Administration of little amount of prepared liquid drug shows excellent antitumor efficacy!
Many cancers spread to regional lymph nodes through the lymphatic vessels. Intravenous administration of chemotherapeutic agents through blood vessels is a common treatment for metastatic lymph nodes. Drugs administered intravenously leak from the capillaries into the interstitium in peripheral tissues and are reabsorbed by the blood vessels and lymphatic vessels. However, the lymphatic system is characterized by the preferential uptake of large-sized particles and polymers, and thus anticancer drugs, which are generally small molecules, are considered difficult to deliver to the lymphatic system. A modern drug delivery system by lymphatic vessels can deliver drugs to a target lymph nodes directly. In this way, not only these lymph nodes, but also the downstream lymphatic system can be treated properly. This invention shows that a liquid preparation having a particular osmotic pressure range provided high drug retention in the target lymph node, high delivery to the downstream lymph node, and excellent drug efficacy. The investigation for diseases other than cancers is being researched with data unpublished.
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The revenue generated from technology transfer is reinvested as new research funding for universities and researchers, and is utilized to create further research outcomes. To ensure the smooth operation of this cycle, known as the "Intellectual Creation Cycle," we will vigorously promote technology transfer. The types of seeds we handle include patents, know-how, databases, and programs. We have established a collaborative framework by signing basic technology transfer agreements with the following universities (as of June 1, 2025): Tohoku University, Hirosaki University, Iwate University, Akita University, Fukushima University, Yamagata University, Tohoku Gakuin University, Iwate Medical University, Fukushima Medical University, Aizu University, Miyagi University, Hokkaido University, Muroran Institute of Technology, and Showa Medical University.
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