Reduce the amount of test substances and costs! It is possible to link toxicity evaluation with blood drug concentration!
Inari Research utilizes the method of "Microsampling," which involves blood collection of 50μL or less, in small animal safety testing. This consideration aligns with the 3Rs (Reduction, Replacement, Refinement). We obtain TK Profiles using toxicology test animals (rats and marmosets). Additionally, we can link toxicity evaluations to blood drug concentrations, reduce the amount of test substances, and lower costs. 【Features】 ■ Consideration for the 3Rs (Reduction, Replacement, Refinement) ■ Obtaining TK Profiles using toxicology test animals (rats and marmosets) ■ Conducting TK on the same satellite animals (mice) ■ Ability to link toxicity evaluations to blood drug concentrations ■ Reduction of test substance amounts and cost savings In Plasma Micro-Sampling (PMS): ■ Blood collection volume reduced to 1/15 to 1/10 ■ Measurement sensitivity increased by 20 times *Please feel free to contact us regarding toxicology test design and the development of high-sensitivity measurement methods.
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【Method】 ■Reduced blood sampling volume to 1/15 to 1/10 using Plasma Micro-Sampling (PMS) ■Increased measurement sensitivity by 20 times through miniaturization of high-sensitivity MS and inlet LC 【Impact of Microsampling】 ■Evaluation Items - General condition: body weight, food intake, hematological tests, blood biochemical tests, necropsy pathological histological examination (mice, rats, and marmosets) - Water intake, ophthalmological examination, urinalysis, FOB, blood pressure, blood gases (marmosets only) ■Rats: No impact ■Mice: Transient decrease in body weight and food intake, anemia ■Marmosets: No impact *For more details, please refer to the PDF document or feel free to contact us.
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For more details, please refer to the PDF document or feel free to contact us.
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Our company is located in the nature-rich city of Ina, Nagano Prefecture, surrounded by two Alps, and has been serving our customers as a non-clinical trial contract research organization (CRO) for 50 years. Since 2022, we have become a member of the Shin Nippon Science Group, expanding and enhancing our contract testing items and analyses, and we can quickly respond to the procurement of various testing materials (such as animals). Non-Clinical Trial Business We accept safety and efficacy testing for pharmaceuticals, chemicals, pesticides, food, medical devices, and more. We conduct in vivo tests using small animals, rabbits, dogs, and monkeys, as well as in vitro tests using bacteria and cells, and various alternative method tests. Additionally, we specialize in the creation of SEND data required for FDA applications for new drugs, and we also undertake work related to SEND conversion and QC for data creation and conversion only. Our facility was the first in Japan to obtain full accreditation from AAALAC International (the Association for Assessment and Accreditation of Laboratory Animal Care International), and we are committed to international standards of animal welfare. We also propose tests necessary for various applications and registrations in compliance with regulations in different countries and regions.