Self-disconnecting tags - high-purity refinement in one step.
Cytiva Protein Select resin allows for the spontaneous cleavage between the tag and the target protein during the affinity step, resulting in the elution of high-purity target protein without any residual amino acids from the tag. 【Self-Cleavage of the Tag】 The Cytiva Protein Select tag binds to the ligand on the resin, and after a certain period, the tag is cleaved from the target protein. This means that no enzymatic digestion is required! 【No Residual Amino Acids from the Tag】 Since the cleavage occurs between the tag and the target, no amino acids from the tag remain in the target protein. 【High Purity in One Step】 The cleaved target can be eluted from the column simply by flowing the starting buffer. There is no need for pH changes or the addition of reagents for elution.
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Cytiva and Pall Life Sciences have merged their businesses and will officially launch under the "Cytiva" brand on May 1, 2023. Under our mission of "Advancing therapies, faster," we will integrate both organizations and focus even more on supporting the development and manufacturing of better therapies for patients as a stronger global provider of technologies and services. The new Cytiva will offer a broader and deeper expertise and a rich lineup of products and services to better support various customers involved in research and the manufacturing and development of biopharmaceuticals, enabling them to deliver therapies to patients more quickly, from discovery to delivery. With a rich history spanning several hundred years, Pall Life Sciences and Cytiva, as part of the Danaher Group, will continue to unite to provide better services to our customers.