High-sensitivity and high-precision measurement of metabolic fluctuations in central metabolism that can only be detected with CE-QqQMS!
"Sea Scope" is a metabolome analysis service that measures metabolic fluctuations in central metabolism (energy, amino acids, nucleic acid metabolism) with high sensitivity and precision, detectable only by CE-QqQMS. Since absolute concentrations of metabolites can be obtained, it is possible to compare the pool sizes of different metabolites and calculate metabolic parameters such as the energy charge of nucleic acids and the pool size of function-specific amino acids. The metabolic parameters reported can only be calculated when the absolute amounts (concentrations) of metabolites are obtained. Knowing the concentrations allows for comparisons between different substances, adjustments between different substances, and comparisons of test data analyzed across different batches. 【Features】 ■ Understanding primary metabolism leads to a better understanding of life ■ Achieves excellent detection sensitivity and quantification range ■ Derives more rational interpretations from metabolic parameters ■ Enables immediate publication of research results *For more details, please refer to the PDF document or feel free to contact us.
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【Overview】 ■Analysis Target ・116 substances included in central energy metabolism ・Glycolysis/gluconeogenesis, TCA cycle, pentose phosphate pathway, lipid metabolism, amino acid metabolism, nucleic acid metabolism, etc. ■Number of Detected Substances ・Blood, culture medium: 50 to 80 ・Animal and plant tissues: 90 or more ・Cultured cells: 90 or more ■Sample Types: Animal tissues (liver, muscle, brain), cultured cells, animal blood, culture medium, cultured microbial cells (yeast, E. coli) ■Report Values ・Concentration in samples ・30 metabolic parameters ■Report ・Concentration in samples for 116 targeted metabolites, 30 metabolic parameters, statistical analysis (PCA, heat map) results, and pathway mapping ■Statistical Analysis and Pathway Analysis: Free of charge ■Estimated Delivery Time: 20 to 60 days *For more details, please refer to the PDF document or feel free to contact us.
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【Main Uses】 ■ Mechanism analysis focusing on energy metabolism ■ Research requiring stable analysis over a long period *For more details, please refer to the PDF document or feel free to contact us.
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Substances such as amino acids, fatty acids, and organic acids play a significant role in maintaining biological functions in all living organisms, including animals and plants. These substances are referred to as metabolites (metabolome). In everyday life, metabolites (metabolome) are also related to the nutrients and flavors of food. Glutamic acid, known for its umami component, as well as GABA, DHA, and EPA, which are often mentioned in functional food labeling, are also considered "metabolites." Human Metabolome Technologies, Inc. (HMT) is a research and development venture that focuses on innovative analytical technologies that enable the analysis of metabolites contained in various samples, offering contract analysis services. HMT's metabolome contract analysis supports research and development across various fields, including drug discovery, healthcare, food, and chemistry. In recent years, we have been utilized for a wide range of applications, including biomarker discovery, development of functional foods, exploration and evaluation of new active ingredients, and enhancing the branding value of in-house products. <Our Features> - A unique product lineup centered on the innovative analytical technology of CE-MS - Over 5,000 analysis achievements - Pre-examination consultations and post-examination follow-ups by experts
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