It is possible to strongly retain solutes! Beneficial not only for LC/MS but also for preparative chromatography.
This document explains Hydrophilic Interaction Liquid Chromatography (HILIC), which is a suitable separation method for highly polar hydrophilic compounds. It includes the basic theory of HILIC and notes on precautions when using the separation mode. Additionally, it introduces the zwitterionic ZIC-HILIC series from Merck SeQuant and describes application examples for various hydrophilic compounds. We encourage you to read it. [Contents (excerpt)] ■ Introduction ■ For first-time users of ZIC-HILIC ■ Why HILIC mode? ■ Equipment ■ Principle of separation *For more details, please refer to the PDF document or feel free to contact us.
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【Other Published Content (Excerpt)】 ■ Column Care ■ Mobile Phase ■ Injector ■ Sample Preparation Precautions ■ Features of the ZIC-HILIC Series *For more details, please refer to the PDF document or feel free to contact us.
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【Analysis Examples】 ■ Analysis of nucleotides, analysis of purines and pyrimidines ■ Analysis of cAMP, AMP, ADP, ATP, and high-speed analysis of AMP and ATP, etc. *For more details, please refer to the PDF materials or feel free to contact us.
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From research and development of pharmaceuticals to manufacturing and diagnostics, Merck is working to solve various challenges in life sciences in collaboration with the global science community. Merck's products include over 300,000 items, ranging from laboratory pure and ultra-pure water systems to gene editing tools for drug manufacturing, antibodies, cell lines, and end-to-end systems. To realize promising research more quickly and safely, we closely collaborate with customers in academia, the biotechnology industry, and the pharmaceutical industry. Please feel free to contact us for inquiries about our products or if you are interested in raw material supply. Here is the Merck ultra-pure and pure water systems webpage → https://www.merckmillipore.com/LW Here is the Merck life science reagents, raw materials, and analysis webpage → https://www.sigmaaldrich.com/JP/ja