Contract development of fermentation processes *Support from small-scale culture trials to commercial GMP production.
Partner companies have extensive experience and achievements in the improvement of production strains for useful substances and recombinant technology, and they undertake research and development to meet a wide range of needs.
We provide customized services for the production of metabolites by microorganisms. We offer options for optimizing production and purification processes, as well as improving cost-effectiveness. Additionally, we can accommodate everything from small-scale culture trials to commercial-scale GMP production. *For more details, please download our catalog or feel free to contact us.*
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basic information
1. Improvement of metabolite yield and suppression of impurities/by-products through strain modification. 2. Microbial screening: Screening a microbial library using specially designed media and fermentation conditions to find strains capable of the desired bioconversion/biotransformation. 3. Improvement of fermentation processes. 4. Consideration of scale-up from shake flasks to fermentation tanks (5, 10, 30, 125L). 5. Experience in handling a wide range of strains including bacteria, actinomycetes, fungi, yeast, and anaerobic microorganisms. 6. Provision of the microbial library itself. *For more details, please download the catalog or feel free to contact us.*
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Applications/Examples of results
Upstream Process Development (UDP) ・Strain Improvement ・Microbial Culture using High-Density Feeding Systems Downstream Process Development (DSP) ・Refolding Process for E. coli Expression Systems ・Purification Process using Centrifugation and Fine Filtration *For more details, please download the catalog or feel free to contact us.
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Company information
Libra Medicina Co., Ltd. aims to contribute to the improvement of health and quality of life for people around the world by being involved in the creation of innovative pharmaceuticals and medical devices through development support services and licensing activities, delivering hope to patients suffering from serious diseases.