Compact design, easy operation, fully automatic TFF system providing flexibility in the manufacturing process.
Single-use technology brings many benefits to biopharmaceutical manufacturing, enabling simpler operations. Single-use TFF systems simplify the process of ultrafiltration/diafiltration by fully controlling key parameters. ▪ Excellent engineering design that provides reliability, control performance, and ease of use ▪ Fully automated control and monitoring of process parameters ▪ Equipped with calibrated sensors, gamma-sterilized manifolds can be installed quickly and easily
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basic information
Single-use technology is widely accepted in the biopharmaceutical manufacturing process, offering a flexible system with advantages such as reduced risk of cross-contamination and the elimination of the need for cleaning processes. The Allegro single-use TFF system's single-use manifold consists of supply lines, return lines, permeate lines, lines connecting to biocontainers, and recovery lines, all of which are gamma-sterilized and can be connected to the system immediately. ▪ A volumetric diaphragm pump is adopted to ensure that important parameters do not change even during concentration operations, preventing flow reduction due to pressure increases and achieving circulation at a constant flow rate. ▪ Time-based management of process parameters is possible. ▪ Fully automated control of TMP and circulation flow rate. ▪ Analytical tools for trend analysis and calculations. ▪ Data logging and batch reporting.
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Applications/Examples of results
The single-use TFF system is designed for the processes of ultrafiltration and diafiltration. Its typical applications include the concentration and diafiltration of proteins, recombinant molecules, highly active biopharmaceuticals, cytotoxic drugs, and vaccines.
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Company information
Sartorius Stedim, established in 2007 through the merger of the German company Sartorius, founded in 1870, and the French company Stedim, is a pioneer in "Single-Use Technology (SUT)." As a company capable of providing comprehensive technical support to the pharmaceutical and biotechnology industries, its cutting-edge technology is highly regarded worldwide in the fields of scientific instruments and biotechnology.