A large-scale culture device for stem cells boasting the world's highest processing capacity.
■Features - Automated culture system accepted under the second type of regenerative medicine provision plan (osteoarthritis of the knee) ■Cell Type Adherent cells ■Cell Processing Capacity For adipose-derived mesenchymal stem cells, it is possible to culture up to 6*10^9 cells (600 million cells) in about 40 days (after 2 passages) (iPS cells can be cultured in amounts 10 times greater) ■Simultaneous Culture of Multiple Samples Not supported (it is possible to culture the required number of cells for multiple uses at once) ■Culture Period The doubling time of the cells remains the same as in general culture methods, but the cell count will reach 10 times the initial amount in about 10 days. ■Cell Quality Since the culture method does not involve constant stirring, there is no fluid stress, and there are no changes in cell quality. Our research has confirmed the following: - Maintenance of stem cell markers and retention of differentiation potential - No enlargement of cell diameter or aging phenomena - No chromosomal changes that could lead to tumorigenesis, and no tumor formation after transplantation ■Cell Recovery Rate and Viability Over 90% ■Adjustment of Cultured Cell Numbers It is possible to adjust the number of cells by modifying the amount of non-woven fabric that serves as the cell scaffold.
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basic information
Automatic Process: Medium exchange, stirring, oxygenation, cell recovery (excluding cell seeding and purification) Temperature Control Range: Room temperature to 42°C ±0.5 in the equipment chamber CO2 Concentration Control Range: 0 to 8% Dimensions: W420 × H590 × D435 (mm) Weight: 45kg Power Supply: AC100-220V 50/60Hz
Price range
P7
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Applications/Examples of results
Medical institutions (Kanto, Kansai, Fukuoka), universities, pharmaceutical companies, etc. (Culture achievements) - Human mesenchymal stem cells (derived from adipose tissue, dental pulp, umbilical cord, bone marrow, etc.), iPS cells, fibroblasts - Animal cells (pig, horse, dog, etc.)
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Company information
In recent years, stem cell therapy as a form of regenerative medicine has become increasingly active, but in many of these settings, a few clinical culture specialists are burdened with complex tasks. For the future spread and generalization of regenerative medicine, it is believed that new culture methods specialized for stem cells, capable of securing a sufficient quantity of cells for treatment, are necessary. Our company has established a method for cultivating a large number of cells by utilizing non-woven fabric as a scaffold material. By using our developed high-density 3D large-scale culture device and recovery method, it is possible to cultivate and recover approximately 60 doses of therapeutic cells (6x10^9 cells) with simple operation by one person. We are continuously seeking partners who can engage in clinical research and treatment using our developed technology, as well as in the manufacturing of therapeutic cells and exosomes.
