Lipid nanoparticle (LNP) production device "Nunchuck"

Creating perfect lipid nanoparticles (LNPs) requires technology. Testing flow rates and formulations one by one to find the appropriate size of LNPs is time-consuming and wastes valuable payload. Additionally, scaling up often requires new workflows, and there are always such challenges in new gene therapy research. Nunchuck is a groundbreaking platform that combines two critical steps necessary for producing LNPs of optimal size: Total Flow Rate (TFR) screening and LNP formulation exploration. It can screen eight types of TFRs in just 10 minutes, quickly finding the sweet spot and allowing immediate production of LNPs with capacities ranging from 0.5 to 200 mL. Moreover, the produced LNPs can be quickly evaluated for physical properties, such as payload measurement, using Stunner. This webinar will introduce how to conduct TFR screening suitable for the purpose of creating size-tunable, high-quality RNA-LNPs and how to scale up. We will also demonstrate how to evaluate the produced LNPs with Stunner.

Lipid nanoparticles (LNPs) are currently one of the most notable delivery systems used in mRNA vaccines, gene therapy, cancer treatment, and more. However, their development requires a complex process involving formulation screening, control of size and quality, removal of organic solvents, and characterization, which demands significant effort and time. In this webinar, we will introduce methods to enhance the production of perfectly sized LNPs, characterization of size and quality, buffer exchange and sample concentration, and stability analysis techniques at each step of the development process workflow.

CPhI Japan Exhibition & Mini Seminar! April 19 (Wed) - April 21 (Fri) @ Tokyo Big Sight Unchained Labs, Inc. will be exhibiting in the biopharmaceutical zone at CPhI Japan this year as well. This time, we will also hold a mini seminar at our booth with plenty of participation benefits! Please come visit our booth at Tokyo Big Sight. <Mini Seminar> - "Mastering the Research and Development of Lipid Nanoparticles (LNP) to Earn Your Black Belt" - "Let Automation Handle Buffer Exchange and Go Home on Time" *Please check the [Pre-registration Form] for the schedule. <Mini Seminar Participation Benefits> [Benefit 1] Pre-register to receive our original eco-bag that fits a PC! [Benefit 2] Attend on the day to gain a chance to win a 3000 yen QUO card! [Benefit 3] Get technical questions and consultations answered on the spot. <Pre-registration Form> Register now using the link below to get [Benefit 1]! *Separate web pre-registration or invitation is required for entry to the exhibition.

<Announcement of Interphex Exhibition and Product Technology Seminar> Our company will be exhibiting at the Interphex Pharma Lab EXPO again this year. Additionally, on the first day of the exhibition, July 5th, we will also be presenting at a product technology seminar! We invite you to come to Tokyo Big Sight. Exhibition Details: Name: Interphex Week Tokyo (25th Edition) Date: July 5 (Wednesday) - July 7 (Friday) 10:00-17:00 Venue: Tokyo Big Sight, East Hall 1, Booth: 1A-10 Details of our exhibited products: https://www.interphex.jp/tokyo/ja-jp/search/2023/directory/directory-details.org-fc5952a0-dbf6-4ef7-bfa0-2feb60a9169f.html Product Technology Seminar: "Innovative Next Steps in Pharmaceutical Development Using Lipid Nanoparticles" We will introduce a solution that allows for high-throughput processes from the examination of conditions for lipid nanoparticle production to buffer exchange and physical property evaluation. Date and Time: July 5 (Wednesday) 12:30-13:00 Venue: Room 4 (East Hall 5)