Contributing to a bioreactor for the proliferation of hematopoietic stem cells under microgravity.
BioServe Space Technologies is a center located within the Department of Aerospace Engineering at the University of Colorado Boulder in the United States. To date, it has been involved in over 90 space missions, conducting experiments in life sciences in microgravity environments, including the design and construction of hardware. Currently, BioServe Space Technologies is developing a system called the BioServe In-Space Cell Expansion Platform (BICEP) to support the proliferation of hematopoietic stem cells in microgravity. Hematopoietic stem cells are the precursor cells for red blood cells, white blood cells, and platelets. Bone marrow transplantation, a treatment method for leukemia and cancer, involves infusing hematopoietic stem cells harvested from healthy donors into patients, allowing them to settle in the patient's bone marrow and regenerate the blood system. Additionally, when proliferated on Earth, the proportion and robustness of stem cells decrease as the culture progresses. It is believed that the microgravity environment better mimics the conditions of hematopoietic stem cells within the bone marrow, and it is expected that it will enable the proliferation of higher quality cells for transplantation.
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**Challenges and Solutions** To perfuse approximately 2 mL/min of culture medium within the BICEP device, BioServe Space Technologies was looking for a compact and reliable peristaltic pump. The RP-Q series tube pump was chosen not only because it met the above conditions but also due to its proven track record in space. Additionally, our ability to customize the pump by extending the tubing to fit the device was also appreciated. In ground experiments, the pump has been operating stably. On August 3, 2024, this experimental device was launched from Florida, USA, aboard the resupply ship "Cygnus," and arrived safely at the ISS on the 6th. It is expected to contribute to the proliferation experiments of hematopoietic stem cells in microgravity.
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Our company has been a specialized manufacturer of over 10,000 types of solenoid valves, small pumps, and other fluid control devices for more than 60 years, providing technology related to automatic and precise control of liquids and gases. We excel in custom design tailored to the individual needs of our customers and are expanding globally. 【Customization】 As a specialist in fluid control, we flexibly respond to all product design requirements from our customers. Based on our extensive experience and fresh ideas, we actively propose various product customizations according to individual requests. We also accommodate small-scale prototypes, so please feel free to reach out. 【Miniaturization】 We are developing small and micro fluid control products, including the world's smallest class of small valves, the FV and FLV series. 【Integration】 If you provide us with your desired specifications and an overall flow diagram, we will consider the optimal selection and arrangement of components and propose integration products. <<Others>> - Established a seismic isolation factory compliant with BCP - Opened a branch in the United States in October 2012 as part of our global expansion.