Barrier function has increased by 25% compared to conventional methods! Successfully built an in vitro BNB model with a two-layer structure.
Many peripheral nerve diseases are associated with the disruption of the blood-nerve barrier (BNB), and it is urgent to clarify the physiological and pathological functions of the BNB. The present invention aims to provide a method for creating in vitro models that reproduce the anatomical structure of the BNB using cell sheet engineering technology with human-derived peripheral nerves. It has become possible to create an in vitro BNB model using all cell lines that make up the BNB (pericytes and endothelial cells), resulting in a 25% increase in barrier function compared to conventional methods. [Research Overview] - Successfully constructed an in vitro BNB model that maintains a two-layer structure, reproducing the original anatomical structure and physiological functions of the BNB. - Enabled the creation of an in vitro BNB model using all cell lines that make up the BNB, resulting in a 25% increase in barrier function compared to conventional methods. *For more details, please refer to the PDF document or feel free to contact us.
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【Purpose】 ■ Elucidation of the pathology and treatment of peripheral nerve diseases such as Guillain-Barré syndrome and diabetic neuropathy. *For more details, please refer to the PDF document or feel free to contact us.*
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Yamaguchi TLO Co., Ltd. is a TLO approved by the Ministry of Education, Culture, Sports, Science and Technology and the Ministry of Economy, Trade and Industry based on the Act on the Promotion of Technology Transfer from Universities, established in November 1999 with investments from 50 faculty members of Yamaguchi University (capital of 4 million yen) before incorporation. It is a liaison-type technology transfer organization that bridges people. We return the research results from the university to society in the form of technology transfer and other means. Additionally, we are actively recruiting member companies to prioritize the disclosure of invention information and contribute to the development of the local economy through these efforts.