Aiming to shorten the development period and reduce the development costs of new drugs through the creation of a device that replicates the human intestinal environment!
In 2018, the Sakai-Nishikawa Laboratory of the Department of Chemical System Engineering at the University of Tokyo was developing a device called "Intestinal MPS (Microphysiological System)" to replicate the human intestinal environment as part of a human mimicry project promoted by AMED. To recreate blood flow and peristaltic movement in the intestinal tract within plates used for culturing iPS cells for drug discovery experiments, the laboratory initially handmade prototypes or requested trials from pharmaceutical manufacturers. However, they could not find a company capable of producing complex prototypes that required intricate control and had no plans for mass production. They then consulted Takasago Electric Industry, which specializes in microfluidic control and small-batch, customized production. For the reproduction of blood flow, they utilized a perfusion device (a culture apparatus that continuously flows culture medium) that had already been developed in-house. However, there were no valves that could operate at the required speed for simulating peristaltic movement, so they came up with the idea of using a valve to send air into the plate and move the culture membrane using air pressure, leading to trial and error. Finally, in January 2019, they successfully combined a micro needle valve capable of flow adjustment with a quantitative pump, enabling them to move the culture membrane at the requested speed.
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For more details, please visit our website. 【3D Perfusion Culture System】 - Achieves an in vivo-like culture environment within the well! - Optimal as a three-dimensional tissue culture system for liver, nerve cells, myocardium, etc. - Easily try perfusion culture with your own incubator. - Control the strength of shear stress. - Compatible with standard 6-well plates. 【Microneedle Valve MNV Series】 - Manual adjustment of micro flow rates below 1 μl/min! - Reduces pump pulsation by constricting the flow rate. - Uses corrosion-resistant materials for the wetted parts. 【6-Channel Pump】 - Compact yet capable of delivering 1 to 6 types of liquids simultaneously. - Easy tube replacement. - There is a stepping motor type that allows control of a minimum flow rate of 0.23 μl/min. - If using tubes from the same lot, the delivery variation between the 6 tubes is within ±10%. 【Quantitative Discharge Pump PKP Series】 - A quantitative discharge pump with a maximum discharge volume of 500 μl. - The discharge volume adjustment range per shot is 50 to 500 μl, with manual adjustment available.
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As part of the Human Body Imitation Project, the Sakai-Nishikawa Laboratory of the Department of Chemical System Engineering at the University of Tokyo is contributing to the development of a device called "Intestinal MPS (Microphysiological System)" that replicates the human intestinal environment.
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Our company has been a specialized manufacturer of over 10,000 types of solenoid valves, small pumps, and other fluid control devices for more than 60 years, providing technology related to automatic and precise control of liquids and gases. We excel in custom design tailored to the individual needs of our customers and are expanding globally. 【Customization】 As a specialist in fluid control, we flexibly respond to all product design requirements from our customers. Based on our extensive experience and fresh ideas, we actively propose various product customizations according to individual requests. We also accommodate small-scale prototypes, so please feel free to reach out. 【Miniaturization】 We are developing small and micro fluid control products, including the world's smallest class of small valves, the FV and FLV series. 【Integration】 If you provide us with your desired specifications and an overall flow diagram, we will consider the optimal selection and arrangement of components and propose integration products. <<Others>> - Established a seismic isolation factory compliant with BCP - Opened a branch in the United States in October 2012 as part of our global expansion.