For the evaluation of the dissolution properties of active pharmaceutical ingredients! Intrinsic solubility measurement.
Agilent Intrinsic Dissolution
USP<1087> Measurement of Intrinsic Solubility by the Intrinsic Dissolution Method
The intrinsic method for dissolution testing provides important information about the active pharmaceutical ingredient by determining the dissolution rate from a test solution with a constant pH, temperature, and surface area. The Biopharmaceutics Classification System (BCS) classifies the characteristics of a drug's solubility and membrane permeability, while the intrinsic method can characterize solubility.
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basic information
The dissolution rate is expressed as the mass of the sample that dissolves per unit time in the elution test solution. The sample concentration is plotted against time and surface area as mg/min/cm², and the slope of the line becomes the intrinsic solubility constant. The intrinsic solubility constant also provides information about physical properties, crystallinity, polymorphism, solvation, and more.
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P3
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Applications/Examples of results
Determination of intrinsic solubility
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Starting as an import trading company in 1927, we have been developing our business with many overseas suppliers and domestic customers over the years. Through our services of connecting the two together, Higuchi has become the well trusted "Japan distribution channel" for suppliers, and the "dependable vendor" who provides a stable supply of the latest high-valued overseas products to customers. Today, we conduct not only importing but also exporting businesses, trilateral trades, and overseas business investments as well. We have also expanded to local subsidiaries in the United States and China, to which we are able to effectively network overseas. Higuchi believes in the criticalness of providing a stable supply to customers, and we also place the highest priority on the coexistence with suppliers, to whom we can mutually develop together in a long-term perspective. Your support and consideration to our corporate philosophy would be much appreciated.