Ultrasonic uniform cell treatment (disruption and dissolution) for 96 well plates

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basic information

The German company Hielscher is a manufacturer of ultrasonic processors for dynamic applications. They have successfully minimized energy loss due to internal heating to nearly zero, allowing their lab devices to operate without a cooling mechanism, achieving compact design and an ultrasonic conversion efficiency of over 98%. They offer a lineup of industrial devices with a maximum output of 16,000W per unit. Both lab and industrial models guarantee continuous operation for 24 hours. The purpose of cell and bacterial disruption is generally to extract specific components from within the cells or bacteria (such as proteins and nucleic acids). Various methods are commonly used for cell disruption, including bead milling, pressure disruption (French press), and freeze-thaw cycles, but ultrasonic disruption is also widely used. Ultrasonic cell disruption using a bath is a reliable method with good reproducibility; however, it has been challenging to uniformly treat multiple sample specimens simultaneously. The ultrasonic device UIP400MTP can uniformly process 96 samples in various shapes of 96-well plates, achieving excellent cell disruption and extraction yields.

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P5

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Applications/Examples of results

In cell-based analyses such as ELISA and PCR, it is necessary to extract target molecules from within cells through cell lysis and cell disruption as a preprocessing step. Examples of applications: 1. Detachment of adherent cells 2. Dissolution of protein precipitates The purpose of cell or bacterial disruption is generally to extract specific components within the cells or bacteria (such as proteins and nucleic acids). Common methods for cell disruption include bead milling, pressure disruption (French press), and freeze-thaw cycles, but ultrasonic disruption is also widely used. Ultrasonic cell disruption using a bath is a reliable method with good reproducibility; however, it has been challenging to uniformly treat multiple samples simultaneously. The ultrasonic device UIP400MTP can uniformly process 96 samples in various shapes of 96-well plates, achieving excellent cell disruption and extraction yields.