Organic Matter Monitoring in Direct Drinking Water Reuse Plants: A Solution to Water Shortages Due to Droughts.

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Plans for the Future: Water Quality Protection Using Granular Activated Carbon Treatment and TOC Analysis

Plans for the Future: Water Quality Protection Using Granular Activated Carbon Treatment and TOC Analysis

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Reliable organic monitoring for water reuse.

Reliable organic monitoring for water reuse.

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Quality assurance of cooling water using M5310C.

Quality assurance of cooling water using M5310C.

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TOC Measurement Support Tool

TOC Measurement Support Tool

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Sievers Products Standard Solutions & Consumables Catalog

Sievers Products Standard Solutions & Consumables Catalog

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【Water/Environmental Water】TOC Analyzer Sievers M5310C

【Water/Environmental Water】TOC Analyzer Sievers M5310C

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TOC standard solution

TOC standard solution

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Sievers TOC Sensor CheckPoint Pharma

Sievers TOC Sensor CheckPoint Pharma

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Comparison of TOC measurements in the cleaning validation of protein samples.

Comparison of TOC measurements in the cleaning validation of protein samples.

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TOC Analyzer Sievers M9e for the Semiconductor/Electronics Industry

TOC Analyzer Sievers M9e for the Semiconductor/Electronics Industry

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Sievers TOC Sensor CheckPoint e

Sievers TOC Sensor CheckPoint e

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Conductivity Bridging Study: From Laboratory Conductivity Meter to Sievers M9 Type

Conductivity Bridging Study: From Laboratory Conductivity Meter to Sievers M9 Type

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セントラル科学

セントラル科学

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Since our establishment in 1967, we have been dedicated to the development and dissemination of water quality measurement devices that anyone can use quickly, easily, and with high precision. In today's world, where the effective use of water, a limited resource, is required alongside environmental conservation, we aim to be a total solution provider that responds to all water environments by utilizing our water quality measurement devices, technology, and services. Furthermore, leveraging the latest technology and years of know-how, we are committed to delivering user-friendly and reliable water quality measurement devices more affordably, quickly, and widely.

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