Analyze metabolites labeled with 13C! Present changes in activity and reaction direction for each metabolic pathway.
"F-Scope" is a new contract analysis service that allows for stable isotope labeling analysis. By analyzing metabolites labeled with 13C, it definitively presents the increase or decrease in activity for each metabolic pathway and the direction of those reactions. 【What is isotope labeling analysis?】 ■ Isotopes are atoms that have a different mass than those commonly found in nature. Since the isotopes remain unchanged even when the substrate containing them is metabolized and converted into another substance, they can be treated as "labels." ■ Mass spectrometers can distinguish between isotopes, allowing for the analysis of which metabolic pathway the substrate has gone through and what it has been converted into. *For more details, please refer to the PDF document or feel free to contact us.
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【Overview】 ■Analysis Target - 30 metabolites including glycolysis/gluconeogenesis, TCA cycle, pentose phosphate pathway, etc. - Or 54 metabolites including those plus 24 metabolites such as amino acids. ■Sample Types: Animal cultured cells, microbial cultured cells, culture media, animal tissues, etc. ■Report Values - Relative area values of all peaks and the sum of each substance. - Concentration of the sum of each substance in the sample (1 point measurement). ■Report - Report on detected peaks and relative area values of the sum of each metabolite, concentration of the sum of each substance in the sample, and pathway mapping. ■Statistical Analysis/Pathway Analysis: Free (displays total amount of each substance and relative area values of mono-isotopic ions in pathways). ■Label: 13C ■Estimated Delivery Time: 20 to 60 days *For more details, please refer to the PDF document or feel free to contact us.
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【Main Uses】 ■ Label analysis in energy metabolism *For more details, please refer to the PDF document or feel free to contact us.
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Substances such as amino acids, fatty acids, and organic acids play a significant role in maintaining biological functions in all living organisms, including animals and plants. These substances are referred to as metabolites (metabolome). In everyday life, metabolites (metabolome) are also related to the nutrients and flavors of food. Glutamic acid, known for its umami component, as well as GABA, DHA, and EPA, which are often mentioned in functional food labeling, are also considered "metabolites." Human Metabolome Technologies, Inc. (HMT) is a research and development venture that focuses on innovative analytical technologies that enable the analysis of metabolites contained in various samples, offering contract analysis services. HMT's metabolome contract analysis supports research and development across various fields, including drug discovery, healthcare, food, and chemistry. In recent years, we have been utilized for a wide range of applications, including biomarker discovery, development of functional foods, exploration and evaluation of new active ingredients, and enhancing the branding value of in-house products. <Our Features> - A unique product lineup centered on the innovative analytical technology of CE-MS - Over 5,000 analysis achievements - Pre-examination consultations and post-examination follow-ups by experts
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