Agilent fiber optic for dissolution testing UV-Vis spectrophotometer
Agilent Technologies Cary60 Fiber Optic UV-Vis Spectrophotometer
Real-time sample analysis and observation of supersaturation maintenance in elution tests using fiber optic.
Solid dispersions are used to improve the solubility of poorly soluble drugs. Although solid dispersions are in a supersaturated state, it is important to maintain this state. Using Fiber Optic for real-time monitoring allows for more detailed data acquisition and is more effective. By changing the chip (optical path length), it can accommodate a wide range of drug concentrations. 【Features】 - Data acquisition at intervals as short as 45 seconds - Direct absorbance measurement within the vessel - Reduced risk of contamination and carryover - Correction function for excipient interference and background - No need for flow path cleaning - Reduced maintenance costs as it does not use pumps (moving parts) or filters - 21 CFR Part 11 compliant UV dissolution software
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basic information
The Fiber Optic Online UV Leaching Test System is ideal for automating tests and ensuring data integrity. The multiplexer allows for quick position switching, minimizing time lag during sample analysis. The interchangeable chips accommodate various sample concentrations by selecting the optical path length. 【Specifications】 - Wavelength range: 190–1100nm - Resolution: 1.5nm - Wavelength accuracy: ±0.5nm - Wavelength reproducibility: ±0.1nm - Light source: Xenon flash - Chip (optical path length): 1–20mm Includes 6 fiber cables; chips (optical path length) can be selected from the sizes above.
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Applications/Examples of results
- Online dissolution testing - Measurement of intrinsic solubility - Drug evaluation tests for solid dispersions - Maintenance of supersaturation in dissolution testing (crystallization suppression) - Dissolution testing of poorly soluble drugs
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Starting as an import trading company in 1927, we have been developing our business with many overseas suppliers and domestic customers over the years. Through our services of connecting the two together, Higuchi has become the well trusted "Japan distribution channel" for suppliers, and the "dependable vendor" who provides a stable supply of the latest high-valued overseas products to customers. Today, we conduct not only importing but also exporting businesses, trilateral trades, and overseas business investments as well. We have also expanded to local subsidiaries in the United States and China, to which we are able to effectively network overseas. Higuchi believes in the criticalness of providing a stable supply to customers, and we also place the highest priority on the coexistence with suppliers, to whom we can mutually develop together in a long-term perspective. Your support and consideration to our corporate philosophy would be much appreciated.