This is a substrate that easily aligns cultured cardiac muscle cells. It facilitates the fabrication of anisotropic cardiac muscle sheets.
By aligning cultured cardiomyocytes, a sheet can be constructed that reproduces anisotropic excitation propagation similar to cardiac tissue. Anisotropic cardiomyocyte sheets are electrically stable and have a low incidence of reentry. The incidence of reentry induced by drug action in anisotropic cardiomyocyte sheets shows a high correlation with clinical data. The quantification of "drug-induced arrhythmogenic effects," which was difficult with existing testing methods, becomes possible with anisotropic cardiomyocyte sheets. References: Biomaterials 34, 8878–8886 (2013) DOI: 10.1016/j.biomaterials.2013.07.039 Adv Mater. 2017 Jan;29(1) DOI: 10.1002/adma.201602448
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basic information
Material: Polystyrene (sterilized) Dimensions: 10mm x 10mm or 10mm diameter Structure: Grooves on the surface with a spacing of 5μm, width of 15μm, and depth of 5μm Quantity: 10 sheets, 20 sheets, 50 sheets, 100 sheets, others Usage: Please coat the substrate with a matrix such as Corning Matrigel basement membrane matrix before seeding cells. This product is disposable.
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This is a substrate for seeding cardiomyocytes to create anisotropic cardiomyocyte sheets. By visualizing reentry occurring on the anisotropic cardiomyocyte sheets through membrane potential optical measurements, it becomes possible to quantify the risk of drug-induced arrhythmogenic effects. References: Biomaterials 34, 8878–8886 (2013) DOI: 10.1016/j.biomaterials.2013.07.039 Adv Mater. 2017 Jan;29(1) DOI: 10.1002/adma.201602448
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Dimensions of the grooves on the substrate
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After developing a high-speed imaging device necessary for neuroscience research, Brain Vision was established in May 1998 as an official venture of RIKEN with the aim of commercializing various ideas that emerged during neuroscience research. To date, over 100 high-speed imaging devices have contributed to advanced research activities at major neuroscience and cardiac research institutions around the world. In recent years, it has also been highly regarded in the field of optoelectronics and has already contributed to research and development at related research institutions and liquid crystal manufacturers. Further contributions in various industrial fields are expected in the future. Brain Vision aims to provide innovative technologies born from neuroscience research to the market and contribute to the advancement of science and industry.