Tohoku Univ. Technology : Method for predicting lung function : T21-173
Convert 3DCT to SPECT ventilation imaging
Pulmonary function imaging has been reported to provide valuable information for radiation therapy, and methods have been implemented to minimize dose deposition in high-functioning lung regions. Currently, most lung ventilation and perfusion imaging methods are based on the use of radioisotopes or contrast agents, such as single-photon emission computed tomography (SPECT) and positron-emission tomography (PET). Although these imaging techniques provide much useful information for local lung function, they have disadvantages such as radiation exposure, high cost, and requirement of special equipment. The inventors aimed to obtain lung function images from only 3DCT images taken at each treatment session. In recent years, it has become common to use deep learning (DL) for some tasks in radiotherapy, especially convolutional neural networks (CNN) for image processing. In the past, there have been attempts to convert 4DCT images into SPECT images, but they have not been sufficiently successful. In this study, the inventors developed a DL-based method to directly convert 3DCT images into krypton -81M gas (81mKr-gas) SPECT V images for the first time in the world. The present invention shows the possibility of predicting lung function from CT images alone with high accuracy and is expected to contribute to radiotherapy.
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The revenue generated from technology transfer is reinvested as new research funding for universities and researchers, and is utilized to create further research outcomes. To ensure the smooth operation of this cycle, known as the "Intellectual Creation Cycle," we will vigorously promote technology transfer. The types of seeds we handle include patents, know-how, databases, and programs. We have established a collaborative framework by signing basic technology transfer agreements with the following universities (as of June 1, 2025): Tohoku University, Hirosaki University, Iwate University, Akita University, Fukushima University, Yamagata University, Tohoku Gakuin University, Iwate Medical University, Fukushima Medical University, Aizu University, Miyagi University, Hokkaido University, Muroran Institute of Technology, and Showa Medical University.
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