Ion exchange resins for initial and intermediate purification at process scale
Capto Q increases particle rigidity while maintaining pore size, which is essential for binding capacity at process scale. By coating agarose resin with dextran surface extender, it achieves a high dynamic binding capacity. ● Reduces process time with high binding capacity, high flow rate, and low delivery pressure ● Enables purification at high bed heights with rigid agarose resin ● Allows purification of viscous samples under high flow rate conditions Additionally, separation of AAV full/empty can be achieved through ion exchange chromatography. ● Purification of Full Capsids with a purity of 95-100% ● Improved selectivity with Capto Q's Dextran Extender ● Reduced selectivity with resin lacking Dextran Extender ● Improved selectivity for Full/Empty due to optimized buffer
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Cytiva and Pall Life Sciences have merged their businesses and will officially launch under the "Cytiva" brand on May 1, 2023. Under our mission of "Advancing therapies, faster," we will integrate both organizations and focus even more on supporting the development and manufacturing of better therapies for patients as a stronger global provider of technologies and services. The new Cytiva will offer a broader and deeper expertise and a rich lineup of products and services to better support various customers involved in research and the manufacturing and development of biopharmaceuticals, enabling them to deliver therapies to patients more quickly, from discovery to delivery. With a rich history spanning several hundred years, Pall Life Sciences and Cytiva, as part of the Danaher Group, will continue to unite to provide better services to our customers.
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