We manufacture and sell four types of trapping reagents that can be used for pharmacokinetic studies and toxicity studies.
These trapping reagents can be used for the detection and analysis of reactive metabolites that may arise during the metabolic processes of drug candidate compounds. ◆R00846 CysGlu-Dan Traditionally, Dansyl-GSH (dGSH) has been used in trapping tests for electrophilic reactive metabolites generated by CYP oxidation; however, Dansyl-GSH was unable to detect "hard" electrophilic reactive metabolites such as aldehydes. CysGlu-Dan, like Dansyl-GSH, can react with "soft" electrophilic reactive metabolites such as quinones and epoxides, as well as with "hard" electrophilic reactive metabolites, allowing for the sensitive detection of a broader range of reactive metabolites. ◆R00845 Dap-Dan This reagent can trap and detect reactive 1-O-acyl glucuronides generated during the glucuronidation process, as well as aldehydes produced through rearrangement. ◆R00847 Cys-Dan This reagent can trap and detect reactive acyl-CoA generated during the metabolic processes of fatty acids. These trapping reagents were developed by a group led by Professor Tomoyuki Oe at the Faculty of Pharmacy, Keio University.
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basic information
◇R00846 CysGlu-Dan 【Specification】Purity (HPLC) 98% or higher 【Storage Conditions】Frozen, light-protected, filled with inert gas ◇R00845 Dap-Dan 10mg 16,000 yen / 50mg 48,000 yen / 100mg 86,000 yen 【Specification】Purity (HPLC) 98% or higher 【Storage Conditions】Frozen, light-protected, filled with inert gas ◇R00847 Cys-Dan 10mg 30,000 yen / 50mg 120,000 yen / 100mg 200,000 yen 【Specification】Purity (HPLC) 98% or higher 【Storage Conditions】Frozen, light-protected, filled with inert gas ◇R02168 Dansyl-GSH 10mg 27,000 yen / 50mg 90,000 yen / 100mg 140,000 yen 【Specification】Purity (HPLC) 98% or higher 【Storage Conditions】Frozen, light-protected, filled with inert gas
Price information
R00846 CysGlu-Dan 10mg 45,000 yen / 50mg 180,000 yen / 100mg 320,000 yen R00845 Dap-Dan 10mg 16,000 yen / 50mg 48,000 yen / 100mg 86,000 yen R00847 Cys-Dan 10mg 30,000 yen / 50mg 120,000 yen / 100mg 200,000 yen R02168 Dansyl-GSH 10mg 27,000 yen / 50mg 90,000 yen / 100mg 140,000 yen
Price range
P2
Delivery Time
P3
Applications/Examples of results
◇R00846 CysGlu-Dan For trapping tests of reactive metabolites generated by CYP oxidation. (Both hard and soft are detectable!) ◇R00845 Dap-Dan For trapping tests of reactive acyl glucuronides. ◇R00847 Cys-Dan For trapping tests of reactive acyl CoA. ◇R02168 Dansyl-GSH For trapping tests of reactive metabolites generated by CYP oxidation.
Line up（4）
| Model number | overview |
|---|---|
| R00846 | CysGlu-Dan |
| R00845 | Dap-Dan |
| R00847 | Cys-Dan |
| R02168 | Dansyl-GSH |
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Company information
Since we started manufacturing and selling Boc-amino acids in 1982, we have gradually expanded our product offerings to include Z-amino acids, Fmoc-amino acids, and resins for solid-phase synthesis. Currently, we also sell special amino acids, non-natural amino acids, coupling agents, coupling additives, and solvents for peptide synthesis, providing a wide range of reagents related to peptide synthesis. We actively engage in contract synthesis of amino acid derivatives (both natural and non-natural) that are not listed in our catalog, as well as bulk supply of resins for solid-phase synthesis, short-chain peptides, and various compounds.