Fully automatic single-use TFF system

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basic information

Single-use technology is widely accepted in the biopharmaceutical manufacturing process, offering a flexible system with advantages such as reduced risk of cross-contamination and the elimination of the need for cleaning processes. The Allegro single-use TFF system's single-use manifold consists of supply lines, return lines, permeate lines, lines connecting to biocontainers, and recovery lines, all of which are gamma-sterilized and can be connected to the system immediately. ▪ A volumetric diaphragm pump is adopted to ensure that important parameters do not change even during concentration operations, preventing flow reduction due to pressure increases and achieving circulation at a constant flow rate. ▪ Time-based management of process parameters is possible. ▪ Fully automated control of TMP and circulation flow rate. ▪ Analytical tools for trend analysis and calculations. ▪ Data logging and batch reporting.

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Applications/Examples of results

The single-use TFF system is designed for the processes of ultrafiltration and diafiltration. Its typical applications include the concentration and diafiltration of proteins, recombinant molecules, highly active biopharmaceuticals, cytotoxic drugs, and vaccines.