"Safety Testing of Pharmaceuticals Using Marmosets" *Presentation materials for the conference are provided.
Detection of human-like responses with a small amount of test substance. Successful development of a new CPP test.
Our company conducts "safety testing of pharmaceuticals using marmosets," which allows for the efficient acquisition of non-clinical data. Marmosets are small primates weighing between 250 to 500 grams, providing the following advantages for conducting tests, such as requiring smaller amounts of test substances. 【Features】 ◎ Compared to cynomolgus monkeys, valuable test substances are needed in smaller quantities (about 1/10) ◎ Compared to rats and dogs, human-like pharmacological reactivity can be expected ★ Currently, we are compiling and presenting "conference presentation materials" summarizing test data and more. You can view them immediately via the "Download" link.
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basic information
Inari Research is developing the following safety evaluation systems necessary for IND applications in collaboration with the Public Interest Incorporated Foundation Central Institute for Experimental Animals (CIEA). - Repeated dose toxicity testing - Safety pharmacology testing (FOB testing, telemetry testing, etc.) - A composite repeated dose test incorporating safety pharmacology testing (central nervous system, cardiovascular system, respiratory system) and TK measurement Furthermore, we have successfully developed a test for psychological dependence using marmosets (CPP test: conditioned place preference test). Compared to the general rat CPP test, this method is expected to detect psychological dependence on central nervous system depressants with high accuracy. All of our development tests have been validated as effective through verification tests with known drugs. *For more details, please refer to the materials. Feel free to contact us with any inquiries.
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Company information
Our company is located in the nature-rich city of Ina, Nagano Prefecture, surrounded by two Alps, and has been serving our customers as a non-clinical trial contract research organization (CRO) for 50 years. Since 2022, we have become a member of the Shin Nippon Science Group, expanding and enhancing our contract testing items and analyses, and we can quickly respond to the procurement of various testing materials (such as animals). Non-Clinical Trial Business We accept safety and efficacy testing for pharmaceuticals, chemicals, pesticides, food, medical devices, and more. We conduct in vivo tests using small animals, rabbits, dogs, and monkeys, as well as in vitro tests using bacteria and cells, and various alternative method tests. Additionally, we specialize in the creation of SEND data required for FDA applications for new drugs, and we also undertake work related to SEND conversion and QC for data creation and conversion only. Our facility was the first in Japan to obtain full accreditation from AAALAC International (the Association for Assessment and Accreditation of Laboratory Animal Care International), and we are committed to international standards of animal welfare. We also propose tests necessary for various applications and registrations in compliance with regulations in different countries and regions.